DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tutl and Ptprq

DIOPT Version :9

Sequence 1:	NP_001303307.1	Gene:	tutl / 46015	FlyBaseID:	FBgn0010473	Length:	1536	Species:	Drosophila melanogaster
Sequence 2:	NP_001357916.1	Gene:	Ptprq / 237523	MGIID:	1096349	Length:	2301	Species:	Mus musculus

Alignment Length:	1629	Identity:	319/1629 - (19%)
Similarity:	523/1629 - (32%)	Gaps:	533/1629 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 EIPEQRASKCRGDIDRTTTTTIPASKTLT-ASPAKTAAFTVKTTRRRRSRRRAEGSSICVPIRRG 99
            ::||     |..:.|....:|...|.||: |:|      .::||....:..|.:.||:..
Mouse   216 KLPE-----CNENSDSFLWSTTSPSPTLSRATP------PLRTTHLSNTLARNKISSVWK----- 264

  Fly   100 QGSTPTPTIQVLQFVLVS-------LLALLAKNAQAHNIPEDAVHITAILGEGVIFNCHVEFPND 157
                     :.:.||:..       |..:.|...:|..|....|.....:.||...||..  .|.
Mouse   265 ---------EPISFVVTHLRPYTTYLFEVSAVTTEAGYIDSTIVRTPESVPEGPPQNCIT--GNV 318

  Fly   158 HPVPYVLQWDKKVSETG---------------------------SDLPIYIWYESYPEHIEEGYK 195
            ....:.:.||.....||                           :.|..:..|:.|.........
Mouse   319 TGKAFSISWDPPAIVTGKFSYRVELYGPTGRILDNSTKDLRFVFTHLTPFTMYDVYVAAETSAGV 383

  Fly   196 GRVSRVS----QDSPFGSASLNL-----TNIRESDQGWYECKVVFLNRDPKQHKNGTWFHLDVHA 251
            |..|.:|    .|.|.....|.:     |.||.|   |         |.|:| .||......|
Mouse   384 GPKSNLSVFTPPDVPGAVFDLQIVEVEATEIRVS---W---------RKPRQ-PNGIISQYRV-- 433

  Fly   252 PPRFSVTPEDIIYVN---LGDSIILNCQADGTPTPEILWYKDANPVDPSPTVGIFNDGTELRI-- 311
              :.||....:|..|   .|....:|    ...||||:     |.||  |.:|.:....|:..
Mouse   434 --KVSVLESGVILENTLLTGQDEYIN----NPMTPEIM-----NLVD--PMIGFYEGSGEMSSDL 485

  Fly   312 ----------------STIRHEDIGEYTCIARNGEGQ----VSHTARVIIAGGAVIMVPPTNQTK 356
                            :..|.||......:|...:..    ..|.:.||..     :||.|..|
Mouse   486 HSLASFIYNSHPHDFPARTRVEDQRSPVVVATRNQYMTDIAAEHLSYVIRR-----LVPFTEHT- 544

  Fly   357 LEGEKVIFSCEAKAMPGNVTVRWYREGSPVREVAALETRVTIRKDGSLIINPIKPDDSGQYLCEV 421
                   .|..|..:.|        ||.|.  |..:.||..:  ..|:.|...|...|...|.
Mouse   545 -------ISVSAFTVMG--------EGPPT--VLTVRTREQV--PSSIQIINYKNISSSSILL-- 588

  Fly   422 TNGIGDPQSASAYLSVEYP-AKVTFTPTVQYLPFRLAGVVQCYIKSSPQLQYVTWTKDKRLLEPY 485
               ..||.        ||| .|:|                          .|..:..:......:
Mouse   589 ---YWDPP--------EYPNGKIT--------------------------HYTIYAMELDTNRAF 616

  Fly   486 QMKDIVVMANGSLLFTRVNEEHQGQYACTPYNAQGTAGASGVMDVLVRKPPAFTVEPETLYQR-K 549
            ||..:    :.|.|.|.:.:..:.:.........|.:..|...|:.||.|..   |||:..|. |
Mouse   617 QMTTV----DNSFLITGLKKYTRYKMRVAASTHVGESSLSEENDLFVRTPED---EPESSPQDVK 674

