DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tutl and Mdga2

DIOPT Version :9

Sequence 1:	NP_001303307.1	Gene:	tutl / 46015	FlyBaseID:	FBgn0010473	Length:	1536	Species:	Drosophila melanogaster
Sequence 2:	NP_001180195.2	Gene:	Mdga2 / 320772	MGIID:	2444706	Length:	956	Species:	Mus musculus

Alignment Length:	890	Identity:	193/890 - (21%)
Similarity:	308/890 - (34%)	Gaps:	255/890 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 NTEKSKEQQ-----QQSQPLEI---------PEQRASKCRGDI-DRTTTTTIPASKTLTASPAKT 70
            |.|:.:..:     ::.:.||:         |:.|.:|..|.. ||...:::
Mouse    39 NIEEERYSERVYTIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSV------------- 90

  Fly    71 AAFTVKTTRRRRSRRRAEGSSICVPIRRGQGSTPTPTIQVLQFVLVSLLALLAKNAQAHNIPEDA 135
                ...|.|..:.:|.:|.........|.||....:|:|                ..:.:.:..
Mouse    91 ----FNETLRITNIQRHQGGRYYCKAENGLGSPAIKSIRV----------------DVYYLDDPV 135

  Fly   136 VHITAILGEG---------VIFNCHVEFPNDHPVPYVLQWDKKVSETGSDLPIYIWYESYPEHIE 191
            |.:...:||.         |...|...  ::.||.|..:..::|...|||..:.| ||
Mouse   136 VTVHQSIGEAKEQFYYERTVFLRCVAN--SNPPVRYSWRRGQEVLLQGSDKGVEI-YE------- 190

  Fly   192 EGYKGRVSRVSQDSPFGSAS----LNLTNIRESDQGWYEC------------KVVFLNRDPKQHK 240
                          ||.:..    |.|.|:|..|...|.|            |:|......|.
Mouse   191 --------------PFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKMVSFRLSNKT-- 239

  Fly   241 NGTWFHLDVHAPPRFSVTPEDIIYVNLGDSIILNC-QADGTPTPEILWYKDANPVDPSPTVGIFN 304
                      |.|...:..:|.|.||.|::|.|.| ...|.|||.:.|.:....:   |...:.|
Mouse   240 ----------ASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPTPSLTWVRSFGTL---PEKIVLN 291

  Fly   305 DGTELRISTIRHEDIGEYTCIARNGEGQVSHTARVIIAGG---AVIMVPPTNQTKLE----GEKV 362
            .|| |.|..|..:|.|.|:|||.|..|..:..:..||...   ....:.|....|.:    |.:|
Mouse   292 GGT-LTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREV 355

  Fly   363 IFSCEAKAMPG-NVTVRWYREGSPVREVAALETRVTIRKD-------GSLIINPIKPDDSGQYLC 419
            ..||:.:|:|. .:|..|::.|.|:|   :.|..|..:.|       .:|.|..:|..|.|.|.|
Mouse   356 KISCQVEAVPSEELTFSWFKNGRPLR---SSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTC 417

  Fly   420 EVT---NGIGDPQSASAYLSVEYPAKVTFTPTVQYLPFRLAGVV---------QCYIKSSPQLQY 472
            ..:   .||.|       :|::.....:..|....:|...:.:|         ||.:...|: ..
Mouse   418 VASLKGGGISD-------ISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPK-PI 474

  Fly   473 VTWTK-DKRLLEP---YQMKDIVVMANGSLLFTRVNEEHQGQYAC--TPYNAQGTAGASGVMDVL 531
            :.|:: ||.:..|   .||:..    :|:|....|:.|..|.|.|  :.||.........::.::
Mouse   475 ILWSRADKEVAMPDGTMQMESY----DGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLI 535

  Fly   532 VRKPPAFTVEPETLYQRKVGD-SVEMHCDALEAEGTERPTIKWQ---------RQEGEQLTESQR 586
            |:.|||  |||..|..|:..| ||.|.|..|.|......|.:|:         :.:.::.||
Mouse   536 VQYPPA--VEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTE--- 595

  Fly   587 NRIKISGGNITIENLRREDFGYYQCVVSNEVATLMAVTQLVIEGTQPHAPYNITGKATES----- 646
                     ..:::|..|::|.|.|.:.||...             ....:.:||||...
Mouse   596 ---------YPLKSLSNENYGVYNCSIINEAGA-------------GRCSFLVTGKAYAPEFYYD 638

  Fly   647 -------------SITLQWLPGYSGGSEYKQDYTIWFREAGVNDWQTISVTPSGSTQ----VTIN 694
                         |.:|||........:....|.:..|:||...|....:..:|:.|    :|.|
Mouse   639 TYNPVWQNRHRVYSYSLQWTQMNPDAVDRIVAYRLGIRQAGQQRWWEQEIKINGNIQKGELITYN 703

  Fly   695 --GLASGTTYEFQVVGRNVLGDGMMSKVMTVRTLE-DAPAAPR-----------NVKAATQPPDS 745
              .|.....||.::......|:|    ..|:|.:: .||..|.           |:...||
Mouse   704 LTELIKPEAYEVRLTPLTKFGEG----DSTIRVIKYTAPVNPHLREFHCGFEDGNICLFTQ---- 760

  Fly   746 FFQLMPDEADLLAYFDIYFHTDSRGTLVYSP---PKLRVKGPKPG 787
                  |:.|   .||....:.:.....|:|   |.....|.|.|
Mouse   761 ------DDTD---NFDWTKQSTATRNTKYTPNTGPSADRSGSKEG 796

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tutl	NP_001303307.1	V-set	137..250	CDD:284989	26/137 (19%)
		IG_like	137..229	CDD:214653	23/116 (20%)
		I-set	253..341	CDD:254352	29/88 (33%)
		IGc2	268..331	CDD:197706	23/63 (37%)
		I-set	346..437	CDD:254352	26/105 (25%)
		Ig	349..437	CDD:299845	26/102 (25%)
		Ig	459..530	CDD:299845	19/85 (22%)
		IG_like	549..628	CDD:214653	18/88 (20%)
		IGc2	551..617	CDD:197706	17/75 (23%)
		FN3	633..725	CDD:238020	23/115 (20%)
		FN3	786..874	CDD:238020	1/2 (50%)
Mdga2	NP_001180195.2	IG_like	48..128	CDD:214653	17/112 (15%)
		IGc2	54..117	CDD:197706	13/79 (16%)
		IG_like	154..219	CDD:214653	21/88 (24%)
		Ig	155..219	CDD:143165	21/87 (24%)
		IG_like	251..328	CDD:214653	28/80 (35%)
		IGc2	256..317	CDD:197706	23/64 (36%)
		Ig	355..427	CDD:143165	21/74 (28%)
		IG_like	451..536	CDD:214653	19/89 (21%)
		IGc2	457..522	CDD:197706	17/69 (25%)
		Ig_2	543..618	CDD:290606	22/86 (26%)
		MAM	748..921	CDD:279023	13/62 (21%)
		MAM	748..919	CDD:99706	13/62 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000