DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tutl and NCAM2

DIOPT Version :9

Sequence 1:	NP_001303307.1	Gene:	tutl / 46015	FlyBaseID:	FBgn0010473	Length:	1536	Species:	Drosophila melanogaster
Sequence 2:	XP_011527877.1	Gene:	NCAM2 / 4685	HGNCID:	7657	Length:	874	Species:	Homo sapiens

Alignment Length:	903	Identity:	186/903 - (20%)
Similarity:	308/903 - (34%)	Gaps:	261/903 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 WYESYPEHI---------EEGYKGRVSRVSQDSPFGSASLNLTNIRESDQGWYECKVVFLNRDPK 237
            ||....|.|         :||.:.|              |.:.|....|.|.|.|:..    |.|
Human    78 WYNPQGEKIISTQRVVVQKEGVRSR--------------LTIYNANIEDAGIYRCQAT----DAK 124

  Fly   238 QHKNGTWFHLDVHAPPRFS--VTPEDIIYVNLGDSIILNCQADGTPTPEILWY---KDANPVDPS 297
            .........|:::....|.  |:|::.   ..|:...:.|:...:|.|.:.|.   ::...:..:
Human   125 GQTQEATVVLEIYQKLTFREVVSPQEF---KQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDN 186

  Fly   298 PTVGIFNDGTELRISTIRHEDIGEYTCIAR-NGEGQVSHTARVIIAGGAVIMVPPT--------N 353
            ....:.|:  .|:|..|...|.|.|.|..| ...|::.....::|     :.|||.        |
Human   187 RFAMLANN--NLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVI-----VNVPPAISMPQKSFN 244

  Fly   354 QTKLEGEKVIFSCEAKAMPGNVTVRWYREGSPVRE-----VAALETRVTIRKDGSLIINPIKPDD 413
            .|...||::.|||.|...| ...:.|:|.|..:.|     :....|.:|:|.    |||    .|
Human   245 ATAERGEEMTFSCRASGSP-EPAISWFRNGKLIEENEKYILKGSNTELTVRN----IIN----SD 300

  Fly   414 SGQYLCEVTNGIGDPQSASAYLSV-EYPAKVTFTPTVQYLPFRLAGVVQCYIKSSPQLQYVTWTK 477
            .|.|:|..||..|:.:. .|:|.| ..|..:.......|...::..|  |..:..| :..:||.:
Human   301 GGPYVCRATNKAGEDEK-QAFLQVFVQPHIIQLKNETTYENGQVTLV--CDAEGEP-IPEITWKR 361

  Fly   478 ----------DKRLLEPYQMKDIVVMANGSLLFTRVNEEHQGQYACTPYNAQGTAGASGVMDVLV 532
                      ||.|....::|.  ...:.||....|.....|:|.|...:..|....|..:|  :
Human   362 AVDGFTFTEGDKSLDGRIEVKG--QHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLD--I 422

  Fly   533 RKPPAFTVEPETLYQRKVGDSVEMHCDALEAEGTERPTIKWQRQEGEQLTESQRNRIKISGGN-- 595
            ...|.| :..:|:|....|:.:.:.||   .:.....:|.|:|.:.....::..|....|.|.
Human   423 EYAPKF-ISNQTIYYSWEGNPINISCD---VKSNPPASIHWRRDKLVLPAKNTTNLKTYSTGRKM 483

  Fly   596 -ITIENLRREDFGYYQCVVSNEVAT-----LMAVTQLVIEGTQPHAPYNITGKATESSITLQWL- 653
             :.|......|||.|.|..:|.:.|     ::|:..:      |.:||.:  |..|.|.|...:
Human   484 ILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADV------PSSPYGV--KIIELSQTTAKVS 540

  Fly   654 ---PGYSGGSEYKQDYTIWFREAGVNDWQTISVTPSGSTQVTINGLASGTTYEFQVVGRNVLGDG 715
               |...||... ..|.:..:|.....|:.:. :....|.|.:|.|...||||.:|...|..|.|
Human   541 FNKPDSHGGVPI-HHYQVDVKEVASEIWKIVR-SHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQG 603

  Fly   716 MMSKVMTVRTLEDAPAAPRNVKAATQPPDSFFQLMPDEADLLAYFDIYFHTDSRGTLVYSPPKLR 780
            ..||:                        ..||.:|....                   |||.:.
Human   604 DYSKI------------------------EIFQTLPVREP-------------------SPPSIH 625

  Fly   781 VKGPKPGPPRNVSVTEVSNGFLITWQSPLERAHIVKFYTIKYRTDAQWKTLNRGQIRPEETQYLV 845
            .: |..|....:|:|:..:|          .|.|:: |.:|||:            :.:|.|:|.
Human   626 GQ-PSSGKSFKLSITKQDDG----------GAPILE-YIVKYRS------------KDKEDQWLE 666

  Fly   846 KNLVGGRT------------YYFRVLANSEKSYESSDEVKFPVPAR---VKHKAITAGVVGGILF 895
            |.:.|.:.            |..::.|.:...|......:|.:|.:   :|........:|.::.
Human   667 KKVQGNKDHIILEHLQWTMGYEVQITAANRLGYSEPTVYEFSMPPKPNIIKDTLFNGLGLGAVIG 731

  Fly   896 FIVAIILSVCAV-------------------KICNKRK----RRKQEKEFN-----------MVA 926
            ..||.:|.:..|                   ::|.|:.    :.|:.:|..           :|.
Human   732 LGVAALLLILVVTDVSCFFIRQCGLLMCITRRMCGKKSGSSGKSKELEEGKAAYLKDGSKEPIVE 796

  Fly   927 CRITDARNIAANNH-------------------------HLHNRSTGSISSGQVPLKK 959
            .|..|.|   ..||                         ||       .|:|::|||:
Human   797 MRTEDER---VTNHEDGSPVNEPNETTPLTEPEYVAWSAHL-------CSNGKLPLKE 844

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tutl	NP_001303307.1	V-set	137..250	CDD:284989	16/76 (21%)
		IG_like	137..229	CDD:214653	13/55 (24%)
		I-set	253..341	CDD:254352	18/93 (19%)
		IGc2	268..331	CDD:197706	14/66 (21%)
		I-set	346..437	CDD:254352	31/103 (30%)
		Ig	349..437	CDD:299845	31/100 (31%)
		Ig	459..530	CDD:299845	17/80 (21%)
		IG_like	549..628	CDD:214653	18/86 (21%)
		IGc2	551..617	CDD:197706	16/68 (24%)
		FN3	633..725	CDD:238020	27/95 (28%)
		FN3	786..874	CDD:238020	18/99 (18%)
NCAM2	XP_011527877.1	Ig1_NCAM-2	46..137	CDD:143274	16/76 (21%)
		I-set	47..136	CDD:254352	16/75 (21%)
		I-set	142..218	CDD:254352	17/80 (21%)
		IGc2	153..214	CDD:197706	13/62 (21%)
		Ig	233..326	CDD:299845	31/102 (30%)
		I-set	240..323	CDD:254352	28/92 (30%)
		Ig5_NCAM-2	325..422	CDD:143278	20/103 (19%)
		IG_like	333..420	CDD:214653	18/91 (20%)
		IG_like	438..515	CDD:214653	17/79 (22%)
		IGc2	439..507	CDD:197706	16/70 (23%)
		FN3	521..613	CDD:238020	28/119 (24%)
		fn3	619..703	CDD:278470	22/126 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810