DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tutl and LRIT3

DIOPT Version :9

Sequence 1:	NP_001303307.1	Gene:	tutl / 46015	FlyBaseID:	FBgn0010473	Length:	1536	Species:	Drosophila melanogaster
Sequence 2:	NP_940908.3	Gene:	LRIT3 / 345193	HGNCID:	24783	Length:	679	Species:	Homo sapiens

Alignment Length:	834	Identity:	156/834 - (18%)
Similarity:	257/834 - (30%)	Gaps:	329/834 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 RAEGSSICVPIRRGQGSTPTPTIQVLQFVLVSLLALLAKNAQAHNIPEDAVHITAILGEGVIFNC 150
            |.:|:|:..          .|...:|...|:..|.|  .|.:..::|.:|:.....|       .
Human   111 RLDGNSLAA----------FPWASLLDMPLLRTLDL--HNNKITSVPNEALRYLKNL-------A 156

  Fly   151 HVEFPNDH----PVPYVLQWDKKVSETGSDLPIYIWYESYPEHIEEGYKGRVSRVSQDSPFGSAS 211
            :::..::.    |..::..|...||.....|.:      .|..|..|.        ||:|
Human   157 YLDLSSNRLTTLPPDFLESWTHLVSTPSGVLDL------SPSRIILGL--------QDNP----- 202

  Fly   212 LNLTNIRESDQGWY-EC---KVVFLNR---------DP------KQHKNGTWF---HLDVHAPPR 254
                        |: :|   |::.|::         ||      .:...|..|   .|: |....
Human   203 ------------WFCDCHISKMIELSKVVDPAIVLLDPLMTCSEPERLTGILFQRAELE-HCLKP 254

  Fly   255 FSVTPEDIIYVNLGDSIILNCQADGTPTPEILWYK-DANPVD-----PSPTVGIFNDGTELRIST 313
            ..:|....|...||.:::|.|.|.|.|||:|.|.: |::||:     .||..|:  ..:.:.::.
Human   255 SVMTSATKIMSALGSNVLLRCDATGFPTPQITWTRSDSSPVNYTVIQESPEEGV--RWSIMSLTG 317

  Fly   314 IRHEDIGEYTCIARNGEGQVSHTARVIIAGGAVIMVPPTNQTKLEGEKVIFSCEAKAMPGN---- 374
            |..:|.|:|.|.|:|..|.......|.:.|.....:||..     .|:.....|....||:
Human   318 ISSKDAGDYKCKAKNLAGMSEAVVTVTVLGITTTPIPPDT-----SERTGDHPEWDVQPGSGRST 377

  Fly   375 -----VTVRWYREGSPVREVAALETRVTIRKDGSLIINPIKPDDSGQYLCEVTNGIGDPQSASAY 434
                 .:..|....||....:|                               :.:..|.:||..
Human   378 SVSSASSYLWSSSFSPTSSFSA-------------------------------STLSPPSTASFS 411

  Fly   435 LSVEYPAKVTFTPTVQYLPFRLAGVVQCYIKSSPQLQYVTWTKDKRLLEPYQ--MKDIVVMANGS 497
            ||....:.|:.|.|:                 |..:...|...:||..:.:|  .:::.|..|||
Human   412 LSPFSSSTVSSTTTL-----------------STSISASTTMANKRSFQLHQGGKRNLKVAKNGS 459

  Fly   498 LLFTRVNEEHQGQYACTPYNAQGTAGASGVMDVLVRKPPAFTVEPETLYQRKVGDSVEMHCDALE 562
            .|                                   |||.|.:.|.|              ||
Human   460 KL-----------------------------------PPASTSKKEEL--------------AL- 474

  Fly   563 AEGTERPTIKWQRQEGEQLTESQRNRIKISGGNITIENLRREDFGYYQCVVSNEVATLMAVTQLV 627
                         .:...|||:          |..|||||         |||.
Human   475 -------------LDQTMLTET----------NAAIENLR---------VVSE------------ 495

  Fly   628 IEGTQPHAPYNITGKATESSITLQWLPGYSGGSEYKQDYTIWFREAGVNDWQTISVTPSGSTQVT 692
                            |:.|:||.|   ....:.:....|:.:.:.|..|...:: ..|...|||
Human   496 ----------------TKESVTLTW---NMINTTHNSAVTVLYSKYGGKDLLLLN-ADSSKNQVT 540

  Fly   693 INGLASGTTYEFQVVGRNVLGDGMMSKVMTVRTLEDAPAAPRNVKAATQPPD------SFFQLMP 751
            |:||..|..|...|..:.|                 .|...:.:..:|:..:      |...::.
Human   541 IDGLEPGGQYMACVCPKGV-----------------PPQKDQCITFSTERVEGDDSQWSLLLVVT 588

  Fly   752 DEADLLAYFDIYFHTDSRGTLVYSPPKLRVKGPKPGPPRNVSVTEVSNGFLITWQSPLERAHIVK 816
            ..|.::....|.|       |:|...||:.|               |..|   |:..|.:...::
Human   589 STACVVILPLICF-------LLYKVCKLQCK---------------SEPF---WEDDLAKETYIQ 628

  Fly   817 FYTI-------------KYRTDAQWKTL-NRGQIRPEETQYLVKNLVGGRTYYF 856
            |.|:             .:|.|::...| :|..:   |:|...|: .|.|..|:
Human   629 FETLFPRSQSVGELWTRSHRDDSEKLLLCSRSSV---ESQVTFKS-EGSRPEYY 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tutl	NP_001303307.1	V-set	137..250	CDD:284989	21/138 (15%)
		IG_like	137..229	CDD:214653	14/99 (14%)
		I-set	253..341	CDD:254352	28/93 (30%)
		IGc2	268..331	CDD:197706	23/68 (34%)
		I-set	346..437	CDD:254352	14/99 (14%)
		Ig	349..437	CDD:299845	14/96 (15%)
		Ig	459..530	CDD:299845	10/72 (14%)
		IG_like	549..628	CDD:214653	14/78 (18%)
		IGc2	551..617	CDD:197706	14/65 (22%)
		FN3	633..725	CDD:238020	19/91 (21%)
		FN3	786..874	CDD:238020	16/85 (19%)
LRIT3	NP_940908.3	LRR 1	56..79
		leucine-rich repeat	59..82	CDD:275378
		LRR_8	61..117	CDD:290566	2/5 (40%)
		LRR 2	80..103
		leucine-rich repeat	83..106	CDD:275378
		LRR 3	104..128		5/26 (19%)
		LRR_8	105..165	CDD:290566	12/72 (17%)
		LRR_4	105..146	CDD:289563	9/46 (20%)
		leucine-rich repeat	107..130	CDD:275378	5/28 (18%)
		LRR 4	129..151		6/23 (26%)
		LRR_4	131..170	CDD:289563	6/47 (13%)
		leucine-rich repeat	131..154	CDD:275378	5/24 (21%)
		LRR 5	152..175		2/29 (7%)
		leucine-rich repeat	155..168	CDD:275378	1/19 (5%)
		Ig	267..345	CDD:299845	26/79 (33%)
		IG_like	267..345	CDD:214653	26/79 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	351..375		6/28 (21%)
		FN3	486..550	CDD:214495	24/104 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810