DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tutl and ncam-1

DIOPT Version :9

Sequence 1:	NP_001303307.1	Gene:	tutl / 46015	FlyBaseID:	FBgn0010473	Length:	1536	Species:	Drosophila melanogaster
Sequence 2:	NP_741709.1	Gene:	ncam-1 / 180418	WormBaseID:	WBGene00017184	Length:	955	Species:	Caenorhabditis elegans

Alignment Length:	1001	Identity:	199/1001 - (19%)
Similarity:	326/1001 - (32%)	Gaps:	259/1001 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 TLTASPAKTAAFTVKTTRRRRSRRRAEGSSICVPIRRGQGSTPTPTIQ-------VLQFVLVSLL 119
            ||:.||         |..|.::||..:...:...::...|:.....|:       :.:|.....:
Worm    48 TLSLSP---------TEERLQNRRSGDNFLVVCKVKDFDGAASDAKIEWYRDGKLIPRFGSTMTI 103

  Fly   120 ALLAKNAQAHNIPEDAVHITAILGEGVIFNCHVEFPNDHPVPYVLQWDKKVSETGS--DLPIYIW 182
            .....|....|.|:        :.:|..:.|..|...:         .::||...|  |.|.::.
Worm   104 ERTYSNQLMINRPK--------ISDGGKYTCKTEIQGE---------QQEVSAEISFVDPPKFLN 151

  Fly   183 YESYPEHIEEGYKGRV-------SRVSQDSPFGSASLNLTNIR------------------ESDQ 222
            .:. .:|.|||.:..:       .::.....|...:|:.|:.|                  :.|.
Worm   152 VQE-SQHPEEGTRAEIVCEVEGTDQLEVFWQFNGVTLDETSQRGYEFSENNQILYIPHFTAKKDD 215

  Fly   223 GWYECKVVFLNRDPKQHKNGTWFHLDVHAPPRFSVTPEDIIYVNL---GDSIILNCQADGTPTPE 284
            |.|.|...       |:.:.....::|....|.::|..|:...|.   |.:|.|.|.|.|.|.|.
Worm   216 GIYNCNAA-------QYSSFETLSVNVTGYARPTITVFDVPNGNRGIEGHTIELKCGAVGKPKPT 273

  Fly   285 ILWY--KDANPVDPSPTVGIFNDGTELRISTIRHEDIGEYTCIARNGEGQVSHTARVIIAGGAVI 347
            ..|:  .|..|:..|....: .:|. |.|.::..||.|.|.|:|.|..|....|..:     ||.
Worm   274 YKWFFEDDEVPIARSDKHNV-EEGL-LIIESLNSEDAGTYKCVANNTVGSNERTFDL-----AVF 331

  Fly   348 MVPPTN----QTKLEGEKVIFSCEAKAMPGNVTVRWYREGSPVREVAALETRVTIRKDGSLIIN- 407
            :.|..:    ....||:.|...|.           ::.||....:..:..:...:|.:.....|
Worm   332 LKPKVDLKHEYVVKEGDDVELVCS-----------YHGEGHVTAKFVSGHSEFAVRNEAVSAGNS 385

  Fly   408 -PIKPDDSGQYLCEVTNGIGDPQSASAYLSVEYPAKVTFTPTVQYLPFRLAGVVQCYIKSSPQLQ 471
             .|:|:.:...  |||....:.:..|....||..:.........:...:..|      :...|.:
Worm   386 EEIRPESNESE--EVTTTSENSEETSTQDEVELKSAENVNDEEDHTSQQDDG------EQDEQEE 442

  Fly   472 YVTWTKDKRLLEPYQMKDIVVMANGSLLFTRVNE---EHQGQYACTPYNAQGTAGASGVMDVLVR 533
            ...|   ||..:....:.|.|.|..:.|...:..   |....|.|...|..||  .:.|..|.:.
Worm   443 SKKW---KRFADDVNNQRISVRAEENKLILTIKSISLEDAADYTCAVSNDAGT--VNKVTQVGII 502

  Fly   534 KPPAFTVEPETLYQRKVGDSVEMHCDALEAEGTERPTIKWQRQEGEQLTESQRNRIKI----SGG 594
            .||..........:...|::|.::||.     :..|:.||...:..:..|:....|:|    |..
Worm   503 HPPTLRHYTGPHIRSFDGNTVSVYCDV-----SAVPSPKWHWFKNGKEVEANGVSIQIFTQGSST 562

