DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tutl and Cont

DIOPT Version :9

Sequence 1:	NP_001303307.1	Gene:	tutl / 46015	FlyBaseID:	FBgn0010473	Length:	1536	Species:	Drosophila melanogaster
Sequence 2:	NP_649461.2	Gene:	Cont / 40553	FlyBaseID:	FBgn0037240	Length:	1390	Species:	Drosophila melanogaster

Alignment Length:	982	Identity:	221/982 - (22%)
Similarity:	360/982 - (36%)	Gaps:	248/982 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   164 LQWDKKVSETGSDLP------IYIWYESY-PEHIEEGYKGRVSRVSQDSPFGSASLNLTNIRESD 221
            :.|.|.:.   .|.|      .|.|...| |..:||..:..|||        ..:|..:.|...|
  Fly   481 MNWGKSIF---CDPPQHYPDVRYYWARDYFPNFVEEDQRVFVSR--------DGALYFSFIETVD 534

  Fly   222 QGWYECKVVFLNRDPKQHKNGTWFHLDVHAPPRFSVTP----EDIIYVN-----------LGDSI 271
            :..|.|.|..|..|  ..:||.:|.|        .|||    :.:|:.|           .||.|
  Fly   535 RANYSCTVQTLVSD--TGRNGPFFPL--------RVTPNSNYQALIFANTFPKVFPEAPVAGDEI 589

  Fly   272 ILNCQADGTPTPEILWYKDANPVDPSPTVGIFNDGTELRISTIRHEDIGEYTCIARNGEGQVSHT 336
            .|.|.|.|.|.|...|.:...|:..:...  .|.|..|.|......|.|||:|...|....:..:
  Fly   590 RLECMAFGYPIPSYNWTRQGLPLQRNAYT--INYGRVLIIQNATTNDNGEYSCTITNPRKTLMKS 652

  Fly   337 ARVIIAGGAVIMVPPTNQTKLEGEKVIFSCEAKAMP-GNVTVRWYREGSPVREVAALETRVTIRK 400
            ..:.|.......:|..:..|.....|.|.|||.|:| .|.|  ||:....: :.|.:.....|.:
  Fly   653 IYINIQMRPQFTIPLKDMIKDYNSDVTFICEAFAIPDANYT--WYKNAERL-DPANINRDRYIIQ 714

  Fly   401 DGSLIINPIKPD-DSGQYLCEVTNGIGDPQSASAYLSVEYPAKVTFTPTVQ--------YLPFRL 456
            |..|.|..::.| |...|.|...|.: ....:||.|.|     ::..|:.:        |..:..
  Fly   715 DNVLTIKFLEKDKDDAMYQCGAQNQL-KTSFSSAQLRV-----LSMKPSFKKHPLESEVYAVYNG 773

  Fly   457 AGVVQCYIKSSPQLQYVTWTKDKRLLEPYQMKDIVVMANGSLLFTRVNEEHQGQYACTPYNAQGT 521
            ...:.|..:::|:.:: .|.||.:::.....:.|  :.:|:|..:..:.:.:|.|.|...|..||
  Fly   774 NTTIVCDPEAAPRPKF-QWKKDGQVIGSGGHRRI--LPSGTLTISPTSRDDEGIYTCIASNQAGT 835

  Fly   522 AGASGVMDVL-----VRKPPAFTVEPETLYQRKVGDSVEMHCDALEAEGTERPTIKWQRQEGEQL 581
            ..:...:.||     :..||...|..|       .|.:.:||:|...|..:...: | :..||.|
  Fly   836 DESHARVIVLQEIRFIETPPQRIVSKE-------HDLIFLHCEAAFDELLDIAYV-W-KHNGEVL 891

  Fly   582 TESQ--RNRIKISGGNITIENLRREDFGYYQCVVSNEVATLMAVTQLVIEGTQPHAPYNI-TGKA 643
            ..:.  ..||.:....:|:.|....|.|.|:|||.:.|..:.:.|.:.|||. |.||..: ..:.
  Fly   892 KNNHDGTGRIIVDWNRLTVHNTSMRDAGDYECVVKSAVNEISSKTSVSIEGA-PGAPGGVQVIQI 955

  Fly   644 TESSITLQWLPGYSGGSEYKQDYTIWFREAGVNDWQTISV--------TPSGSTQVTINGLASGT 700
            :::...::|:.|...|...:. |.|..|......|..:|.        ..:...|..:..|...:
  Fly   956 SKTKAIIEWVDGSHNGRAIRY-YNILGRTNWNRTWVNVSTHVQAREVDRYTSRQQAEVVNLTPWS 1019

