DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment tutl and Dscam

DIOPT Version :9

Sequence 1:NP_001303307.1 Gene:tutl / 46015 FlyBaseID:FBgn0010473 Length:1536 Species:Drosophila melanogaster
Sequence 2:XP_038943864.1 Gene:Dscam / 171119 RGDID:619992 Length:2034 Species:Rattus norvegicus


Alignment Length:1604 Identity:347/1604 - (21%)
Similarity:553/1604 - (34%) Gaps:424/1604 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   137 HITAILGEGVIFNCHV-EFPNDHPVPYVLQWDKKVSETGSDLPIYIWYESYPEHIEEGYKGRVSR 200
            :||||.|.....:|.| .:|.     |.::|.|..:.    ||.        .|.:..::     
  Rat   512 NITAIAGRDTYIHCRVIGYPY-----YSIKWYKNANL----LPF--------NHRQVAFE----- 554

  Fly   201 VSQDSPFGSASLNLTNI-RESDQGWYECKVVFLNRDPKQHKNGTWFHLDVHAPPRFSVTPEDIIY 264
                   .:.:|.|::: :|.|:|.|.|.|:.    ..|.......|:.|..||  .:.|.:...
  Rat   555 -------NNGTLKLSDVQKEVDEGEYTCNVLV----QPQLSTSQSVHVTVKVPP--FIQPFEFPR 606

  Fly   265 VNLGDSIILNCQADGTPTP-EILWYKDANPVDPSPTVGIFN-DGT-ELRISTIRHEDIGEYTCIA 326
            .::|..:.:.|.......| .|.|.||..|:..|..|.|.| |.| .||||.:.....|.|||||
  Rat   607 FSIGQRVFIPCVVVSGDLPITITWQKDGRPIPASLGVTIDNIDFTSSLRISNLSLMHNGNYTCIA 671

  Fly   327 RNGEGQVSHTARVIIAGGAVIMVPPTNQTKLEGEKVIFSCEAKAMPGNVTVRWYREGS--PVREV 389
            ||....|.|.:::|:......:|.|.:|..:.|:.||.:|.|:..|....|..:.:|:  |..:.
  Rat   672 RNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQP 736

  Fly   390 AALETRVTIRKDGSLIINPIKPDDSGQYLCEVTNGIGDPQSASAYLSVEYPAKVTFTPTVQYLPF 454
            .||..|:.:..:|||:|..:..:|||.|||:|:|.:|...|.|.||:|:.||.:|..|.......
  Rat   737 IALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQ 801

  Fly   455 RLAGVVQCYIKSSPQLQYVTWTKDKRLLEPYQMKDIV--------VMANGSLLFTRVNEEHQGQY 511
            .....:.|.......: .|.|.|:.|::.|...:.:|        |::...:|.| |.|: .|.:
  Rat   802 GQRKEMSCTAHGEKPI-IVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPT-VRED-SGFF 863

  Fly   512 ACTPYNAQGTAGASGVMDVLVRKPPAFTVEPETLYQRKVGDSVEMHCDALEAEGTERPTIKWQ-- 574
            :|...|:.|.  ..|::.:.|::||               |..|:....::|...   |::|.  
  Rat   864 SCHAINSYGE--DRGIIQLTVQEPP---------------DPPEIEIKDVKARTI---TLRWTMG 908

  Fly   575 --------------RQEGEQLTESQRNR-IKISGGNITIENLRREDFGYYQCVVSNEVATLMAVT 624
                          :.:.:....:||.: :.....:.||.::........:....|.:.......
  Rat   909 FDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSN 973

  Fly   625 QLVI---EGTQPHAPYNITGKATES-SITLQWLPGYSGGSEYKQD-----YTIWFRE---AGVND 677
            ::.|   |......|..:..:.|.| ||.:.|    ....::.|:     |.|.:||   .|...
  Rat   974 EITITADEAAPDGPPQEVHLEPTSSQSIRVTW----KAPKKHLQNGIIRGYQIGYREYSTGGNFQ 1034

