DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tutl and plum

DIOPT Version :9

Sequence 1:	NP_001303307.1	Gene:	tutl / 46015	FlyBaseID:	FBgn0010473	Length:	1536	Species:	Drosophila melanogaster
Sequence 2:	NP_001163744.1	Gene:	plum / 43197	FlyBaseID:	FBgn0039431	Length:	1298	Species:	Drosophila melanogaster

Alignment Length:	1322	Identity:	269/1322 - (20%)
Similarity:	429/1322 - (32%)	Gaps:	408/1322 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   238 QHKNGT----WFHLDVHAPPRFSVT-PEDIIYVNLGDSII-LNCQADGTPTPEILWYKDANPVDP 296
            |.||.|    :..:..||..|.::: |....|:.....:. .|...|..|. ...||::...|:.
  Fly    44 QPKNSTALQPYLQIQKHAVTRLTISKPHSPYYLPCIPILTPYNHDQDNQPI-YCSWYRNDVVVEQ 107

  Fly   297 ----SPTVGIFNDGTELRISTIRHEDIGEYTCIARNGEGQVSHTARVIIAGGAVIMVP------- 350
                .....|:::|| ||:.| ..:..|||.|       ::......:|:....:..|
  Fly   108 VSYRKNDFFIYDNGT-LRLPT-NEKASGEYYC-------KIEWDESAVISDRITVEYPVLKRLFP 163

  Fly   351 ----PTNQTKLEGEKVIFSCEAKAMPGNVTVRWY-REGSPVREVAALETRVTIRKDGSLIINPIK 410
                ..|.:.||.:.::.||...::|. ....|| ...|...:.:||     |..:|:||:..::
  Fly   164 GQQQAANISALENKPLVLSCPFLSVPA-ARFSWYFGNDSLTNDNSAL-----ILTNGTLILRHLR 222

  Fly   411 PDDSGQYLCEVTNGIG-------------DPQSASAYLSVEYPAKVTFTPTVQYLP-------FR 455
            .:.:|:|.|...|...             :|:.|:.|...|.....|.....|.||       |.
  Fly   223 LEQAGKYKCVAQNTFASKTHRQFIWQLQVEPKDATFYPKNEAGITETAVSEAQLLPAFQNATVFV 287

  Fly   456 LAG---VVQCYIKSS--PQLQYVTWTKDKRLLEPYQMKDIVVMANGSLLFTRVN---EEHQGQYA 512
            .||   ::||:..:.  |    :.|     .|:|...| :|.::|.|:.::..|   ..|:|:|:
  Fly   288 PAGGSVLLQCHAVADFVP----IVW-----YLQPPNNK-MVRLSNNSVAYSITNASIARHEGRYS 342

  Fly   513 C-TPYNAQGTAGASGVMDVLVRKPPAFT--VEPETLYQRKVGDSVEMHCDALEAEGTERPTIKWQ 574
            | ||...|.       ..|:|..||...  :..|.:|   :|.|..:.|   .|||...|:|.|.
  Fly   343 CITPLETQN-------FQVIVTTPPRIVSRLPVEVVY---IGLSRTLTC---RAEGHPEPSITWY 394

  Fly   575 RQEGEQLTESQRNRIKISGGNITIENLRREDFGYYQCVVSN----EVAT--------LMAVTQLV 627
             ..|..|..|...  .|||..:.:.:...::.|.||||..|    :.||        |..|..|.
  Fly   395 -HNGVHLNSSYTR--YISGNELHVHSFDSKEEGIYQCVARNVAGEDSATGELRFNRQLEEVNPLQ 456

  Fly   628 IEGTQPHAPYNITGKATESSITLQWLPGYSGGSEYKQDYTIWFREAGVNDWQTISVTPSGSTQVT 692
            .....||:.::|  ..|..|.||..:            :.::......:.|.:.|......|...
  Fly   457 NIRCYPHSFHSI--NITFDSRTLTSM------------FVVYIVRNNPHSWTSFSPMKLNQTSYV 507

  Fly   693 INGLASGTTYEFQVVGR------NVLGDGMMSKVMTVRTLEDAPAAPRNVKAATQ---------P 742
            :..........|.::.|      .|....::.:.|.:.:|...|     |...||         .
  Fly   508 VISTDLPVYEPFALITRVLFPTTEVRTGTLVPQQMILSSLRSTP-----VTCCTQGLMLRPIAVG 567

  Fly   743 PDSFFQLMPDEADLLAYFDIYF---HTDSRGTLVYSPPKLRVKGPKPGPPRNVSVTEVSNGFLIT 804
            .|:|.:....:.:...||.:.|   ||.                |.|        .::.||.|
  Fly   568 NDTFVKWSQGQLENKKYFILQFSINHTH----------------PHP--------AQLLNGSL-- 606

  Fly   805 WQSPLERAHIVKFYTIKYRTDAQWKTLNRGQIRPEETQYLVKNLVGGRTYYFRVLANSE------ 863
             |..|.        :::.:.|         |:|...|:....|.....|    ||.|.|
  Fly   607 -QGTLT--------SVEEKAD---------QVRHHLTEIQPLNQSAAAT----VLRNVEHEDNVV 649

