DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment tutl and Nrcam

DIOPT Version :9

Sequence 1:NP_001303307.1 Gene:tutl / 46015 FlyBaseID:FBgn0010473 Length:1536 Species:Drosophila melanogaster
Sequence 2:XP_017449758.1 Gene:Nrcam / 497815 RGDID:3209 Length:1315 Species:Rattus norvegicus


Alignment Length:1011 Identity:219/1011 - (21%)
Similarity:354/1011 - (35%) Gaps:293/1011 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 CRALST-----QHNTEKSKEQQQQSQPLEIPEQRAS------------KCRG------------- 47
            |:.:|.     .|. ||:|......||..|.:|...            :|..             
  Rat    24 CQMISALDVPLDHG-EKAKLLDDLVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRN 87

  Fly    48 ----DIDRTTTTTI-PASKTLT---ASPAKTAAFT-VKTTRRRRSRRRAEGSSICV-PIRRGQGS 102
                |||:....|: |.|.||.   .|..|...:. |.....|..|..|..::|.| |.|     
  Rat    88 GTHFDIDKDPLVTMKPGSGTLVINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSR----- 147

  Fly   103 TPTPTIQVLQFVLVSLLALLAKNAQAHNIPEDAVHITAILGEGVIFNCH--VEFPNDHPVPYVLQ 165
            :|..|.:.|:.:::.                        .|:.::..|.  :..|     |.::.
  Rat   148 SPLWTKERLEPIILR------------------------SGQSLVLPCRPPIGLP-----PAIIF 183

  Fly   166 W----------DKKVSETGSDLPIYIWYESYPEHIEEGY-----KGRVSRVSQDSPFGSASLNLT 215
            |          .::||: |.:..:| :....||...|.|     ......:.|..|.   ||.:.
  Rat   184 WMDNSFQRLPQSERVSQ-GLNGDLY-FSNVLPEDTREDYICYARFNHTQTIQQKQPI---SLKVI 243

  Fly   216 NIRE---------SDQGWYECKVVFLNRDPKQHKNGTWFHLDVHAPPRFSVTPEDIIYVN----- 266
            ::.|         ||..:|..|      ..|:.            ||.| :|||.    |     
  Rat   244 SVDELNDTIAANLSDTEFYGAK------SSKER------------PPTF-LTPEG----NESHKE 285

  Fly   267 --LGDSIILNCQADGTPTPEILWYKDANPVDPSPTVGIFNDGT-------------ELRISTIRH 316
              .|:.:.|.|.|:|.|||.|.|.|:              |||             .|:|..:..
  Rat   286 ELRGNVLSLECIAEGLPTPVIYWIKE--------------DGTLPVNRTFYRNFKKTLQIIHVSE 336

  Fly   317 EDIGEYTCIARNGEGQVSHTARVIIAGGAVIMVPPTNQTKLEGEKVIFSCEAKAMPGNVTVRWYR 381
            .|.|.|.|||:|..|.|.||..|.:......:|.|.|.....||.....|.|...| ...:.|..
  Rat   337 ADSGNYQCIAKNALGAVHHTISVTVKAAPYWIVAPHNLVLSPGENGTLICRANGNP-KPRISWLT 400

  Fly   382 EGSPVREVAALETRVTIRKDGSLIINPIKPDDSGQYLCEVTNGIGDPQSASAYLSV--EYPAKVT 444
            .|.|| |:|..:....|..| :::.:.::...|..|.|..:|..| ...|:|:::|  |.|..:|
  Rat   401 NGVPV-EIALDDPSRKIDGD-TIMFSNVQESSSAVYQCNASNKYG-YLLANAFVNVLAEPPRILT 462

  Fly   445 FTPTVQYLPFRLAGVVQCYIKSSPQ--LQYVTWTKDKRLLEPYQMKDIVVM-ANGSLLFTRVNEE 506
            ...|:..:......::.|....||.  :::...||...|.|     ||.|: .||:|......::
  Rat   463 SANTLYQVIANRPALLDCAFFGSPMPTIEWFKGTKGSALHE-----DIYVLHDNGTLEIPVAQKD 522

  Fly   507 HQGQYACTPYNAQGTAGASGVMDVLVRKPPAFTVEPE-TLYQRKVGDSVEMHCDALEAEGTERPT 570
            ..|.|.|...|..|.  |...:.:.::.|..|..:|| .:.||  |..|...| .::.:.|..||
  Rat   523 STGTYTCVARNKLGM--AKNEVHLEIKDPTRFIKQPEYAVVQR--GSKVSFEC-KVKHDHTLIPT 582

  Fly   571 IKWQRQEGEQLTESQRNRIKISGGNITIENLRREDFGYYQCVVSNEVATLMAVTQL-VIEGTQPH 634
            |.|.:..||...:   .|..:...::.:.:::.||.|.|.|..:..:.::.|...| |:..|...
  Rat   583 ILWLKDNGELPND---ERFSVDKDHLVVSDVKDEDGGTYTCAANTTLDSVSASAVLRVVAPTPTP 644

  Fly   635 AP-YNITG--------KATESSITLQWLPGYSGGS-------EYK---QDYTIWFREAGVNDWQT 680
            || |::..        ...:.|:.|.|.||....|       ||:   .:..:|..:|.|:..||
  Rat   645 APIYDVPNPPFDLELTNQLDKSVQLTWTPGDDNNSPITKFIIEYEDAMHEAGLWRHQAEVSGTQT 709

