DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment tutl and SDK2

DIOPT Version :9

Sequence 1:NP_001303307.1 Gene:tutl / 46015 FlyBaseID:FBgn0010473 Length:1536 Species:Drosophila melanogaster
Sequence 2:NP_001138424.1 Gene:SDK2 / 54549 HGNCID:19308 Length:2172 Species:Homo sapiens


Alignment Length:1610 Identity:338/1610 - (20%)
Similarity:538/1610 - (33%) Gaps:460/1610 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   212 LNLTNIRESDQGWYECKVVFLNRDPKQHKNGTWFHLDVHAPPRFSVTPEDIIYVNLGDSIILNCQ 276
            |.:.|...||.|:|||:.|..:........|.  :|.|..||:|...||..|...:...:.:.||
Human   269 LTIPNPTGSDAGYYECEAVLRSSSVPSVVRGA--YLSV
LEPPQFVKEPERHITAEMEKVVDIPCQ 331

  Fly   277 ADGTPTPEILWYKDANPVDPSPTVGI--FNDGTELRISTIRHEDIGEYTCIARNGEGQVSHTARV 339
            |.|.|.|.|.|||||..|:.......  .||| .|:||.:..:|.|.:.|.|||..|:|..:..:
Human   332 AKGVPPPSITWYKDAAVVEVEKLTRFRQRNDG-GLQISGLVPDDTGMFQCFARNAAGEVQTSTYL 395

  Fly   340 IIAGGAV-IMVPPTNQTKLEGEKVIFSCEAKAMPGNVTVRWYREGSPVREVAALE-TRVTIRKDG 402
            .:...|. |...|.:.|.::|..|:.:||....| ...:.| ::|..:....::: .|.|..:.|
Human   396 AV
TSIAPNITRGPLDSTVIDGMSVVLACETSGAP-RPAITW-QKGERILASGSVQLPRFTPLESG 458

  Fly   403 SLIINPIKPDDSGQYLCEVTNGIGDPQSASAYLSVEYPAKVTFTPTVQYLPFRLAGVVQCYIKSS 467
            ||:|:|....|:|.|.|..||..| ...|||.|.|....::|..|..|.:.......:.|.:...
Human   459 SLLISPTHISDAGTYTCLATNSRG-VDEASADLVV
WARTRITKPPQDQSVIKGTQASMVCGVTHD 522

  Fly   468 PQ--LQYVTWTKDKRLLEPYQMKDIVVMANGSLLFTRVNEEHQGQYACTPYNAQGTAGASGVMDV 530
            |:  ::|: |.||...|.......|.:..||||..::......|.|.|...:|.|....|.  .:
Human   523 PRVTIRYI-WEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSA--HL 584

  Fly   531 LVRKPPAFTVEP----ETLYQRKVGDSVEMHCDALEAEGTERPTIKWQRQEGEQLTESQRNR--- 588
            .||:.|.....|    .|:.:|.:..:.....|.      ..|.|::       :.|...|.   
Human   585 RVRQLPHAPEHPVATLSTVERRAINLTWTKPFDG------NSPLIRY-------ILEMSENNAPW 636

  Fly   589 ------IKISGGNITIENL-RREDFGYYQCVVSNEV--ATLMAVTQLVIEGTQPHA--PYNITGK 642
                  :.....::|::.| ....:.:..|.| |:|  ......|:.|....:|..  |.|:...
Human   637 TVLLASVDPKATSVTVKGLVPARSYQFRLCAV-NDVGKGQFSKDTERVSLPEEPPTAPPQNVIAS 700

  Fly   643 A-TESSITLQWLP---GYSGGSEYKQDYTIWFREAGVN-DWQTISVTPSGSTQVTINGLASGTTY 702
            . |..||.:||.|   .:..|  ..:.|.|.:..||:. .:|..::|.:....:.:..|...|.|
Human   701 GRTNQSIMIQWQPPPESHQNG--ILKGYIIRYCLAGLPVGYQFKNITDADVNNLLLEDLIIWTNY 763