  Fly   595 NITIENLRRED-FGYYQCVVSNEVATLMAVTQLVIEGTQPHAP---------YNITGKAT-ESSI 648
            .:|:||....| ||.|.|...|.|..|..... ||:...|..|         |...||.: ||.|
Worm   563 KLTLENFDGSDNFGVYTCRADNGVGQLEKQID-VIKVVSPATPSGMNCKKMVYPNYGKCSFESDI 626

  Fly   649 ---------TLQWLPGYSGGSEYKQDYTIWFREAGVNDW---QTISVTPSGSTQVTINGLASGTT 701
                     |::.|  .:...|.:.||          :|   |.:||  .....:||..|.|.|.
Worm   627 YEKEESKPQTMELL--VAKLEEMESDY----------NWSHAQPVSV--PFEDDLTIPNLTSNTQ 677

  Fly   702 YEFQVVGRNVLGDGMMSKVMTVRTLED-APAAPRNV--------KAATQPPDSFFQLMPDEADLL 757
            |..:....|..|....|:.:::.|.:. ||.||.:|        ..:...|:       |....|
Worm   678 YVIKARAVNEAGSSEYSEEISLETTDPWAPQAPGSVAMKCSDYCTVSWDTPN-------DHGSPL 735

  Fly   758 AYFDIYFHTDSRGTLVYSPPKLRVKGPKPGPPRNVS------------VTEVSNGFLITWQSPLE 810
            ..|.:...     .:.|......|:........|.|            .||.||
Worm   736 LKFKVTIQ-----EMKYKTDDDEVEEKSDEKSNNNSEETETTTSDDNDETEASN----------- 784

  Fly   811 RAHIVKFYTIKYRTDAQWKTL-----------------NRGQIRP-----------EETQYLVKN 847
                 :...||..::.|..||                 .|.::.|           ||.|..:.|
Worm   785 -----ESIEIKENSEEQETTLAHEDSAEILPTDPSTSVERDEMVPYGSLLVLNVDSEENQVQLTN 844

  Fly   848 LVGGRTYYFRVLANSEKSYESSDEVKFPV---PARVK------HKAITAGVVGGILFFIVAI--- 900
            :.....|...|.|.:||......|:.|..   |.:.:      |..|...:  |:||.::.:
Worm   845 IKQHSYYKISVAAENEKGQGEPAEIDFQTDDSPTKYEEGIDSTHLIIAIAI--GVLFLLLLVDLG 907

  Fly   901 --------ILSVCAVKICNKRKRRKQ 918
                    ::|...:.:|.|....||
Worm   908 CFITNKCGLISCICLNLCGKNAGAKQ 933

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tutl	NP_001303307.1	V-set	137..250	CDD:284989	21/139 (15%)
		IG_like	137..229	CDD:214653	20/118 (17%)
		I-set	253..341	CDD:254352	28/92 (30%)
		IGc2	268..331	CDD:197706	22/64 (34%)
		I-set	346..437	CDD:254352	16/96 (17%)
		Ig	349..437	CDD:299845	15/93 (16%)
		Ig	459..530	CDD:299845	15/73 (21%)
		IG_like	549..628	CDD:214653	22/83 (27%)
		IGc2	551..617	CDD:197706	20/70 (29%)
		FN3	633..725	CDD:238020	26/113 (23%)
		FN3	786..874	CDD:238020	23/127 (18%)
ncam-1	NP_741709.1	IG	64..142	CDD:214652	11/94 (12%)
		Ig	69..140	CDD:143165	11/87 (13%)
		IG_like	153..236	CDD:214653	13/90 (14%)
		Ig	160..222	CDD:299845	10/61 (16%)
		IG_like	256..330	CDD:214653	24/80 (30%)
		IGc2	256..320	CDD:197706	22/65 (34%)
		IG_like	<445..499	CDD:214653	14/58 (24%)
		Ig	<445..498	CDD:143165	14/57 (25%)
		IG_like	520..596	CDD:214653	22/81 (27%)
		IGc2	520..587	CDD:197706	20/71 (28%)
		FN3	<652..701	CDD:238020	13/50 (26%)
		FN3	<817..873	CDD:238020	13/55 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10075
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100