DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tutl and Dscam1

DIOPT Version :9

Sequence 1:	NP_001303307.1	Gene:	tutl / 46015	FlyBaseID:	FBgn0010473	Length:	1536	Species:	Drosophila melanogaster
Sequence 2:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster

Alignment Length:	1661	Identity:	332/1661 - (19%)
Similarity:	546/1661 - (32%)	Gaps:	536/1661 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 GEGVIFNCHVEFPNDHPVPYVLQWD---KKVSETGSDLPIYIWYESYPEHIEEGYK-GRVSRVSQ 203
            |..|...|   ....:|.|.: .|:   ||::.                  .:.|: |:...|:.
  Fly   447 GPSVFLKC---VAGGNPTPEI-SWELDGKKIAN------------------NDRYQVGQYVTVNG 489

  Fly   204 DSPFGSASLNLTNIRESDQGWYEC----KVVFLNRDPKQHKNGTWFHLDVHAPPRFSVTPEDIIY 264
            |.   .:.||:|::..:|.|.|:|    ||.......|         |:|:..|......:..|.
  Fly   490 DV---VSYLNITSVHANDGGLYKCIAKSKVGVAEHSAK---------LNVYGLPYIRQMEKKAIV 542

  Fly   265 VNLGDSIILNCQADGTPTPEILWYKDANPVDPSPTVGIFNDGTELRISTIRHEDIGEYTCIARNG 329
            .  |:::|:.|...|.|...|:|.:|...:..:....:|.:||.:..:..|:.|...|||:|:|.
  Fly   543 A--GETLIVTCPVAGYPIDSIVWERDNRALPINRKQKVFPNGTLIIENVERNSDQATYTCVAKNQ 605

  Fly   330 EGQVSHTARVIIAGGAVIM---VPPTNQTKLE-GEKVIFSCEAKAMPGNVTVRWYREGS------ 384
            ||   ::||..:....:::   ||...:..:. |:.:...|:.:.....:.|.|..|.|
  Fly   606 EG---YSARGSLEVQVMVLPQIVPFAYEDLINMGDSIDLFCQIQKGDRPIKVHWSFERSAGDYGF 667

  Fly   385 ----PVREVAALETRVTIRKDGSLIINPIKPDDSGQYLCEVTNGIGDPQSASAYLSVEYPAKVTF 445
                |     .:.|.....|...:.|....|..:|:..|..:|..| ..:.|..|:|..|.:...
  Fly   668 DQVQP-----QMRTNRISEKTSMISIPSASPAHTGRDTCIASNKAG-TTTYSVDLTVNVPPRWIL 726

  Fly   446 TPTVQYLPFRLAGVVQCYIKSSPQLQYVTWTK---DKRLLEPYQMKDI-----VVMANGSLLFTR 502
            .||.:.........|:|.....|:.| |||.|   |    .|.:.||:     :.:..|:|....
  Fly   727 EPTDKAFAQGSDAKVECKADGFPKPQ-VTWKKAVGD----TPGEYKDLKKSDNIRVEEGTLHVDN 786

  Fly   503 VNEEHQGQYACTPYNAQGTAGASGVMDVLVRKPPAFTVEPETLYQRKVGDSVEMHCDALEAEGTE 567
            :.:.::|.|.|...|..| :|.|.|:.:.|:.||.||.:......|: |:...:.|   ||:|.:
  Fly   787 IQKTNEGYYLCEAINGIG-SGLSAVIMISVQAPPEFTEKLRNQTARR-GEPAVLQC---EAKGEK 846

  Fly   568 RPTIKWQRQEGEQLTESQRNRIKI-----SGG---NITIENLRREDFGYYQCVVSNEVATLMAVT 624
            ...|.| .....:|.....||..|     |.|   :::|:...|.|...:.||.:|...:..|..
  Fly   847 PIGILW-NMNNMRLDPKNDNRYTIREEILSTGVMSSLSIKRTERSDSALFTCVATNAFGSDDASI 910

  Fly   625 QLVIEGTQPHAPYNI-----TGKATESSITLQWLPGYSGGSEYKQDYTIWFREAGVNDWQTIS-- 682
            .::::.. |..||.:     :|:    |:.|.|...|.|.|...: |.|.|:.:..: |..|.
  Fly   911 NMIVQEV-PEMPYALKVLDKSGR----SVQLSWAQPYDGNSPLDR-YIIEFKRSRAS-WSEIDRV 968