  Fly   550 VGDSVEMHCDALEAEGTERPT-------IKWQRQEGEQLTESQRNRIKISG------GNITIENL 601
            |.| |.....:|.....|:|.       :.:|..:...:..:....|.:|.      .||:|::.
Mouse   675 VTD-VSPSELSLTWSPPEKPNGIIIAYEVFYQNADALFVKNTSTTNITLSDLKPYTLYNISIQSY 738

  Fly   602 RREDFGYYQCVVSNEVATLMAVTQLVIEGTQPHAPYNITGKATES-SITLQWLPGYSGGSEYKQD 665
            .|...|       |:.::|::|.  ..|.....||.|||.|...| .|.:.:||..|... ..|.
Mouse   739 TRLGHG-------NQSSSLLSVR--TSETVPDSAPENITYKNISSEEIEIFFLPPRSPNG-IIQK 793

  Fly   666 YTIWFREAGVNDWQTISVTPSGSTQVTINGLASGTTYEFQVVGRNVLGDGMMSKVMTVRTLEDAP 730
            |||:.:.:..::.:||..|   |..:||.||...|.|..:|....:.|:|:.|..:::.|.||||
Mouse   794 YTIYLKRSNSHEARTIETT---SLTLTIGGLKKYTHYVIEVSASTLKGEGVRSMPISILTEEDAP 855

  Fly   731 -AAPRN----------VKAATQPPDSFFQLMPDEADLLAYFDIY--------------------- 763
             :.|:|          |..:.|||     |.|:  .::.|:.:|
Mouse   856 DSPPQNFSVKQLSGVTVMLSWQPP-----LEPN--GIILYYTVYVWDKVSLKTINATEVSLELSD 913

  Fly   764 --FHTD---------------SRGTLV-YSPPKLRVKGPKPGPPRNVSVTEVSNGFLIT-WQSPL 809
              :|.|               :|.::: :..|    :|....||::|....:|:..:|. |..|:
Mouse   914 LDYHADYSAYVTASTRFGDGKTRSSVINFRTP----EGEPSDPPKDVHYVNLSSSSIILFWTPPV 974

  Fly   810 ERAHIVKFYTIKYRTDAQWKTLNRGQIRPEETQYLVKNLVGGRTYYFRVLANSEKSYESSDEVKF 874
            :...|:::|::.|:..:  .|..:.....|.||......|..|.|...|.     ||.:
Mouse   975 KPNGIIQYYSVYYQNTS--STFVQNFTLLEVTQEPGNVTVSARIYKLAVF-----SYYT------ 1026

  Fly   875 PVPARVKHKAITAGVVGGILFFIVAIILSVCAVKICNKRKRRKQEKEFNMVACRITDARNIAANN 939
                                |::.|..|      :.|..|                       ::
Mouse  1027 --------------------FWLTASTL------VGNGNK-----------------------SS 1042

  Fly   940 HHLHNRSTGSISSGQVPLKKYKQTRISSLTAILIAILHWIW-PPDRCTNCHSIYSSPNLEDGDED 1003
            ..:|..:...|..|.|....|:..   |.|||.::     | ||.:.......|.|.||:.....
Mouse  1043 DVIHVYTDQDIPEGGVGNLTYESL---SSTAINVS-----WTPPSQPNGLVFYYVSLNLQQSPPR 1099

  Fly  1004 DGGGGRRRSVSRIQRSL--DG-----RFVLDVEGVSKLGYSQQTLESGNV----DVVDGGLFERR 1057
            .    ||..::..:.|:  |.     .::..:...::.|:|:......::    ||.|.......
Mouse  1100 H----RRPPLTTYENSIYFDNLEKYTDYIFKITPSTEKGFSETYTAQLHIKTEEDVPDTPPIINT 1160

  Fly  1058 NSNVSQKS---SSD-----DGGFLS----------RRNFITARASWRRPLVASSSQLSLQSAADS 1104
            ..|:|..|   |.|     :|..||          .|.|:|   |....::...|..:|.|...:
Mouse  1161 FKNLSSTSILLSWDPPLKPNGAILSYHLTLQGTHANRTFVT---SGNHIVLEELSPFTLYSFLAA 1222