  Fly   701 TYEFQVVGRNVLGDGMMSKVMTV-RTLEDAP-AAPRNVKAA---------TQPPDSFFQLMPDEA 754
            .|||.|...|.||.|..|....: .|.||.| .|||||...         |..|     |:|.|.
  Fly  1020 AYEFSVTAVNDLGIGTPSAPSPIYSTYEDKPYIAPRNVGGGGGKIGDLTITWDP-----LLPQEQ 1079

  Fly   755 DLLA-YFDIYF--------------HTDSRGTLV--------YSPPKLRV-------KGPKP--- 786
            .... ::.:::              ..|..|..|        |:..:::|       |||:.
  Fly  1080 HSHGIHYKVFWKLKGAIEWASDEIKKQDHMGVAVVNIPLNNYYTEYEVKVQAINSVGKGPESEIA 1144

  Fly   787 -----------GPPRNVSVTEVSNGFLITWQSPLE------RAHIVKFYTIKYRTDAQWKTLNRG 834
                       .|.:.:::...|..|.:||| |::      |..::. :.:||     |||.::.
  Fly  1145 VIHSAEDMPQVAPQKPIALAYNSTCFNVTWQ-PIDMSRENIRGKLIG-HRLKY-----WKTTHQE 1202

  Fly   835 QIRPEETQYLVKN------LVGGR--TYYF-RVLANS------------EKSYESSDEVKFPVPA 878
            :   :...||.:.      :||.:  |||| :|:|.:            |::|..:.:   ..|:
  Fly  1203 E---DSVYYLSRTTRNWALIVGLQPDTYYFVKVMAYNAAGEGPESERFEERTYRKAPQ---KPPS 1261

  Fly   879 RVKHKAITAGVVGGILFFIVAIILSVCAVKICNKRKRRKQEKEFNMVACRI--TDARNIAANNHH 941
            .|....|....|..:..::                ...:.|:.......||  :|...|.|||
  Fly  1262 SVHVYGINPSTVRVVWRYV----------------SPSQDEEPVEGYKVRIWESDQNMITANN-- 1308

  Fly   942 LHNRSTGSISSGQVPLKKYKQTRISSLTAILIAILHWIWPPDRCTNCHSI-YSSPNLEDGDEDDG 1005
                   :|    ||:.:..::.|::||            |.:..|...: ||          :|
  Fly  1309 -------TI----VPIGQKLESYINNLT------------PGKSYNMRVLAYS----------NG 1340

  Fly  1006 GGGRRRS 1012
            |.||..|
  Fly  1341 GDGRMSS 1347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tutl	NP_001303307.1	V-set	137..250	CDD:284989	25/92 (27%)
		IG_like	137..229	CDD:214653	18/71 (25%)
		I-set	253..341	CDD:254352	26/102 (25%)
		IGc2	268..331	CDD:197706	21/62 (34%)
		I-set	346..437	CDD:254352	26/92 (28%)
		Ig	349..437	CDD:299845	26/89 (29%)
		Ig	459..530	CDD:299845	14/70 (20%)
		IG_like	549..628	CDD:214653	21/80 (26%)
		IGc2	551..617	CDD:197706	19/67 (28%)
		FN3	633..725	CDD:238020	22/101 (22%)
		FN3	786..874	CDD:238020	25/128 (20%)
Cont	NP_649461.2	CLECT	139..>223	CDD:214480
		Ig	361..460	CDD:299845
		I-set	362..462	CDD:254352
		Ig	466..559	CDD:299845	25/98 (26%)
		IG_like	584..657	CDD:214653	21/74 (28%)
		IGc2	586..645	CDD:197706	20/60 (33%)
		Ig	667..751	CDD:299845	25/87 (29%)
		IG_like	676..751	CDD:214653	24/78 (31%)
		IG_like	765..844	CDD:214653	15/81 (19%)
		Ig	773..844	CDD:299845	14/73 (19%)
		I-set	851..940	CDD:254352	25/97 (26%)
		Ig	866..944	CDD:299845	23/80 (29%)
		FN3	944..1043	CDD:238020	22/99 (22%)
		FN3	1053..1146	CDD:238020	18/97 (19%)
		fn3	1156..1244	CDD:278470	23/97 (24%)
		fn3	1259..1346	CDD:278470	26/137 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452257
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10075
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940