DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment tutl and Ncam2

DIOPT Version :9

Sequence 1:NP_001303307.1 Gene:tutl / 46015 FlyBaseID:FBgn0010473 Length:1536 Species:Drosophila melanogaster
Sequence 2:NP_981954.2 Gene:Ncam2 / 288280 RGDID:1303131 Length:837 Species:Rattus norvegicus


Alignment Length:982 Identity:198/982 - (20%)
Similarity:333/982 - (33%) Gaps:291/982 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   118 LLALLAKNAQAHNIPEDAVHITAI---LGEGVIFNCHVEFPNDHPVPYVLQWDKKVSETGSDLPI 179
            ||.||..:.||  :.:..:.::.:   :||...|.|                      |....|.
  Rat     9 LLGLLVSSGQA--LLQVTISLSKVELSVGESKFFTC----------------------TAIGEPE 49

  Fly   180 YI-WYESYPEHI---------EEGYKGRVSRVSQDSPFGSASLNLTNIRESDQGWYECKVVFLNR 234
            .| ||....|.|         :||.:.|              |.:.|....|.|.|.|:..    
  Rat    50 SIDWYNPQGEKIISTQRVMLQKEGVRSR--------------LTIYNANIEDAGIYRCQAT---- 96

  Fly   235 DPKQHKNGTWFHLDVHAPPRFS--VTPEDIIYVNLGDSIILNCQADGTPTPEILWY---KDANPV 294
            |.|.........|:::....|.  ::|::.   ..|:...:.|:...:|.|.:.|.   ::...:
  Rat    97 DAKGQTQEATVVLEIYQKLTFREVLSPQEF---KQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTI 158

  Fly   295 DPSPTVGIFNDGTELRISTIRHEDIGEYTCIAR-NGEGQVSHTARVIIAGGAVIMVPPT------ 352
            ..:....:.|:  .|:|..|...|.|.|.|..| ...|::.....::|     :.|||.      
  Rat   159 PDNRFAVLANN--NLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVI-----VNVPPAIVMPQK 216

  Fly   353 --NQTKLEGEKVIFSCEAKAMPGNVTVRWYREGSPVRE-----VAALETRVTIRKDGSLIINPIK 410
              |.|...||::..:|:|...| :..:.|:|.|..:.|     :....|.:|:|.    |||   
  Rat   217 SFNATAERGEEMTLTCKASGSP-DPAISWFRNGKLIEENEKYILKGSNTELTVRN----IIN--- 273

  Fly   411 PDDSGQYLCEVTNGIGDPQSASAYLSVEYPAKVTFTPTVQYLPFRLAG-----VVQCYIKSSPQL 470
             .|.|.|:|:.||..|:.|. .|:|      :|...|.:..|......     .:.|..:..| :
  Rat   274 -KDGGSYVCKATNKAGEDQK-QAFL------QVFVQPHILQLKNETTSENGHVTLICEAEGEP-V 329

  Fly   471 QYVTWTKDKRLLEPYQMKDIVVMANG-----------------SLLFTRVNEEHQGQYACTPYNA 518
            ..:||   ||.:      |.|..:.|                 ||....|.....|:|.|..  |
  Rat   330 PEITW---KRAI------DGVTFSEGDKSPDGRIEVKGQHGRSSLHIRDVKLSDSGRYDCEA--A 383

  Fly   519 QGTAGASGVMDVLVRKPPAFTVEPETLYQRKVGDSVEMHCDALEAEGTERPTIKWQRQEGEQLTE 583
            ....|....|.:.:...|.| |..:|:|....|:.:.:.||   .:.....:|.|:|   |:|..
  Rat   384 SRIGGHQRSMHLDIEYAPKF-VSNQTMYYSWEGNPINISCD---VKANPPASIHWRR---EKLVL 441

  Fly   584 SQRNRIKISGGNI----------TIENLRREDFGYYQCVVSNEVATLMAVTQLVIE-GTQPHAPY 637
            ..:|...:...::          |.:|    |||.|.|..:|.:.|  ...:.::| ...|.:|.
  Rat   442 PAKNTTHLKTHSVGRKMILEIAPTSDN----DFGRYNCTATNRIGT--RFQEYILELADVPSSPR 500

  Fly   638 NITGKATESSITLQWL----PGYSGGSEYKQDYTIWFREAGVNDWQTISVTPSGSTQVTINGLAS 698
            .:  |..|.|.|...:    |...||... ..|.:..:|.....|:.:. :....|.|.::.|..
  Rat   501 GV--KIIELSQTTAKISFNKPESHGGVPI-HHYQVDVKEVTSETWKIVR-SHGVQTTVVLSSLEP 561

  Fly   699 GTTYEFQVVGRNVLGDGMMSKVMTVRTLEDAPAAPRNVKAATQPPDSFFQLMPDEADLLAYFDIY 763
            .||||.:|...|..|.|..||:                        ..||.:|....        
  Rat   562 NTTYEVRVAAVNGKGQGDYSKI------------------------EIFQTLPVREP-------- 594