  Fly   703 EFQVVGRNVLGDGMMSKVMTVRTLEDAPAA-PRNVKA-ATQ----------PPDSFFQLMPDEAD 755
            |.:|...|..|.|:.|..:|..||:..|.. |.||.| ||.          |...|...:.....
Human   764 EIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYK 828

  Fly   756 LLAY-------------------------------FDIYFHT----DSRGTLVYSPPKL-RVKGP 784
            |:|:                               |..||.:    .:.|....|.|:| |....
Human   829 LIAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHED 893

  Fly   785 KPGPPRNVSVTEVSNGFL-ITWQSPLERAHIVKFYTIKYRTDAQWKTLNRGQIR-----PEET-Q 842
            .|||..::|.:|:.:..| ::||.|.|:..|:..|.|      .|:..||...|     |..| :
Human   894 VPGPVGHLSFSEILDTSLKVSWQEPGEKNGILTGYRI------SWEEYNRTNTRVTHYLPNVTLE 952

  Fly   843 YLVKNLVGGRTYYFRVLANSEK--SYESSDEVKFPVP------------ARVKHKAIT------- 886
            |.|..|....||...|.|.:.|  ...|:..:...||            :.:..:::|       
Human   953 YRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGVPPELPGPPTNLGISNIGPRSVTLQFRPGY 1017

  Fly   887 --------------AGVVG-GILFFIVAIILSVCAVKICNKRKRRKQE-KEFNMVACRITDARNI 935
                          .|||| |..:.::.        ::.|:...|..| .:.|...|.....|.:
Human  1018 DGKTSISRWLVEAQVGVVGEGEEWLLIH--------QLSNEPDARSMEVPDLNPFTCYSFRMRQV 1074

  Fly   936 AANNHHLHNRSTGSISSGQVPLKKYKQTRISSLTAILIAILHWI-WPPDRCTNCHSIYSSPNLE- 998
            ........::.:..|.:.|.| .......:|..||...::  |: |.|           .|.:| 
Human  1075 NIVGTSPPSQPSRKIQTLQAP-PDMAPANVSLRTASETSL--WLRWMP-----------LPEMEY 1125

  Fly   999 DGDEDDGG--------GGRRRSVS-----RIQRSLD-------GRFVLDVEGVSKLG---YSQQT 1040
            :|:.:..|        .|..:::|     |::|...       ..:.:.|:..:.:|   :||..
Human  1126 NGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTV 1190

  Fly  1041 LESGNVDVVDGGLFERRNSNVSQKSSSD---------------DGGFLSRRNFITARASWRRP-- 1088
            :......|...|     .:|||..:::.               :|..|..:.....:.|..:|  
Human  1191 VGRTRESVPSSG-----PTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRF 1250

  Fly  1089 -LVASSSQLSLQSAADSARGFLQGL-------------LKIGAKQSAVPPNSQSYFDEA------ 1133
             ||..:|..|.|         |.||             .:||....:.||..:...|:.      
Human  1251 WLVEGNSSRSAQ---------LTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVPGPPMG 1306

  Fly  1134 -----VSGARYQNVLRPYTSSNNL---YGNADRSRPLHINTISGS-LSQQQQLYTPSRIS----- 1184
                 |.....:.:.:|..:.|.:   |....|......||.:.. |:...:.||.:.:.     
Human  1307 ILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVY 1371

  Fly  1185 --RIFS--------------------------SSP--QQLQPHHQQLLLS--SGGSGAYPTHFSD 1217
              ||.:                          |.|  ||.....:.:|||  .|..|..|..:..
Human  1372 LFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPGSDGLSPVRYYT 1436

  Fly  1218 LSTVYPPNS-----AERSSHNLSS----------RYRY------------YSQELPSLRTIQEET 1255
            :.|...|:.     :...|||.||          .|::            :|:|..||.|:|.  
Human  1437 IQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQA-- 1499