  Fly   864 -KSYESSDEVKFPVPARVKHKAITAGVVGGILFFIVAIILSVCAV----------------KICN 911
             .:.|..|:: |.:       .:.|.|.|.:|.....|.:.|..:                ||..
  Fly   650 DDTLELEDDI-FSL-------VVDASVTGILLQRFTRIKMRVLIITTENEFLGQDFRYVQWKIIE 706

  Fly   912 KRKRRKQEKEFNMV-------ACRITDARN-IAANNHHLHNRSTGSISSGQVPLKKYKQTRISSL 968
            .....:....|.:|       |.:..|:.| ......|...::..|:.| |.|  |.:...|::.
  Fly   707 NGTSEQSNMPFRLVTRESRALAFKFLDSLNETCVLECHTEIQAQMSLPS-QDP--KCQDRNIANS 768

  Fly   969 TAILIAILHWIWPPDRCTNCHSIYSSPNLEDGD-----EDDGGGGRRRSVSRIQRSL-------- 1020
            ..::..:     .||...|.|.......:..||     |.|..|....|....|..|
  Fly   769 LLLVTGL-----KPDTRYNLHFYNCKTRIFYGDIDEKTEQDPPGTISNSKLIKQNGLKLMWEPPI 828

  Fly  1021 ---------DGRFVLD-------VEGVSKLGYSQQTLESGNVDVVDGGLFERRNSNVSQKSSSDD 1069
                     |.|:.||       |:..:|..|     :..||.       |....:|:.:...|.
  Fly   829 NPNGRVHHYDIRWSLDNVTHEAIVKECTKCSY-----KFPNVS-------ETAKIHVAVRVMGDT 881

  Fly  1070 G-GFLSRRNFITARASWRRPLVASS-----SQLSLQSAADSARGFLQGLLKIGAKQSAVPPNSQS 1128
            | |.....:.|....:|.:....||     |.:::.|....|..||.||..|
  Fly   882 GAGAPMYFDMINNNHTWLKEESESSHSEVYSGIAIGSLLSIACVFLFGLFII------------- 933

  Fly  1129 YFDEAVSGARYQNVLRPYTSSNNLYGN--------ADRSRPLHINTISGSLSQQQQLYTPSRISR 1185
             |.:....||.|......|.::..:||        .|.:..|...|:.....:.|.|...||..
  Fly   934 -FQQRNFKARAQGPTHLTTPTDINFGNLSSASGMPGDSAGGLSGGTLQQDCHEMQTLIPRSRYH- 996

  Fly  1186 IFSSSPQQLQPHHQQLLLSSGGSGAYPTHFSDLSTVYPPNS------AERSS------------- 1231
                  .:|.|.|         |..|.|..:.::.|:..|.      |.||.
  Fly   997 ------IELLPEH---------SLEYQTSTAAVAVVHLANGNGSVQVARRSDQDGAAQGDLGIAG 1046

  Fly  1232 -HNLSSRYRYYSQEL---------PSLRTIQEETRRQQQQKQHPLEDHFVPLQLPSPPSWRSYYQ 1286
             ||||        :|         |..:|:|:                 ..||           :
  Fly  1047 VHNLS--------QLPLCGVGGTSPERKTVQD-----------------AMLQ-----------E 1075

  Fly  1287 SQASYRPRTRWYPRHHSRLFSNRQ------QQHEMLSP---------LPQLNLNLRNSMNPGGLE 1336
            ::|.|.| .|..|.:...|.|::|      .:.|::.|         :|.|.:........||:.
  Fly  1076 AKAFYIP-YRHTPPNAVALSSSKQCAVPSGSELEVIVPPNSLPLVTTMPGLGVVGGGGSGGGGVG 1139

  Fly  1337 ASPE---SRSSSSGFGSKNTSN 1355
            .|..   |.||||...|.|.|:
  Fly  1140 GSSRRSGSLSSSSASSSSNGSS 1161

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tutl	NP_001303307.1	V-set	137..250	CDD:284989	4/15 (27%)
		IG_like	137..229	CDD:214653
		I-set	253..341	CDD:254352	19/93 (20%)
		IGc2	268..331	CDD:197706	16/67 (24%)
		I-set	346..437	CDD:254352	23/115 (20%)
		Ig	349..437	CDD:299845	23/112 (21%)
		Ig	459..530	CDD:299845	18/76 (24%)
		IG_like	549..628	CDD:214653	26/90 (29%)
		IGc2	551..617	CDD:197706	21/69 (30%)
		FN3	633..725	CDD:238020	14/97 (14%)
		FN3	786..874	CDD:238020	18/94 (19%)
plum	NP_001163744.1	IG_like	170..241	CDD:214653	19/76 (25%)
		IGc2	175..235	CDD:197706	16/65 (25%)
		IG_like	284..356	CDD:214653	22/88 (25%)
		I-set	360..443	CDD:254352	26/91 (29%)
		IGc2	378..435	CDD:197706	19/62 (31%)
		FN3	804..886	CDD:238020	19/93 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452276
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840