  Fly   683 VTPSGSTQVTINGLASGTTYEFQVVGRNVLGDGMMSKVMTVRTLEDAPAA-PRNVKAA------- 739
            :.|..:|:..:..|:..|||..::|..|.:|....|:.:|:.|.|:||:. |:|:|..
  Fly   969 IVPGHTTEAQVQKLSPATTYNIRIVAENAIGTSQSSEAVTIITAEEAPSGKPQNIKVEPVNQTTM 1033

  Fly   740 ----TQPPDSFFQLMPDEADLLAYFDIYFHTDSRGTLVYSP---------------PKLRV---- 781
                ..||.:.:     ..::|.|:..|..:::..:.|:..               ..|||
  Fly  1034 RVTWKPPPRTEW-----NGEILGYYVGYKLSNTNSSYVFETINFITEEGKEHNLELQNLRVYTQY 1093

  Fly   782 ------------------------KGPKPGPPRNVSVTEV-SNGFLITWQS-PLERAH-IVKFYT 819
                                    :|....||.:.:.|.: |....:.|.| |||.|: ::|.|.
  Fly  1094 SVVIQAFNKIGAGPLSEEEKQFTAEGTPSQPPSDTACTTLTSQTIRVGWVSPPLESANGVIKTYK 1158

  Fly   820 IKYRTDAQWKTLNRGQIRPEETQYLVKNLVGGRTYYFRVLANSEKSYESSDEVKFPVPARVKHK- 883
            :.|....:|.         :||:         |.|         |...|||.|...:.....:.
  Fly  1159 VVYAPSDEWY---------DETK---------RHY---------KKTASSDTVLHGLKKYTNYTM 1196

  Fly   884 ---AITAGVVGGILFFIVAIILSVCAVKICNKRKRRKQEKEFNMVACRITDARNIAANNHHLHNR 945
               |.|||..|            |.:|.|..:.:....|..        ||.:.:...|
  Fly  1197 QVLATTAGGDG------------VRSVPIHCQTEPDVPEAP--------TDVKALVMGN------ 1235

  Fly   946 STGSISSGQVPLKKYKQTRISSLTAILIAILHWIWP--PDRCTNCHSIYSSPNLEDGDEDDGGGG 1008
                                   .|||::   |..|  |:.....:::||.   .:|.|.:   .
  Fly  1236 -----------------------AAILVS---WRPPAQPNGIITQYTVYSK---AEGAETE---T 1268

  Fly  1009 RRRSVSRIQRSLDGR-------FVLDVEGVSKLGYSQQTLESGNVDVVDGGLFERRNSNVSQKSS 1066
            :.:.|...|.|.:..       :...|...:.:|..||:          ..:....:..|..|.:
  Fly  1269 KTQKVPHYQMSFEATELEKNKPYEFWVTASTTIGEGQQS----------KSIVAMPSDQVPAKIA 1323

  Fly  1067 SDDGGFLSRRNFITARASWRRPLVASSS---QLSLQ------SAADSARGFLQG--LLKIGAKQS 1120
            |.|..|.:     |.:...:.|.:|..:   :::.:      ||.|..|....|  |:|...:|.
  Fly  1324 SFDDTFTA-----TFKEDAKMPCLAVGAPQPEITWKIKGVEFSANDRMRVLPDGSLLIKSVNRQD 1383

  Fly  1121 A-----------------------VPPNSQSYFDEAVSGARYQNVLRPYTSSNNLYGNADRSRPL 1162
            |                       .||.|......|.:.......|:|:...         :.||
  Fly  1384 AGDYSCHAENSIAKDSITHKLIVLAPPQSPHVTLSATTTDALTVKLKPHEGD---------TAPL 1439

  Fly  1163 HINTISGSLSQQQQLYTPS----RISRIFSSSPQQLQPHHQQLLLSSGGSGAYPTHFSDLST--- 1220
            |..|:.         |.|.    ..|.:...|    |.|:.:.||.......|.|.|:::..
  Fly  1440 HGYTLH---------YKPEFGEWETSEVSVDS----QKHNIEGLLCGSRYQVYATGFNNIGAGEA 1491

  Fly  1221 ---------------VYPPNSAERSSHNLSSRYRYYSQ-ELPSLRTIQEETRRQQ------QQKQ 1263
                           ...|...|.||:::|..::.:.. ..|....:.|..:|.|      ....
  Fly  1492 SDILNTRTKGQKPKLPEKPRFIEVSSNSVSLHFKAWKDGGCPMSHFVVESKKRDQIEWNQISNNV 1556

