DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tutl and Lrit1

DIOPT Version :9

Sequence 1:	NP_001303307.1	Gene:	tutl / 46015	FlyBaseID:	FBgn0010473	Length:	1536	Species:	Drosophila melanogaster
Sequence 2:	NP_647547.2	Gene:	Lrit1 / 246214	RGDID:	628607	Length:	623	Species:	Rattus norvegicus

Alignment Length:	649	Identity:	126/649 - (19%)
Similarity:	220/649 - (33%)	Gaps:	227/649 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 PLEIPEQRASKCRGDIDRTTTTTIPASKTLTASP--------------AKTAAFTVKTTRRRRSR 84
            |..||   ...|:..::||....:|..   |..|              ::.:...::..||.|..
  Rat    54 PASIP---PDTCKLRLERTAIRRVPGE---TFRPLSRLEQLWLPYNALSELSTLMLRGLRRLREL 112

  Fly    85 RRAEGSSICVPIRRGQGSTPTPTIQVLQFVLVSLLALLAKNAQAHNIPEDAVHITAILGEGVIFN 149
            |......:..|   ......||.:|:|.         |..| :...:|.:|||..    |.:.|
  Rat   113 RLPGNHLVTFP---WAALKDTPQLQLLD---------LQAN-RLSTLPPEAVHFL----ENLTF- 159

  Fly   150 CHVEFPNDHPVPYVLQWDKKVSETGSDLPIYIWYESYPEHIEEG--YKGRVSRV---SQDSPFGS 209
              ::..|:.    :::..:::.:|        |     .|::.|  ...|.:|:   .||:|: .
  Rat   160 --LDLSNNQ----LMRLPEELLDT--------W-----AHLKTGPYLSSRRTRLVLGLQDNPW-V 204

  Fly   210 ASLNLTNIRESDQGWYECKVVFLNR-----DPKQHKNGTWFHLDVHAPPRFSVTPE-----DIIY 264
            ....|.::.....|| ...::|:..     .|:......:..|::    |...:||     ..|.
  Rat   205 CDCRLYDLVHLLDGW-ASNLIFIEARLRCGSPRSLAGVAFSQLEL----RKCQSPELRPGVTSII 264

  Fly   265 VNLGDSIILNCQADGTPTPEILWYK-DANPVDPSPTVGIFNDG---TELRISTIRHEDIGEYTCI 325
            ..||.:::|.|.|.|.|.||:.|.: :..|::.:....:.:||   |.|.:..:...|.|:|.|.
  Rat   265 SPLGSTVLLRCGATGIPGPEMSWRRANGRPLNGTVHQEVSSDGSSWTLLDLPVVSLFDSGDYICQ 329

  Fly   326 ARNGEGQVSHTARVIIAGGAVIMVPPTNQTKLEGEKVIFSCEAKAMPGNVTVRWYREGSPVREVA 390
            |:|..|    .:..:|   ::|:..|...|:..|           :||.:   |.|.|... |.|
  Rat   330 AKNFLG----ASETLI---SLIVTEPQTSTEYTG-----------IPGAL---WARTGEGA-EAA 372

  Fly   391 ALETRVTIRKDGSLIINPIKPDDSGQYLCEVTNGIGDPQSASAYLSVEYPAKVTFTPTVQYLPFR 455
            |...::..|.      .|..|:                           |..:...|:|
  Rat   373 AYNNKLVARH------VPHVPE---------------------------PVALATKPSV------ 398

  Fly   456 LAGVVQCYIKSSPQLQYVTWTKDKRLLEPYQMKDIVVMANGSLLFTRVNEEHQGQYACTPYNAQG 520
                        |.:      |::..|:.:|| |:    .|.  |:|...|||
  Rat   399 ------------PSI------KEELPLQNFQM-DV----PGE--FSREPSEHQ------------ 426

  Fly   521 TAGASGVMDVLVRKPPAFTVEPETLYQRK---VGD---SVEMHCDALEAEGTERPTIKW----QR 575
                                  ||...|.   |||   ||.:...|.:|..|...::.:    ||
  Rat   427 ----------------------ETQMVRSLKVVGDTYHSVSLVWKAPQAGNTTAFSVLYAVFGQR 469

  Fly   576 QEGEQLTESQRNRIKISGGNITIENLRREDFGYYQCVV------SNEVATLMAVTQLV-IEGTQ 632
                   :.:|..::....::|||.|..:. .|..||.      :.|...:.:..::| .||||
  Rat   470 -------DMRRMTVEAGKTSVTIEGLAPKT-KYVACVCVRGLVPTKEQCVIFSTDEVVDAEGTQ 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tutl	NP_001303307.1	V-set	137..250	CDD:284989	19/122 (16%)
		IG_like	137..229	CDD:214653	16/96 (17%)
		I-set	253..341	CDD:254352	26/96 (27%)
		IGc2	268..331	CDD:197706	20/66 (30%)
		I-set	346..437	CDD:254352	15/90 (17%)
		Ig	349..437	CDD:299845	14/87 (16%)
		Ig	459..530	CDD:299845	12/70 (17%)
		IG_like	549..628	CDD:214653	20/95 (21%)
		IGc2	551..617	CDD:197706	17/78 (22%)
		FN3	633..725	CDD:238020	126/649 (19%)
		FN3	786..874	CDD:238020
Lrit1	NP_647547.2	LRRNT	23..61	CDD:214470	3/9 (33%)
		LRR 1	60..81		5/23 (22%)
		LRR_8	63..143	CDD:290566	16/95 (17%)
		leucine-rich repeat	64..84	CDD:275378	5/22 (23%)
		LRR 2	84..105		0/20 (0%)
		leucine-rich repeat	85..132	CDD:275378	6/49 (12%)
		LRR 3	108..128		4/22 (18%)
		LRR_8	131..>176	CDD:290566	12/65 (18%)
		LRR_4	131..172	CDD:289563	12/61 (20%)
		LRR 4	132..153		7/30 (23%)
		leucine-rich repeat	133..156	CDD:275378	8/36 (22%)
		LRR 5	156..177		2/27 (7%)
		leucine-rich repeat	157..180	CDD:275378	4/42 (10%)
		leucine-rich repeat	181..205	CDD:275378	6/24 (25%)
		TPKR_C2	201..>240	CDD:301599	6/40 (15%)
		Ig	257..345	CDD:299845	24/94 (26%)
		IG_like	267..345	CDD:214653	23/84 (27%)
		FN3	431..501	CDD:214495	19/77 (25%)
		LRR 6	525..548		1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900