  Fly   764 FHTDSRGTLVYSPPKLRVKGPKPGPPRNVSVTEVSNGFLITWQSPLERAHIVKFYTIKYRTDAQW 828
                       |||.:..: |..|....:|:|:..:|          .|.|:: |.:|||:    
  Rat   595 -----------SPPSIHGQ-PSSGKSFKISITKQDDG----------GAPILE-YIVKYRS---- 632

  Fly   829 KTLNRGQIRPEETQYLVKNLVGGRT------------YYFRVLANSEKSYESSDEVKFPVPAR-- 879
                    :.:|.|:|.|.:.|.:.            |..::.|.:...|......:|.:|.:  
  Rat   633 --------KDKEDQWLEKKVQGNKDHIILEHLQWTMGYEVQITAANRLGYSEPTVYEFSMPPKPN 689

  Fly   880 -VKHKAITAGVVGGILFFIVAIILSVCAV-------------------KICNKRK----RRKQEK 920
             :|........:|.|:...||.:|.:..|                   ::|.|:.    :.|:.:
  Rat   690 IIKDTLFNGLGLGAIIGLGVAALLLILVVTDVSCFFIRQCGLLMCITRRMCGKKSGSSGKSKELE 754

  Fly   921 EFN-----------MVACRITDARNIAANNH------HLHNRSTGSISSGQVPLKKYKQTRISSL 968
            |..           :|..|..|.|   ..||      :..|.:|......::|||:.....:.:.
  Rat   755 EGKAAYLKDGSKEPIVEMRTEDER---ITNHEDGSPVNEPNETTPLTEPEKLPLKEENGKEVLNA 816

  Fly   969 TAILIAI 975
            ..|.|.:
  Rat   817 ETIEIKV 823

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tutlNP_001303307.1 V-set 137..250 CDD:284989 23/125 (18%)
IG_like 137..229 CDD:214653 20/104 (19%)
I-set 253..341 CDD:254352 17/93 (18%)
IGc2 268..331 CDD:197706 14/66 (21%)
I-set 346..437 CDD:254352 30/103 (29%)
Ig 349..437 CDD:299845 30/100 (30%)
Ig 459..530 CDD:299845 18/87 (21%)
IG_like 549..628 CDD:214653 18/88 (20%)
IGc2 551..617 CDD:197706 17/75 (23%)
FN3 633..725 CDD:238020 25/95 (26%)
FN3 786..874 CDD:238020 18/99 (18%)
Ncam2NP_981954.2 IgI_1_NCAM-2 21..113 CDD:409452 23/131 (18%)
Ig strand B 38..42 CDD:409452 1/3 (33%)
Ig strand C 50..54 CDD:409452 1/3 (33%)
Ig strand E 76..80 CDD:409452 2/17 (12%)
Ig strand F 90..95 CDD:409452 2/4 (50%)
Ig strand G 104..107 CDD:409452 0/2 (0%)
IGc2 128..189 CDD:197706 13/62 (21%)
Ig strand B 130..139 CDD:409353 1/8 (13%)
Ig strand C 145..153 CDD:409353 1/7 (14%)
Ig strand C' 156..159 CDD:409353 0/2 (0%)
Ig strand D 162..167 CDD:409353 0/4 (0%)
Ig strand E 168..175 CDD:409353 3/8 (38%)
IgI_1_MuSK 209..298 CDD:409562 28/104 (27%)
Ig strand B 228..232 CDD:409562 0/3 (0%)
Ig strand C 241..245 CDD:409562 0/3 (0%)
Ig strand E 264..268 CDD:409562 1/3 (33%)
Ig strand F 278..283 CDD:409562 2/4 (50%)
Ig strand G 291..294 CDD:409562 1/3 (33%)
Ig 300..397 CDD:416386 20/108 (19%)
Ig strand A 300..305 CDD:409353 1/4 (25%)
Ig strand A' 309..313 CDD:409353 0/3 (0%)
Ig strand B 317..325 CDD:409353 1/7 (14%)
Ig strand C 331..337 CDD:409353 3/8 (38%)
Ig strand C' 340..343 CDD:409353 1/2 (50%)
Ig strand D 353..359 CDD:409353 0/5 (0%)
Ig strand E 362..368 CDD:409353 2/5 (40%)
Ig strand F 376..384 CDD:409353 3/9 (33%)
Ig strand G 387..397 CDD:409353 2/9 (22%)
Ig_3 401..479 CDD:404760 21/88 (24%)
Ig strand B 418..422 CDD:409353 0/3 (0%)
Ig strand C 431..435 CDD:409353 1/3 (33%)
Ig strand E 458..462 CDD:409353 0/3 (0%)
Ig strand F 472..477 CDD:409353 2/4 (50%)
Ig strand G 486..489 CDD:409353 0/2 (0%)
FN3 496..588 CDD:238020 26/119 (22%)
fn3 594..678 CDD:394996 22/126 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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