DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tutl and Igsf9b

DIOPT Version :9

Sequence 1:	NP_001303307.1	Gene:	tutl / 46015	FlyBaseID:	FBgn0010473	Length:	1536	Species:	Drosophila melanogaster
Sequence 2:	NP_001363879.1	Gene:	Igsf9b / 315510	RGDID:	1564717	Length:	1441	Species:	Rattus norvegicus

Alignment Length:	1495	Identity:	396/1495 - (26%)
Similarity:	603/1495 - (40%)	Gaps:	347/1495 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 LVSLLALLAKNAQAHNIPEDAVHITAILGEGVIFNCHVEFP-NDHPVPYVLQWDKKVSETGSDLP 178
            ::|...|:|:  .||.:.|:...:||..||||:..|.|..| ...|.|||::|.|    .|..:|
  Rat    12 VISTRGLVAQ--VAHGLREEPEFVTARAGEGVVLRCDVIHPVTGQPPPYVVEWFK----FGVPIP 70

  Fly   179 IYIWYESYPEHIEEGYKGRVSRVSQDSPFGSASLNLTNIRESDQGWYECKVVFLNRDPKQHKNGT 243
            |:|.:..||.|::..|.||.|.      ...|||.|..:|..|||||||||:.|::......||:
  Rat    71 IFIKFGYYPPHVDPEYAGRASL------HDKASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGS 129

  Fly   244 WFHLDVHAPPRFSVTPEDIIYVNLGDSIILNCQADGTPTPEILWYKDANPVDPSPTVGIFNDGTE 308
            |.||.::|||.|:.||...|....|.||.:.|.|.|.|.|.:.|.|:...:..|....: :||:
  Rat   130 WVHLTINAPPTFTETPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLSASGKYQV-SDGS- 192

  Fly   309 LRISTIRHEDIGEYTCIARNGEGQVSHTARVIIAGGAVIMVPPTNQTKLEGEKVIFSCEAKAMPG 373
            |.::::..||.|.|||.|.:.:|:..||..:::.|...|:.||.|.|....:..:.:|.|:|.||
  Rat   193 LTVTSVSREDRGAYTCRAYSIQGEAVHTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYPG 257

  Fly   374 NVTVRWYREGSPVREVAALETRVTIRKDGSLIINPIKPDDSGQYLCEVTNGIGDPQSASAYLSVE 438
            |:|..||.:...|.....|:.||.|..||:|||..:||:|:|:|.|..:|.:|...||||||:|:
  Rat   258 NLTYTWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDAGKYTCVPSNSLGRSPSASAYLTVQ 322

  Fly   439 YPAKVTFTPTVQYLPFRLAGVVQCYIKSSPQLQYVTWTKDKRLLEPYQMKDIVVMANGSLLFTRV 503
            |||:|...|.|.|:|..:.|.::|.:.:.|....|.|.||.|.|:..:.....:|.:||:.....
  Rat   323 YPARVLNMPPVIYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGWTLMEDGSIRIEEA 387

  Fly   504 NEEHQGQYACTPYNAQGTAGASGVMDVLVRKPPAFTVEPETLYQRKVGDSVEMHCDALEAEGTER 568
            .||..|.|.|.|||..||.|.|....::::.||.|||.|...|:::.|..:.:.|   .|.|...
  Rat   388 TEEALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQEAGRELLIPC---AAAGDPF 449

  Fly   569 PTIKWQRQEGEQLTESQRNRIKISGGNITIENLRREDFGYYQCVVSNEVATLMAVTQLVIEGTQP 633
            |.|.| |:.|:. :.|:.|  .:..|::....|.:||.|.::||.:|.|.::.|.|.|.:.||.|
  Rat   450 PVITW-RKVGKP-SRSKHN--ALPSGSLQFRALSKEDHGEWECVATNVVTSITASTHLTVIGTSP 510