  Fly   681 ISVTPSGSTQVTINGLASGTTYEFQVVGRNVLGDGMMSKV------------MTVRTLEDAPAAP 733
                   :.|:.   |:....|.|:|:..|.:|..:.|:.            .....:|.....|
  Rat   710 -------TAQLK---LSPYVNYSFRVMAENSIGRSVPSEASEQYLTKAAEPDQNPTAVEGLGTEP 764

  Fly   734 RNVKAATQPPDSFFQLMP--------------DEADLLAYFDIYFHTDSRGTLVYSPPKLRVK-- 782
            .|:....:|.:.|....|              ||...:...::..:..| ||..:.|..::|:  
  Rat   765 DNLVITWKPLNGFQSNGPGLQYKVSWRQKDGDDEWTSVVVANVSKYIVS-GTPTFVPYLIKVQAL 828

  Fly   783 -----GPKPG-------------PPRNVSVTEVSNGFLITWQSPLERAHIVKFYTIKYRTDAQWK 829
                 .|:|.             .|.||.|:.|:        |.|..||              |.
  Rat   829 NDVGFAPEPAAVMGHSGEDLPMVAPGNVRVSVVN--------STLAEAH--------------WD 871

  Fly   830 TLNRGQIRPEETQYLVKNLVGGRTYYFRVLANSEKS 865
            .:....:|        .:|.|.|.||::..::|:::
  Rat   872 PVPPKSVR--------GHLQGYRIYYWKAQSSSKRN 899

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tutlNP_001303307.1 V-set 137..250 CDD:284989 23/138 (17%)
IG_like 137..229 CDD:214653 21/117 (18%)
I-set 253..341 CDD:254352 34/107 (32%)
IGc2 268..331 CDD:197706 23/75 (31%)
I-set 346..437 CDD:254352 23/90 (26%)
Ig 349..437 CDD:299845 23/87 (26%)
Ig 459..530 CDD:299845 19/73 (26%)
IG_like 549..628 CDD:214653 18/79 (23%)
IGc2 551..617 CDD:197706 16/65 (25%)
FN3 633..725 CDD:238020 24/122 (20%)
FN3 786..874 CDD:238020 18/93 (19%)
NrcamXP_017449758.1 IgI_NrCAM 50..144 CDD:409458 18/93 (19%)
Ig strand B 68..72 CDD:409458 0/3 (0%)
Ig strand C 81..85 CDD:409458 0/3 (0%)
Ig strand E 106..110 CDD:409458 2/3 (67%)
Ig strand F 124..129 CDD:409458 1/4 (25%)
Ig strand G 138..141 CDD:409458 0/2 (0%)
Ig 153..242 CDD:416386 18/122 (15%)
Ig strand A 153..156 CDD:409353 0/2 (0%)
Ig strand A' 158..162 CDD:409353 0/3 (0%)
Ig strand B 165..173 CDD:409353 1/7 (14%)
Ig strand C 180..186 CDD:409353 1/5 (20%)
Ig strand C' 189..192 CDD:409353 0/2 (0%)
Ig strand D 198..202 CDD:409353 2/4 (50%)
Ig strand E 204..208 CDD:409353 1/4 (25%)
Ig strand F 219..227 CDD:409353 1/7 (14%)
Ig strand G 230..242 CDD:409353 4/14 (29%)
Ig 281..362 CDD:416386 28/94 (30%)
Ig strand B 292..296 CDD:409353 1/3 (33%)
Ig strand C 305..309 CDD:409353 1/3 (33%)
Ig strand E 327..331 CDD:409353 1/3 (33%)
Ig strand F 341..346 CDD:409353 2/4 (50%)
Ig strand G 354..357 CDD:409353 1/2 (50%)
Ig 366..454 CDD:416386 23/91 (25%)
Ig strand B 382..386 CDD:409353 0/3 (0%)
Ig strand C 395..399 CDD:409353 0/3 (0%)
Ig strand E 419..423 CDD:409353 1/4 (25%)
Ig strand F 433..438 CDD:409353 2/4 (50%)
Ig strand G 446..449 CDD:409353 1/2 (50%)
Ig 460..546 CDD:416386 21/92 (23%)
Ig strand A 460..463 CDD:409353 0/2 (0%)
Ig strand A' 467..470 CDD:409353 0/2 (0%)
Ig strand B 476..483 CDD:409353 1/6 (17%)
Ig strand C 489..494 CDD:409353 0/4 (0%)
Ig strand C' 496..498 CDD:409353 1/1 (100%)
Ig strand D 505..509 CDD:409353 2/3 (67%)
Ig strand E 512..517 CDD:409353 2/4 (50%)
Ig strand F 525..533 CDD:409353 3/7 (43%)
Ig strand G 536..546 CDD:409353 2/11 (18%)
Ig 553..637 CDD:416386 22/89 (25%)
Ig strand A 553..556 CDD:409353 0/2 (0%)
Ig strand A' 558..562 CDD:409353 0/3 (0%)
Ig strand B 565..574 CDD:409353 2/9 (22%)
Ig strand C 582..587 CDD:409353 3/4 (75%)
Ig strand C' 590..593 CDD:409353 2/2 (100%)
Ig strand D 597..602 CDD:409353 1/4 (25%)
Ig strand E 603..609 CDD:409353 0/5 (0%)
Ig strand F 616..624 CDD:409353 3/7 (43%)
Ig strand G 627..637 CDD:409353 2/9 (22%)
FN3 651..741 CDD:238020 21/99 (21%)
fn3 754..836 CDD:394996 13/82 (16%)
fn3 852..944 CDD:394996 17/78 (22%)
fn3 957..1041 CDD:394996
fn3 1075..1143 CDD:394996
Bravo_FIGEY 1198..1287 CDD:404722
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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