  Fly  1256 RRQQQQKQHPLEDHFVPLQLPSPPSWRSYYQSQASYRPRT------RWYPRHHSR----LFSNRQ 1310
                           .|.:.|          :..|..|.|      ||.|....:    |...|.
Human  1500 ---------------APDEAP----------TILSVTPHTTTSVLIRWQPPAEDKINGILLGFRI 1539

  Fly  1311 QQHEMLSPLPQLNLNLRNSMNPGGLEASPE--------SRSSSSGFGSKNTSNHPGSTSEWRLLP 1367
            :..|:|.. ......||...|||...|...        ||.|.:.:...|.:.|  ...|.| :.
Human  1540 RYRELLYE-GLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQYELDNLNKH--RRYEIR-MS 1600

  Fly  1368 PYRA----PPSPPKHSGYFGGQQAQGQTP-----HGSYSYPRATT---PP----------YTMAH 1410
            .|.|    |.|||:.  .|.|:......|     ||:.:.....|   ||          |.:..
Human  1601 VYNAVGEGPSSPPQE--VFVGEAVPTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYF 1663

  Fly  1411 W--------------------------------LEMISRLNAA------------TDSNLPKAPC 1431
            |                                :..::..|||            |....|.||.
Human  1664 WEAQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPS 1728

  Fly  1432 PVDV-------------------GSVDGH-YEFDPATPTPSASSMLREDL 1461
            .|..                   |.::|: ..::|.:|....|.::..|:
Human  1729 SVKFSELTTTSVNVSWEAPQFPNGILEGYRLVYEPCSPVDGVSKIVTVDV 1778

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tutlNP_001303307.1 V-set 137..250 CDD:284989 11/37 (30%)
IG_like 137..229 CDD:214653 8/16 (50%)
I-set 253..341 CDD:254352 32/89 (36%)
IGc2 268..331 CDD:197706 25/64 (39%)
I-set 346..437 CDD:254352 28/92 (30%)
Ig 349..437 CDD:299845 27/88 (31%)
Ig 459..530 CDD:299845 18/72 (25%)
IG_like 549..628 CDD:214653 12/90 (13%)
IGc2 551..617 CDD:197706 10/75 (13%)
FN3 633..725 CDD:238020 26/98 (27%)
FN3 786..874 CDD:238020 28/96 (29%)
SDK2NP_001138424.1 Ig 27..109 CDD:299845
IG_like 40..109 CDD:214653
I-set 120..203 CDD:254352
Ig 132..210 CDD:299845
IG_like 222..304 CDD:214653 11/36 (31%)
IGc2 233..286 CDD:197706 8/16 (50%)
I-set 308..397 CDD:254352 32/89 (36%)
Ig 326..394 CDD:143165 27/68 (40%)
I-set 402..492 CDD:254352 28/92 (30%)
Ig 416..492 CDD:299845 25/78 (32%)
Ig 502..586 CDD:299845 20/86 (23%)
IG_like 502..586 CDD:214653 20/86 (23%)
FN3 590..681 CDD:238020 15/104 (14%)
FN3 693..786 CDD:238020 25/94 (27%)
FN3 794..890 CDD:238020 17/95 (18%)
FN3 895..983 CDD:238020 28/93 (30%)
FN3 993..1087 CDD:238020 12/101 (12%)
FN3 1099..1194 CDD:238020 18/107 (17%)
FN3 1201..1290 CDD:238020 18/102 (18%)
FN3 1301..1394 CDD:238020 12/92 (13%)
FN3 1400..1484 CDD:238020 18/83 (22%)
FN3 1503..1616 CDD:238020 30/128 (23%)
FN3 1626..1719 CDD:238020 11/92 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1707..1729 4/21 (19%)
FN3 1724..1805 CDD:238020 10/55 (18%)
FN3 1837..1916 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2039..2067
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2098..2172
PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q6V4S5 2166..2172
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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