  Fly   634 HAPYNITGKATESSITLQWLPGYSGGSEYKQDYTIWF------REAGVNDWQTISVTPSGSTQVT 692
            |||.::....:.::..:.|.|||.||  |:|.:::|:      .:.|.:||.::|| |.|.:.:.
  Rat   511 HAPGSVRVHVSMTTANVSWEPGYDGG--YEQTFSVWYGPLMKRAQFGPHDWLSLSV-PLGPSWLL 572

  Fly   693 INGLASGTTYEFQVVGRNVLGDGMMSKVMTVRTLEDAPAAPRNVKAATQPPDSFFQLMPDEADLL 757
            ::.|...|.|:|.|:.:|.||....|:|:||.||......|..:...|
  Rat   573 VDSLEPETAYQFSVLAQNRLGTSAFSEVVTVNTLAFPVTTPEPLVLVT----------------- 620

  Fly   758 AYFDIYFHTDSRGTLVYSPPKLRVKGPKPGPPRNVSVTEVSNGFLITWQSPLERAHIVKFYTIKY 822
                                          |||.::......|.|::|..|...:..:..|.:::
  Rat   621 ------------------------------PPRCLTANRTQQGVLLSWLPPANHSFPIDRYIMEF 655

  Fly   823 RTDAQWKTLNRGQIRPEETQYLVKNLVGGRTYYFRVLA-----NSEKSY---ESSDEVKFPVPAR 879
            |...:|:.|: ..|...:.::..|:|.....|.|||||     .||.|.   .||.:: ||.|..
  Rat   656 RVGERWEMLD-DAIPGTDGEFFAKDLSQDTWYEFRVLAVMQDLISEPSNIAGVSSTDI-FPQPDL 718

  Fly   880 VKH---KAITAGVVGGILFFIVAIILSVCAVKICNKRKRRKQEKE----FNMVACR------ITD 931
            ...   :.:.||:|..|.|...||:.|..|....||:::||.:::    .::..||      ::.
  Rat   719 TDDGLARPVLAGIVATICFLAAAILFSTLAACFVNKQRKRKLKRKKDPPLSITHCRKSLESPLSS 783

  Fly   932 ARNIAANNHHLHNRSTGSISSGQVPLKK------------YKQTR--ISSLTAILIAILHWIWPP 982
            .:....:...|...|..|...||...|:            ||:|:  |||..
  Rat   784 GKVSPESIRTLRAPSESSDDQGQPAAKRMLSPTREKELSLYKKTKRAISSRK------------- 835

  Fly   983 DRCTNCHSIYSSPNLEDGDEDDGGGGRRRSVSRIQRSLDGRFVLDVEGVSKLGYSQQTLESGNVD 1047
                     ||....|...|      ....:..|.|..|||||:   |.|::..|.:...
  Rat   836 ---------YSVAKAEAEAE------ATTPIELISRGPDGRFVM---GPSEMEPSVKGRR----- 877

  Fly  1048 VVDGGLFERRNSNVSQKSSSDDGGFLSRRNFITARASWRRPLVASS-----SQLS-LQSAADS-- 1104
             ::|..|........:...||:..              ..|||.:|     .||: :.|:.||
  Rat   878 -IEGFPFAEETDMYPEFRQSDEEN--------------EDPLVPTSVAALKPQLTPMSSSQDSYL 927

  Fly  1105 ----------ARGFLQGLLKIGAKQSAV----PPNSQSYFDEAVSGARYQNVLRPYTSSNNLYGN 1155
                      .|| |:|...:|.:..|.    ||                 ..||: .....||.
  Rat   928 PPPAYSPRFQPRG-LEGPSGLGGRLQATGQARPP-----------------APRPF-QHGQYYGY 973

  Fly  1156 ADRSRPLHINTISGSLSQQQQLYTP---SRISRIFSSSPQQLQ-PHHQQLLLSSGGSGA------ 1210
            ...|.|..:        :....|.|   |.:|.:.||.|...: |.....:....|..|
  Rat   974 LSSSSPGEV--------EPPPFYMPEVGSPLSSVMSSPPLHTEGPFGHPTIPEENGENASNSTLP 1030

