DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tutl and Nrcam

DIOPT Version :9

Sequence 1:	NP_001303307.1	Gene:	tutl / 46015	FlyBaseID:	FBgn0010473	Length:	1536	Species:	Drosophila melanogaster
Sequence 2:	XP_006516011.1	Gene:	Nrcam / 319504	MGIID:	104750	Length:	1308	Species:	Mus musculus

Alignment Length:	1301	Identity:	272/1301 - (20%)
Similarity:	431/1301 - (33%)	Gaps:	382/1301 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 DIDRTTTTTI-PASKTLT---ASPAKTAAFT-VKTTRRRRSRRRAEGSSICV-PIRRGQGSTPTP 106
            |||:....|: |.|.||.   .|..|...:. |.....|..|..|..::|.| |.|     :|..
Mouse    88 DIDKDPLVTMKPGSGTLVINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSR-----SPLW 147

  Fly   107 TIQVLQFVLVSLLALLAKNAQAHNIPEDAVHITAILGEGVIF---NCHVEFPNDHPVPYVLQWDK 168
            |.:.|:       .::.:|.|:..:|   ......|...:||   |.....|....|...|..|.
Mouse   148 TKERLE-------PIVLQNGQSLVLP---CRPPIGLPPAIIFWMDNSFQRLPQSERVSQGLNGDL 202

  Fly   169 KVS-----ETGSDLPIYIWYESYPEHIEEGYKGRVSRVSQDSPFGSASLNLTNIRE--------- 219
            ..|     :|..|   ||.|..:         .....:.|..|.   ||.:.::.|
Mouse   203 YFSNVLPEDTRED---YICYARF---------NHTQTIQQKQPI---SLKVISVDELNDTIAANL 252

  Fly   220 SDQGWYECKVVFLNRDPKQHKNGTWFHLDVHAPPRFSVTPEDIIYVN-------LGDSIILNCQA 277
            ||..:|..|      ..|:.            ||.| :|||.    |       .|:.:.|.|.|
Mouse   253 SDTEFYGAK------SSKER------------PPTF-LTPEG----NESHKEELRGNVLSLECIA 294

  Fly   278 DGTPTPEILWYKDANPVDPSPTVGIFNDGTELRISTIRHEDIGEYTCIARNGEGQVSHTARVIIA 342
            :|.|||.|.|.|:...: |:......|....|:|:.:...|.|.|.|||:|..|.|.||..|.:.
Mouse   295 EGLPTPIIYWIKEDGML-PANRTFYRNFKKTLQITHVSEADSGNYQCIAKNALGAVHHTISVTVK 358

  Fly   343 GGAVIMVPPTNQTKLEGEKVIFSCEAKAMPGNVTVRWYREGSPVREVAALETRVTIRKDGSLIIN 407
            .....:|.|.|.....||.....|.|...| ...:.|...|.|: |:|..:....|..| ::|.:
Mouse   359 AAPYWIVAPQNLVLSPGENGTLICRANGNP-KPRISWLTNGVPI-EIALDDPSRKIDGD-TIIFS 420

  Fly   408 PIKPDDSGQYLCEVTNGIGDPQSASAYLSV--EYPAKVTFTPTVQYLPFRLAGVVQCYIKSSPQ- 469
            .::...|..|.|..:|..| ...|:|:::|  |.|..:|...|:..:......::.|....||.
Mouse   421 NVQESSSAVYQCNASNKYG-YLLANAFVNVLAEPPRILTSANTLYQVIANRPALLDCAFFGSPMP 484

  Fly   470 -LQYVTWTKDKRLLEPYQMKDIVVM-ANGSLLFTRVNEEHQGQYACTPYNAQGTAGASGVMDVLV 532
             :::...||...|.|     ||.|: .||:|......::..|.|.|...|..|.  |...:.:.:
Mouse   485 TIEWFKGTKGSALHE-----DIYVLHDNGTLEIPVAQKDSTGTYTCVARNKLGM--AKNEVHLEI 542

  Fly   533 RKPPAFTVEPE-TLYQRKVGDSVEMHCDALEAEGTERPTIKWQRQEGEQLTESQRNRIKISGGNI 596
            :.|.....:|| .:.||  |..|...| .::.:.|..|||.|.:..||...:   .|......::
Mouse   543 KDPTRIIKQPEYAVVQR--GSKVSFEC-RVKHDHTLIPTIMWLKDNGELPND---ERFSTDKDHL 601

  Fly   597 TIENLRREDFGYYQCVVSN--EVATLMAVTQLVIEGTQPHAPYNITG--------KATESSITLQ 651
            .:.:::.:|.|.|.|..:.  :.|:..||.::|.....|...|::..        ...:.|:.|.
Mouse   602 VVSDVKDDDGGTYTCTANTTLDSASASAVLRVVAPTPTPAPIYDVPNPPFDLELTNQLDKSVQLT 666

  Fly   652 WLPGYSGGS-------EYK---QDYTIWFREAGVNDWQTI-----------------------SV 683
            |.||....|       ||:   .|..:|..:|.|:..||.                       |:
Mouse   667 WTPGDDNNSPITKFIIEYEDAMHDAGLWRHQAEVSGTQTTAQLKLSPYVNYSFRVMAENSIGRSM 731

