DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tutl and MDGA1

DIOPT Version :9

Sequence 1:	NP_001303307.1	Gene:	tutl / 46015	FlyBaseID:	FBgn0010473	Length:	1536	Species:	Drosophila melanogaster
Sequence 2:	XP_006715119.1	Gene:	MDGA1 / 266727	HGNCID:	19267	Length:	973	Species:	Homo sapiens

Alignment Length:	859	Identity:	191/859 - (22%)
Similarity:	310/859 - (36%)	Gaps:	193/859 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 TLTASPA-----KTAAFTVKTTRRRRSRRRAEGSSICVPIRRGQGSTPTPTIQVLQFVLVSLLAL 121
            |.||..|     :|:.|. :|.|..|..|...|...|    :.:.....|.|:.::.
Human    73 TKTAGSASDKFQETSVFN-ETLRIERIARTQGGRYYC----KAENGVGVPAIKSIRV-------- 124

  Fly   122 LAKNAQAHNIPEDAVHITAILGEG-------VIFNCHVEFPNDHPVPYVLQWDKKVSET------ 173
               :.|..:.|...||.|.....|       |...|.|   |.:| |....| |:.|:|
Human   125 ---DVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTV---NSNP-PARFIW-KRGSDTLSHSQD 181

  Fly   174 -GSDL--PIYIWYESYPEHIEEGYKGRVSRVSQDSPFGSASLNLTNIRESDQGWYECKVVFLNRD 235
             |.|:  |:|...|                        :..|.|.|:|..|...|.|:|...|..
Human   182 NGVDIYEPLYTQGE------------------------TKVLKLKNLRPQDYASYTCQVSVRNVC 222

  Fly   236 PKQHKNGTWFHLDVHAPPRFSVTPEDIIYVNLGDSIILNC-QADGTPTPEILWYKDANPVDPSPT 299
            ....|..|:...:..|||...::..:.:.||.|:::.:.| ...|.|.|::.|.....|:    .
Human   223 GIPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPL----P 283

  Fly   300 VGIFNDGTELRISTIRHEDIGEYTCIARNGEGQ-VSHTARVIIAG--GAVIMVPPTNQTKLE--- 358
            :|....|..|.|.:::..|.|.|.|.|.|..|. ...|..:::..  .|...:.|....:.|
Human   284 LGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKESENIQ 348

  Fly   359 -GEKVIFSCEAKAMP-GNVTVRWYREGSPVREVAALETRVTIRKD--------GSLIINPIKPDD 413
             |:.:..||...|:| ..||.:|::.|.|.|    :..|:.:.::        .||.:..:...|
Human   349 LGQDLKLSCHVDAVPQEKVTYQWFKNGKPAR----MSKRLLVTRNDPELPAVTSSLELIDLHFSD 409

  Fly   414 SGQYLCEVTNGIGDPQSASAYLSVEYP-AKVTFTPTVQYLPFRLAGVV--------QCYIKSSPQ 469
            .|.|||..:    .|.:....||||.. :..|..||:.....|....|        ||.::..|:
Human   410 YGTYLCMAS----FPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVRGKPR 470

  Fly   470 LQYVTWTK-DKR-LLEPYQMKDIVVMANGSLLFTRVNEEHQGQYAC--TPYNAQGTAGASGVMDV 530
             ..|.|:: ||. .|.|..: .:....:|.|...||:.:..|.|.|  ..||..........:.:
Human   471 -PPVLWSRVDKEAALLPSGL-PLEETPDGKLRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQL 533

  Fly   531 LVRKPPAFTVEPETLYQRK-VGDSVEMHCDALEAEGTERPTIKWQRQEGEQL---------TESQ 585
            .|:.||  .|||.:...|: :|..|.:.|..|........:..| |.:|:.|         .|:.
Human   534 NVQFPP--EVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVW-RFKGQLLPPPPVVPAAAEAP 595

  Fly   586 RNRIKISGGNITIENLRREDFGYYQCVVSNEVATLMAVTQLVIEGTQPHAPYNITGKATES---- 646
            .:      ..:.::.:.|:..|.|:|.|||:|.:...:.|:..:...|.. |..|...|.|
Human   596 DH------AELRLDAVTRDSSGSYECSVSNDVGSAACLFQVSAKAYSPEF-YFDTPNPTRSHKLS 653

  Fly   647 ---SITLQWLPGYSGGSEYKQDYTIWFREAGVNDWQTI-------SVTPSGSTQVTINGLASGTT 701
               |..|||........:...:|.:..|:  :|....:       .|......:..:..|....:
Human   654 KNYSYVLQWTQREPDAVDPVLNYRLSIRQ--LNQHNAVVKAIPVRRVEKGQLLEYILTDLRVPHS 716

  Fly   702 YEFQVVGRNVLGDG-MMSKVMTVRTLEDAPAAPRNVKAATQPPDSFFQLMPDEADLLAYF----- 760
            ||.::......|.| |.|:::..                |:|.:|     |:.:|...:|
Human   717 YEVRLTPYTTFGAGDMASRIIHY----------------TEPINS-----PNLSDNTCHFEDEKI 760

  Fly   761 -----DIYFHTD-SRGTLVYSPPKLRVKGPKPGPPRNVSVTEVSNGFLITWQSPLE---RAHIV- 815
                 |:..:.| :|...:...||   :.|..|||.::|.|.......|....|.|   ||.:|
Human   761 CGYTQDLTDNFDWTRQNALTQNPK---RSPNTGPPTDISGTPEGYYMFIETSRPRELGDRARLVS 822

  Fly   816 -------KFYTIKY 822
                   |||.:.:
Human   823 PLYNASAKFYCVSF 836

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tutl	NP_001303307.1	V-set	137..250	CDD:284989	29/128 (23%)
		IG_like	137..229	CDD:214653	25/107 (23%)
		I-set	253..341	CDD:254352	22/89 (25%)
		IGc2	268..331	CDD:197706	17/63 (27%)
		I-set	346..437	CDD:254352	23/103 (22%)
		Ig	349..437	CDD:299845	23/100 (23%)
		Ig	459..530	CDD:299845	19/82 (23%)
		IG_like	549..628	CDD:214653	18/88 (20%)
		IGc2	551..617	CDD:197706	16/74 (22%)
		FN3	633..725	CDD:238020	20/106 (19%)
		FN3	786..874	CDD:238020	14/48 (29%)
MDGA1	XP_006715119.1	IG_like	46..126	CDD:214653	14/68 (21%)
		IGc2	52..115	CDD:197706	12/46 (26%)
		IG_like	152..217	CDD:214653	22/93 (24%)
		Ig	153..217	CDD:143165	22/92 (24%)
		IG_like	248..326	CDD:214653	21/81 (26%)
		IGc2	254..315	CDD:197706	17/64 (27%)
		IGc2	350..418	CDD:197706	19/71 (27%)
		IG_like	450..535	CDD:214653	19/86 (22%)
		IGc2	455..515	CDD:197706	15/61 (25%)
		Ig	541..622	CDD:299845	20/87 (23%)
		IG_like	543..631	CDD:214653	20/94 (21%)
		MAM	753..917	CDD:279023	21/87 (24%)
		MAM	753..916	CDD:99706	21/87 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910