  Fly   678 WQTISVTPSGSTQV-TINGLASGTTYEFQVVGRNVLGDGMMSKVMTVRTLEDAPA-APRNVKAAT 740
            :..||:..:|.::| |::.|...|.|...|...|..|.|..|:.:...||||.|: .|.||:|..
  Rat  1035 FNIISIDTTGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIA 1099

  Fly   741 QPPDSF---FQLMPDEA---DLLAYFDIYFHTDSRGTL------VYSPPKL-------------- 779
            ..|:|.   :..:..||   .|..:..||:.....|.|      ..:.|.|              
  Rat  1100 TSPESISISWSTLSKEALNGILQGFRVIYWANLIDGELGEIKNVTTTQPSLELDGLEKYTNYSIQ 1164

  Fly   780 ------------------RVKGPKPGPPRNVSVTEVSNGFL-ITWQSPLERAHIVKFYTI----K 821
                              |.|...||||..|.....|...: ::|..||:...|::.||:    .
  Rat  1165 VLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSWLPPLKLNGIIRKYTVFCSHP 1229

  Fly   822 YRTDAQWKTLNRGQIRPEETQYLVKNLVGGRTYYFRVLANSEKSYESSDEVKFPVP-ARVKHKAI 885
            |.|     .::..:..|:...|.:.||...|.|...|:|.:.....:|.|:....| |:...:.:
  Rat  1230 YPT-----VISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARIL 1289

  Fly   886 T-AGVVGGILFFIVAIILSVCAVKICNKRKRRKQEKEFNMVACRIT-DARNIAANNHHLHNRSTG 948
            | :|.|  ...::..|:|...||.  :.....|..|:.|.....:| |.|....:|.....|:..
  Rat  1290 TFSGTV--TTPWMKDIVLPCKAVG--DPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFVIRTVK 1350

  Fly   949 SISSGQ---VPLKKYKQTRISSLTAILIAILHWIWPPD--RCTNCHSIYSSPNLEDGDEDDGGGG 1008
            :..||.   |....:....|       |..|....|||  |.|...:..||..|.....|:||..
  Rat  1351 AEDSGYYSCVANNNWGSDEI-------ILNLQVQVPPDQPRLTVSKTTSSSITLSWLPGDNGGSS 1408

  Fly  1009 RRRSVSRIQRSLD-----GRFVLDVEGVSKLGYSQQTLESGN----VDVVDGGLFERRNSNVSQK 1064
            .|..:  :|.|.|     |.|.:   ..|:..|..:.|:.|.    ......|:...|.|.:   
  Rat  1409 IRGYI--LQYSEDNSEQWGSFPI---SPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEI--- 1465

  Fly  1065 SSSDDGGFLSRRNFITARASWRRPLVASSSQLSLQSAADSARGFLQGLLKIGAKQSAVPPNSQSY 1129
                          |.|:...:.|..:...:|.........|     |..||......|..|   
  Rat  1466 --------------IEAKTLGKEPQFSKEQELFASINTTRVR-----LNLIGWNDGGCPITS--- 1508

  Fly  1130 FDEAVSGARYQNVLRPYTSSNNLYGNADRSRPLHINTISGSLSQQQQLYTPSRISRIFSSSPQQL 1194
                     :....||:  ...::..|.|:          |||:...||              .|
  Rat  1509 ---------FTLEYRPF--GTTVWTTAQRT----------SLSKSYILY--------------DL 1538

  Fly  1195 QP----HHQQLLLSSGGSGAYPTHFSDL----STVYPP--NSAERSSHNLSSRYRYYSQELPSLR 1249
            |.    ..|..:.:|.|......:|:.|    ||: ||  .|..:|...|::     ::.|..|.
  Rat  1539 QEATWYELQMRVCNSAGCAEKQANFATLNYDGSTI-PPLIKSVVQSEEGLTT-----NEGLKILV 1597