  Fly   684 TPSGSTQ------------VTINGL------------------ASGTTYEFQVVGRNVLGDGMMS 718
            ....|.|            :.:.||                  ::|...:::|..|...||...:
Mouse   732 PSEASEQYLTKAAEPDQNPMAVEGLGTEPDNLVITWKPLNGFQSNGPGLQYKVSWRQKDGDDEWT 796

  Fly   719 KVMT--------------------VRTL-----------------EDAP-AAPRNVKAAT----- 740
            .|:.                    |:.|                 ||.| .||.||:.:.
Mouse   797 SVVVANVSKYIVSGTPTFVPYLIKVQALNDVGFAPEPAAVMGHSGEDLPMVAPGNVRVSVVNSTL 861

  Fly   741 -------QPPDSFFQLMPDEADLLAYFDIYFHTDS----------------RGTLV--------- 773
                   .||.|.      ...|..|...|:.|.|                :||..
Mouse   862 AEVHWDPVPPKSV------RGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGTKTHGMLPGLQP 920

  Fly   774 YSPPKLRVK-------GPK------------PGPPRNVSVTEVS-NGFLITWQSPLERAHIVKFY 818
            ||...|.|:       ||.            |..|.::.:...: :...:.|..|.....|:..|
Mouse   921 YSHYALNVRVVNGKGEGPASTDRGFHTPEGVPSAPSSLKIVNPTLDSLTLEWDPPSHPNGILTEY 985

  Fly   819 TIKYR---TDAQWKTLNRGQIRPEETQYLVKNLVGGRTYYFRVLAN---------SEKSYESSDE 871
            .::|:   :..:...|...:|...:|::.:|||.....|.|...|.         :|::..:.||
Mouse   986 ILQYQPINSTHELGPLVDLKIPANKTRWTLKNLNFSTRYKFYFYAQTSVGPGSQITEEAITTVDE 1050

  Fly   872 VKFPVP-----------ARVKHKAITAGVV-----------GGILFFIVAIILSVCAVKICNKRK 914
            ...|.|           .|:.:...||...           |.:.|::...:..       :|.:
Mouse  1051 AGIPPPDVGAGKVRAVNPRISNLTATAAETYANITWEYEGPGHVTFYVEYGVAG-------SKEE 1108

  Fly   915 RRKQ-----EKEFNMVACRITDARNIAANNHHLHNRSTGSISSGQV----PLKKYKQTRISS--- 967
            .||:     ...|.:.......|..:...    ....:|.:||..|    |....:|..|::
Mouse  1109 WRKEIVNGSRSFFGLKGLMPGTAYKVRVG----AEGDSGFVSSEDVFETGPAMASRQVDIATQGW 1169

  Fly   968 ------LTAILIAILHWI----------WPPDRCTNCHSIYSSPNLEDGDEDDGGGGRRRSVSRI 1016
                  ..|:||.||..:          :|.....:.|   :.|.::...||||..|..||
Mouse  1170 FIGLMCAVALLILILLIVCFIRRNKGGKYPVKEKEDAH---ADPEIQPMKEDDGTFGEYRS---- 1227

  Fly  1017 QRSLDGRFVLDVEGVSKLGYSQQT-------LESGNVDVVDGGLFERRNSNVSQKSSSDDGGFLS 1074
                   |..|.|....|....:|       .|..:..:||.|  |..|...     ::||.|:.
Mouse  1228 -------FESDAEDHKPLKKGSRTPSDRTVKKEDSDDSLVDYG--EGVNGQF-----NEDGSFIG 1278

  Fly  1075 R 1075
            :
Mouse  1279 Q 1279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tutl	NP_001303307.1	V-set	137..250	CDD:284989	24/129 (19%)
		IG_like	137..229	CDD:214653	22/108 (20%)
		I-set	253..341	CDD:254352	33/94 (35%)
		IGc2	268..331	CDD:197706	22/62 (35%)
		I-set	346..437	CDD:254352	23/90 (26%)
		Ig	349..437	CDD:299845	23/87 (26%)
		Ig	459..530	CDD:299845	19/73 (26%)
		IG_like	549..628	CDD:214653	18/80 (23%)
		IGc2	551..617	CDD:197706	15/67 (22%)
		FN3	633..725	CDD:238020	28/182 (15%)
		FN3	786..874	CDD:238020	19/100 (19%)
Nrcam	XP_006516011.1	Ig_NrCAM	64..140	CDD:143282	15/51 (29%)
		Ig	145..237	CDD:386229	23/116 (20%)
		Ig	288..358	CDD:386229	26/70 (37%)
		Ig4_NrCAM	375..450	CDD:143276	20/78 (26%)
		IGc2	469..532	CDD:197706	17/67 (25%)
		Ig	547..633	CDD:386229	22/91 (24%)
		FN3	647..737	CDD:238020	15/89 (17%)
		fn3	750..832	CDD:365830	10/81 (12%)
		fn3	848..938	CDD:365830	18/95 (19%)
		fn3	953..1037	CDD:365830	15/83 (18%)
		fn3	1068..1136	CDD:365830	10/74 (14%)
		Bravo_FIGEY	1191..1280	CDD:372781	24/110 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910