DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tutl and LSAMP

DIOPT Version :9

Sequence 1:	NP_001303307.1	Gene:	tutl / 46015	FlyBaseID:	FBgn0010473	Length:	1536	Species:	Drosophila melanogaster
Sequence 2:	NP_001305844.1	Gene:	LSAMP / 4045	HGNCID:	6705	Length:	361	Species:	Homo sapiens

Alignment Length:	386	Identity:	98/386 - (25%)
Similarity:	146/386 - (37%)	Gaps:	69/386 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 IRRGQGSTPTPTIQVLQFVLVSLLALLAKNAQAHNIP--EDAVHITAILGEGVIFNCHVEFPNDH 158
            :||.|     |..:.|..||:.||.||.......::.  ....:||...|:..|..|.||..|..
Human     2 VRRVQ-----PDRKQLPLVLLRLLCLLPTGLPVRSVDFNRGTDNITVRQGDTAILRCVVEDKNSK 61

  Fly   159 PVPYVLQWDKKVSETGSDLPIYIWYESYPEHIEEGYKGRVSRVSQDSPFGSASLNLTNIRESDQG 223
                 :.|   ::.:|.         .:..|.:.....||....:.|.  ..||.:..:...|:|
Human    62 -----VAW---LNRSGI---------IFAGHDKWSLDPRVELEKRHSL--EYSLRIQKVDVYDEG 107

  Fly   224 WYECKVVFLNRDPKQHKNGT-WFHLDVHAPPRFSVTPEDIIYVNLGDSIILNCQADGTPTPEILW 287
            .|.|.|      ..||:..| ..:|.|..||:.|....|:. ||.|.::.|.|.|:|.|.|.|.|
Human   108 SYTCSV------QTQHEPKTSQVYLIVQVPPKISNISSDVT-VNEGSNVTLVCMANGRPEPVITW 165

  Fly   288 YKDANPVDPSPTVGIFNDGTE--LRISTIRHEDIGEYTCIARNGEGQVSHTARVIIAGGAVIMVP 350
            .      ..:||...| :|.|  |.|..|..|..|:|.|.|.| |...:...:|.:    .:..|
Human   166 R------HLTPTGREF-EGEEEYLEILGITREQSGKYECKAAN-EVSSADVKQVKV----TVNYP 218

  Fly   351 PT-----NQTKLEGEKVIFSCEAKAMPGNVTVRWYREGSPVREVAALETRVTIRKDGSLIINPIK 410
            ||     :.....|.:....|||.|:|. ....|||:.:.:.....||.:.| ....||.:..:.
Human   219 PTITESKSNEATTGRQASLKCEASAVPA-PDFEWYRDDTRINSANGLEIKST-EGQSSLTVTNVT 281

  Fly   411 PDDSGQYLCEVTNGIGDPQSASAYLSVEYPAKVTF---TPTVQYLPFRLAGVVQCYIKSSP 468
            .:..|.|.|...|.:|          |...:.|.|   .||:.: |.:..|....:.:..|
Human   282 EEHYGNYTCVAANKLG----------VTNASLVLFKRVLPTIPH-PIQEIGTTVHFKQKGP 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tutl	NP_001303307.1	V-set	137..250	CDD:284989	25/113 (22%)
		IG_like	137..229	CDD:214653	20/91 (22%)
		I-set	253..341	CDD:254352	30/89 (34%)
		IGc2	268..331	CDD:197706	23/64 (36%)
		I-set	346..437	CDD:254352	22/95 (23%)
		Ig	349..437	CDD:299845	22/92 (24%)
		Ig	459..530	CDD:299845	1/10 (10%)
		IG_like	549..628	CDD:214653
		IGc2	551..617	CDD:197706
		FN3	633..725	CDD:238020
		FN3	786..874	CDD:238020
LSAMP	NP_001305844.1	Ig	38..128	CDD:386229	25/114 (22%)
		Ig	132..215	CDD:386229	30/95 (32%)
		Ig_3	219..294	CDD:372822	19/76 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900