  Fly  1250 TIQ--------------EETRRQQQQKQHPLEDHFVPLQLPSPPSWRSYYQSQASYRPRTRWYPR 1300
            ||.              ...||:::|:...|.|.            :|..:...|...||     
  Rat  1598 TISCILVGVLLLFVLLLVVRRRRREQRLKRLRDA------------KSLAEMLMSKNTRT----- 1645

  Fly  1301 HHSRLFSNRQQQHEMLSPLP--QLNLNLRNSM--------------------------------- 1330
              |...|.:||...|...:|  ||.:..|::|                                 
  Rat  1646 --SDTLSKQQQTLRMHIDIPRAQLLIEERDTMETIDDRSTVLLTDADFGEAAKQKSLTVTHTVHY 1708

  Fly  1331 ----------------NPG-------GLEASPESRSSSSGFGSKNTSNHPGS-------TSEWRL 1365
                            .||       ..:|.|.:|:.   :.|:.|.|.|..       |::|| 
  Rat  1709 QSVSQATGPLVDVSDARPGTNPTTRRNAKAGPTARNR---YASQWTLNRPHPTISAHTLTTDWR- 1769

  Fly  1366 LPPYRAPPSPPKHSGYFGGQQAQG---------QTPHGSYSYPRATT-------------PPYTM 1408
            ||..||..|..|.|..:....:|.         .|...|.:|.....             ..:|:
  Rat  1770 LPTPRATGSVDKESDSYSVSPSQDTDRARSSMVSTESASSTYEELARAYEHAKMEEQLRHAKFTI 1834

  Fly  1409 AHWL-------EMISRLNAATDSNLPKAPCPVDVGSVDGHYEFDPATPTPSASSMLREDLNLHID 1466
            ....       ::.:..|..|||.....|      |..|...|..:.|.|.....:   :|:.:.
  Rat  1835 TECFISDTSSEQLTAGTNEYTDSLTSSTP------SESGICRFTASPPKPQDGGRV---VNMAVP 1890

  Fly  1467 THPYHHHTLGPLSGSLLH--SHAPYGGGARKQRSLP--AHLPRY 1506
              ..|...|...|....|  :|.|.       |:|.  .|||.|
  Rat  1891 --KAHRPVLETRSSKSRHQLTHVPL-------RALGDLIHLPPY 1925