  Fly  1264 HPLEDHFVPLQLPSPPSWRSYYQSQASYRPRTRWYPRHHSRLFSNRQQQHEML-------SPL-- 1319
            .| ::::|.|.| .|.:|         |..|   ...|:|..|:..:.....|       :||
  Fly  1557 KP-DNNYVVLDL-EPATW---------YNLR---ITAHNSAGFTVAEYDFATLTVTGGTIAPLDD 1607

  Fly  1320 -----------------PQ-LNLNL---------------------------------------- 1326
                             |: |:||.
  Fly  1608 GSGHGNVHTRIRLPAWMPEWLDLNFMVPLIATVVVVAVGICVVCVALSRRRADDMRGGQKDVYYD 1672

  Fly  1327 ---RNSMNPG--------------GLEASPESRSSSSGFGSKNT------------SNHPGSTSE 1362
               ..:|.||              |..|.|..:.......:.||            |||    |.
  Fly  1673 VVYNQTMGPGATLDKRRPDLRDELGYIAPPNRKLPPVPGSNYNTCDRIKRGRGGLRSNH----ST 1733

  Fly  1363 W------RLLPPYRAPPSPPKHSGYFGGQQAQGQTPHGS----YSYPRATTP--PYTMAHWLEMI 1415
            |      .|....:||| .|.|..::|       ..||:    |.:|.....  ||...|.|...
  Fly  1734 WDPRRNPNLYEELKAPP-VPMHGNHYG-------HAHGNAECHYRHPGMEDEICPYATFHLLGFR 1790

  Fly  1416 SRLNAATDSNLPKAPCPVDVGSVDGHYEFDPATPTPS-ASSMLREDLNLHIDTHPYHHHTLGPLS 1479
            ..::.....|....|      ..:||     |.|.|. |.:||...       ||.|.|:   .|
  Fly  1791 EEMDPTKAMNFQTFP------HQNGH-----AGPVPGHAGTMLPPG-------HPGHVHS---RS 1834

  Fly  1480 GSLLHSHA-------PYGGGARKQRSLPAHLPRYDN 1508
            ||.....|       ..||    |.|:....|.||:
  Fly  1835 GSQSMPRANRYQRKNSQGG----QSSIYTPAPEYDD 1866

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tutl	NP_001303307.1	V-set	137..250	CDD:284989	23/114 (20%)
		IG_like	137..229	CDD:214653	19/93 (20%)
		I-set	253..341	CDD:254352	24/87 (28%)
		IGc2	268..331	CDD:197706	18/62 (29%)
		I-set	346..437	CDD:254352	19/104 (18%)
		Ig	349..437	CDD:299845	19/98 (19%)
		Ig	459..530	CDD:299845	22/78 (28%)
		IG_like	549..628	CDD:214653	20/86 (23%)
		IGc2	551..617	CDD:197706	19/73 (26%)
		FN3	633..725	CDD:238020	26/98 (27%)
		FN3	786..874	CDD:238020	23/90 (26%)
Dscam1	NP_001246162.1	Ig	38..130	CDD:299845
		IG	57..133	CDD:214652
		IG_like	267..343	CDD:214653
		Ig	269..340	CDD:143165
		IG_like	353..425	CDD:214653
		IGc2	361..413	CDD:197706
		I-set	433..527	CDD:254352	23/113 (20%)
		IGc2	446..517	CDD:197706	20/94 (21%)
		I-set	533..618	CDD:254352	23/89 (26%)
		IGc2	544..607	CDD:197706	18/62 (29%)
		Ig	641..714	CDD:143165	14/78 (18%)
		IGc2	735..804	CDD:197706	18/73 (25%)
		I-set	819..914	CDD:254352	24/99 (24%)
		Ig	833..921	CDD:299845	21/92 (23%)
		FN3	918..1011	CDD:238020	26/98 (27%)
		FN3	1018..1116	CDD:238020	12/102 (12%)
		FN3	1124..1217	CDD:238020	31/131 (24%)
		FN3	1222..1312	CDD:238020	21/145 (14%)
		Ig	1339..1406	CDD:299845	11/66 (17%)
		FN3	1409..1499	CDD:238020	21/111 (19%)
		FN3	1504..1584	CDD:238020	19/93 (20%)
		Dscam_C	1890..2008	CDD:289151
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10075
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910