  Fly  1105 ARGFLQGLLKIGAKQSAVPPNSQSYF--DEAVSGARYQNV-LRPYTSS----------------- 1149
            || .::||          .|:|..:|  ||:...|..||: |..|||.
Mouse  1223 AR-TMKGL----------GPSSILFFYTDESAPLAPPQNLTLINYTSDFVWLTWSPSPLPGGIVK 1276

  Fly  1150 ----------------NNLYG---NADRSRPLHINTISGSLSQQQQLYTPSRISRIFSSSPQQLQ 1195
                            .|:.|   :|..:....::|.|.|:|...::...::.|.:...:.|:..
Mouse  1277 VYSFKIHEHETDTVFYKNISGFQTDAKLAGLEPVSTYSISVSAFTKVGNGNQFSNVVKFTTQESV 1341

  Fly  1196 PHHQQLLLSSGGSGAYPTHFSDLSTVY-PPNSA-----------ERSSHNLSSR---YRY----- 1240
            |...|.:      ......:..:|.:: ||..|           |.:|..:|.|   |.:
Mouse  1342 PDAVQNI------ACVARDWQSVSVMWDPPRKANGIIIHYMITVEGNSTKVSPRDPMYTFTKLLA 1400

  Fly  1241 ---YSQELPSLRTIQEETRRQQQQKQHP--------------LEDHFVPLQLPSPPSWRSYYQSQ 1288
               |..|:.:..:..|....|......|              ::...|.|:...|.:...|:|
Mouse  1401 NTSYIFEVRASTSAGEGNESQCNVSTLPETVPSVPTNTAFSNVQSTSVTLRWIKPDTILGYFQ-- 1463

  Fly  1289 ASYRPRTR--------WYPRHHSRLFSNRQQQHEMLSPLPQLNLNLRNSMNPGGLEASPESR--- 1342
             :|:..|:        |.|        ....:|:.:..|.:.|   :......||:.....|
Mouse  1464 -NYKITTQLRAQKCREWEP--------EECVEHQEVQYLYEAN---QTEDTVRGLKKFQWYRFQV 1516

  Fly  1343 --SSSSGFGSKNTSNHPGSTSEWRLLPPYRAPP-SPPKHSGYFGGQQAQGQTPHG---SYSYPRA 1401
              |:::|:         |:.|.|........|| .||::      .:....:|.|   |::.|..
Mouse  1517 AASTNAGY---------GNASSWISTQTLPGPPDGPPEN------VRVVATSPFGINISWNEPAI 1566

  Fly  1402 TTPP 1405
            .|.|
Mouse  1567 ITGP 1570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tutl	NP_001303307.1	V-set	137..250	CDD:284989	28/148 (19%)
		IG_like	137..229	CDD:214653	23/127 (18%)
		I-set	253..341	CDD:254352	22/112 (20%)
		IGc2	268..331	CDD:197706	16/80 (20%)
		I-set	346..437	CDD:254352	20/90 (22%)
		Ig	349..437	CDD:299845	20/87 (23%)
		Ig	459..530	CDD:299845	8/70 (11%)
		IG_like	549..628	CDD:214653	18/91 (20%)
		IGc2	551..617	CDD:197706	14/78 (18%)
		FN3	633..725	CDD:238020	29/92 (32%)
		FN3	786..874	CDD:238020	20/88 (23%)
Ptprq	NP_001357916.1	FN3	57..151	CDD:238020
		FN3	308..393	CDD:238020	14/86 (16%)
		fn3	399..>441	CDD:365830	14/58 (24%)
		FN3	570..654	CDD:238020	20/126 (16%)
		fn3	668..744	CDD:365830	15/76 (20%)
		FN3	762..850	CDD:238020	29/91 (32%)
		fn3	857..934	CDD:365830	12/83 (14%)
		FN3	951..1049	CDD:238020	26/159 (16%)
		FN3	1056..1137	CDD:238020	19/92 (21%)
		FN3	1152..1233	CDD:238020	21/94 (22%)
		FN3	1247..1337	CDD:238020	14/89 (16%)
		FN3	1342..1421	CDD:238020	14/84 (17%)
		FN3	1432..1535	CDD:238020	20/125 (16%)
		FN3	1542..1638	CDD:238020	8/35 (23%)
		FN3	1645..1734	CDD:238020
		UP_III_II	1759..1928	CDD:297589
		R-PTPc-Q	2033..2256	CDD:350464
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900