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tutlNP_001303307.1 V-set 137..250 CDD:284989 24/114 (21%)
IG_like 137..229 CDD:214653 21/93 (23%)
I-set 253..341 CDD:254352 30/90 (33%)
IGc2 268..331 CDD:197706 26/65 (40%)
I-set 346..437 CDD:254352 32/92 (35%)
Ig 349..437 CDD:299845 32/89 (36%)
Ig 459..530 CDD:299845 17/78 (22%)
IG_like 549..628 CDD:214653 10/95 (11%)
IGc2 551..617 CDD:197706 10/82 (12%)
FN3 633..725 CDD:238020 25/101 (25%)
FN3 786..874 CDD:238020 24/92 (26%)
DscamXP_038943864.1 Ig 26..121 CDD:416386
Ig strand A' 33..37 CDD:409353
Ig strand B 40..49 CDD:409353
Ig strand C 55..61 CDD:409353
Ig strand C' 63..66 CDD:409353
Ig strand D 72..75 CDD:409353
Ig strand E 80..85 CDD:409353
Ig strand F 98..106 CDD:409353
Ig strand G 109..121 CDD:409353
Ig 125..210 CDD:416386
Ig strand A 126..130 CDD:409353
Ig strand A' 132..136 CDD:409353
Ig strand B 139..149 CDD:409353
Ig strand C 157..163 CDD:409353
Ig strand C' 164..167 CDD:409353
Ig strand E 179..185 CDD:409353
Ig strand F 191..201 CDD:409353
IGc2 239..300 CDD:197706
Ig strand B 242..246 CDD:409353
Ig strand C 255..259 CDD:409353
Ig strand F 290..295 CDD:409353
Ig 313..395 CDD:416386
Ig strand A 314..319 CDD:409353
Ig strand A' 322..326 CDD:409353
Ig strand B 329..339 CDD:409353
Ig strand C 344..350 CDD:409353
Ig strand C' 351..354 CDD:409353
Ig strand E 368..374 CDD:409353
Ig strand F 381..389 CDD:409353
Ig 406..501 CDD:416386
Ig strand A 406..409 CDD:409353
Ig strand A' 415..419 CDD:409353
Ig strand B 422..431 CDD:409353
Ig strand C 436..442 CDD:409353
Ig strand C' 444..447 CDD:409353
Ig strand D 452..460 CDD:409353
Ig strand E 464..473 CDD:409353
Ig strand F 480..488 CDD:409353
Ig strand G 491..501 CDD:409353
Ig 504..593 CDD:416386 24/113 (21%)
Ig strand A 505..507 CDD:409353
Ig strand A' 512..516 CDD:409353 2/3 (67%)
Ig strand B 519..526 CDD:409353 0/6 (0%)
Ig strand C 533..539 CDD:409353 2/5 (40%)
Ig strand C' 540..542 CDD:409353 0/1 (0%)
Ig strand D 549..553 CDD:409353 0/3 (0%)
Ig strand E 557..563 CDD:409353 2/5 (40%)
Ig strand F 571..579 CDD:409353 4/7 (57%)
Ig strand G 583..593 CDD:409353 1/9 (11%)
Ig 596..686 CDD:416386 31/91 (34%)
Ig strand A 597..599 CDD:409353 1/3 (33%)
Ig strand B 611..620 CDD:409353 1/8 (13%)
Ig strand C 625..632 CDD:409353 3/6 (50%)
Ig strand C' 634..636 CDD:409353 0/1 (0%)
Ig strand D 643..648 CDD:409353 2/4 (50%)
Ig strand E 651..658 CDD:409353 4/6 (67%)
Ig strand F 665..673 CDD:409353 6/7 (86%)
Ig strand G 676..685 CDD:409353 2/8 (25%)
Ig_DSCAM 689..784 CDD:409397 32/94 (34%)
Ig strand B 707..711 CDD:409397 2/3 (67%)
Ig strand C 720..724 CDD:409397 1/3 (33%)
Ig strand E 749..753 CDD:409397 3/3 (100%)
Ig strand F 763..768 CDD:409397 3/4 (75%)
Ig strand G 777..780 CDD:409397 1/2 (50%)
Ig_DSCAM 785..884 CDD:409398 22/103 (21%)
Ig strand B 805..809 CDD:409398 0/3 (0%)
Ig strand C 818..822 CDD:409398 1/3 (33%)
Ig strand E 848..852 CDD:409398 0/3 (0%)
Ig strand F 862..867 CDD:409398 1/4 (25%)
Ig strand G 875..878 CDD:409398 1/2 (50%)
FN3 885..978 CDD:238020 12/110 (11%)
FN3 986..1083 CDD:238020 25/100 (25%)
FN3 1091..1184 CDD:238020 15/92 (16%)
FN3 1189..1278 CDD:238020 24/93 (26%)
Ig_3 1287..1363 CDD:404760 18/79 (23%)
Ig strand B 1303..1307 CDD:409353 2/3 (67%)
Ig strand C 1316..1320 CDD:409353 1/3 (33%)
Ig strand E 1342..1346 CDD:409353 0/3 (0%)
Ig strand F 1356..1361 CDD:409353 0/4 (0%)
FN3 1380..1470 CDD:238020 25/111 (23%)
FN3 1486..1555 CDD:238020 19/111 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10075
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.910

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