  Fly  1211 ---YPT-------------HFSDLST--------VYPPNSAERSS------HNLSSRYRYYSQEL 1245
               .||             .|..|.|        ::|.:.||...      ..|...........
  Rat  1031 LTQTPTGGRSPEPWGRPEFPFGGLETPAMMFPHQLHPCDVAESLQPKPCLPRGLPPAPLQVPAAY 1095

  Fly  1246 PSLRTIQ-----------------------EETRRQ----QQQKQHPLEDHFVPLQLPSP-PSWR 1282
            |.:.:::                       :|...|    |.|.:|..:...:|: ||.| |:..
  Rat  1096 PGMLSLEAPKGWVGKSPGRGPIPAPPATKWQERPMQPLVSQGQLRHTSQGMGIPV-LPYPEPAEP 1159

  Fly  1283 SYYQSQASYRPRTRWY---------PRHHSRLFSNRQQ---QHEMLSPLPQLNLNLRNSM----- 1330
            ..:...:::...||||         ||...|...:..|   |...||||.|..|:.|...
  Rat  1160 GGHGGPSTFGLDTRWYEPQPRPRPSPRQARRAEPSLHQVVLQPSRLSPLTQSPLSSRTGSPELAA 1224

  Fly  1331 ----NPGGLEASPES--------------RSSSSGFGSKNTSNHPGSTSEWRLL----------- 1366
                .||.|:.:..|              :|:.|..||.:.|:..||.|....:
  Rat  1225 RARPRPGLLQQAEMSEITLQPPAAVSFSRKSTPSSTGSPSQSSRSGSPSYRPTMGFTTLATGYPS 1289

  Fly  1367 -PPYRAPPSPPKHSGYFGGQQAQGQTPHGSYSYPRATTPPYTMAHWLEMISRLNAATDSNLPKAP 1430
             ||..|||:|..:...||    |..:|......|....||.|:            .|...||.||
  Rat  1290 PPPGPAPPAPGDNLDVFG----QTPSPRRMGEEPLRPEPPTTL------------PTSGILPPAP 1338

Fly 1431 1430
Rat 1339 1338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tutl	NP_001303307.1	V-set	137..250	CDD:284989	46/113 (41%)
		IG_like	137..229	CDD:214653	38/92 (41%)
		I-set	253..341	CDD:254352	29/87 (33%)
		IGc2	268..331	CDD:197706	21/62 (34%)
		I-set	346..437	CDD:254352	38/90 (42%)
		Ig	349..437	CDD:299845	37/87 (43%)
		Ig	459..530	CDD:299845	23/70 (33%)
		IG_like	549..628	CDD:214653	23/78 (29%)
		IGc2	551..617	CDD:197706	19/65 (29%)
		FN3	633..725	CDD:238020	32/97 (33%)
		FN3	786..874	CDD:238020	25/95 (26%)
Igsf9b	NP_001363879.1	PHA03247	<898..1246	CDD:223021	73/389 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	918..1044		29/152 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1111..1332		53/237 (22%)
		Ig	41..115	CDD:319273	33/83 (40%)
		I-set	139..225	CDD:369462	29/87 (33%)
		Ig	229..321	CDD:386229	38/91 (42%)
		Ig	<353..414	CDD:386229	21/60 (35%)
		Ig	438..502	CDD:319273	20/70 (29%)
		FN3	510..605	CDD:238020	32/97 (33%)
		FN3	621..703	CDD:238020	22/82 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	762..821		8/58 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	74	1.000	Domainoid score	I8897
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	462	1.000	Inparanoid score	I1494
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D151368at33208
OrthoFinder	1	1.000	-	-		FOG0002337
OrthoInspector	1	1.000	-	-		otm44898
orthoMCL	1	0.900	-	-		OOG6_104975
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1123
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.730