DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment tutl and MDGA2

DIOPT Version :9

Sequence 1:NP_001303307.1 Gene:tutl / 46015 FlyBaseID:FBgn0010473 Length:1536 Species:Drosophila melanogaster
Sequence 2:NP_001106970.4 Gene:MDGA2 / 161357 HGNCID:19835 Length:1025 Species:Homo sapiens


Alignment Length:890 Identity:194/890 - (21%)
Similarity:308/890 - (34%) Gaps:255/890 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 NTEKSKEQQ-----QQSQPLEI---------PEQRASKCRGDI-DRTTTTTIPASKTLTASPAKT 70
            |.|:.:..:     ::.:.||:         |:.|.:|..|.. ||...:::             
Human   108 NIEEERYSERVYTIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSV------------- 159

  Fly    71 AAFTVKTTRRRRSRRRAEGSSICVPIRRGQGSTPTPTIQVLQFVLVSLLALLAKNAQAHNIPEDA 135
                ...|.|..:.:|.:|.........|.||....:|:|                ..:.:.:..
Human   160 ----FNETLRITNIQRHQGGRYYCKAENGLGSPAIKSIRV----------------DVYYLDDPV 204

  Fly   136 VHITAILGEG---------VIFNCHVEFPNDHPVPYVLQWDKKVSETGSDLPIYIWYESYPEHIE 191
            |.:...:||.         |...|...  ::.||.|..:..::|...|||..:.| ||       
Human   205 VTVHQSIGEAKEQFYYERTVFLRCVAN--SNPPVRYSWRRGQEVLLQGSDKGVEI-YE------- 259

  Fly   192 EGYKGRVSRVSQDSPFGSAS----LNLTNIRESDQGWYEC------------KVVFLNRDPKQHK 240
                          ||.:..    |.|.|:|..|...|.|            |:|......|.  
Human   260 --------------PFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKMVSFRLSNKT-- 308

  Fly   241 NGTWFHLDVHAPPRFSVTPEDIIYVNLGDSIILNC-QADGTPTPEILWYKDANPVDPSPTVGIFN 304
                      |.|...:..:|.|.||.|::|.|.| ...|.|.|.:.|.:....: |..||  .|
Human   309 ----------ASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTL-PEKTV--LN 360

  Fly   305 DGTELRISTIRHEDIGEYTCIARNGEGQVSHTARVIIAGG---AVIMVPPTNQTKLE----GEKV 362
            .|| |.|..|..:|.|.|:|||.|..|..:..:..||...   ....:.|....|.:    |.:|
Human   361 GGT-LTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREV 424

  Fly   363 IFSCEAKAMPG-NVTVRWYREGSPVREVAALETRVTIRKD-------GSLIINPIKPDDSGQYLC 419
            ..||:.:|:|. .:|..|::.|.|:|   :.|..|..:.|       .:|.|..:|..|.|.|.|
Human   425 KISCQVEAVPSEELTFSWFKNGRPLR---SSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTC 486

  Fly   420 EVT---NGIGDPQSASAYLSVEYPAKVTFTPTVQYLPFRLAGVV---------QCYIKSSPQLQY 472
            ..:   .||.|       :|::.....:..|....:|...:.:|         ||.:...|: ..
Human   487 VASLKGGGISD-------ISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPK-PI 543

  Fly   473 VTWTK-DKRLLEP---YQMKDIVVMANGSLLFTRVNEEHQGQYAC--TPYNAQGTAGASGVMDVL 531
            :.|:: ||.:..|   .||:..    :|:|....|:.|..|.|.|  :.||.........::.::
Human   544 ILWSRADKEVAMPDGSMQMESY----DGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLI 604

  Fly   532 VRKPPAFTVEPETLYQRKVGD-SVEMHCDALEAEGTERPTIKWQ---------RQEGEQLTESQR 586
            |:.|||  |||..|..|:..| ||.|.|..|.|......|.:|:         :.:.::.||   
Human   605 VQYPPA--VEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTE--- 664

  Fly   587 NRIKISGGNITIENLRREDFGYYQCVVSNEVATLMAVTQLVIEGTQPHAPYNITGKATES----- 646
                     ..:::|..|::|.|.|.:.||...             ....:.:||||...     
Human   665 ---------YAVKSLSNENYGVYNCSIINEAGA-------------GRCSFLVTGKAYAPEFYYD 707

  Fly   647 -------------SITLQWLPGYSGGSEYKQDYTIWFREAGVNDWQTISVTPSGSTQ----VTIN 694
                         |.:|||........:....|.:..|:||...|....:..:|:.|    :|.|
Human   708 TYNPVWQNRHRVYSYSLQWTQMNPDAVDRIVAYRLGIRQAGQQRWWEQEIKINGNIQKGELITYN 772

  Fly   695 --GLASGTTYEFQVVGRNVLGDGMMSKVMTVRTLE-DAPAAPR-----------NVKAATQPPDS 745
              .|.....||.::......|:|    ..|:|.:: .||..|.           |:...||    
Human   773 LTELIKPEAYEVRLTPLTKFGEG----DSTIRVIKYSAPVNPHLREFHCGFEDGNICLFTQ---- 829

  Fly   746 FFQLMPDEADLLAYFDIYFHTDSRGTLVYSP---PKLRVKGPKPG 787
                  |:.|   .||....:.:.....|:|   |.....|.|.|
Human   830 ------DDTD---NFDWTKQSTATRNTKYTPNTGPNADRSGSKEG 865

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tutlNP_001303307.1 V-set 137..250 CDD:284989 26/137 (19%)
IG_like 137..229 CDD:214653 23/116 (20%)
I-set 253..341 CDD:254352 30/88 (34%)
IGc2 268..331 CDD:197706 24/63 (38%)
I-set 346..437 CDD:254352 26/105 (25%)
Ig 349..437 CDD:299845 26/102 (25%)
Ig 459..530 CDD:299845 19/85 (22%)
IG_like 549..628 CDD:214653 18/88 (20%)
IGc2 551..617 CDD:197706 17/75 (23%)
FN3 633..725 CDD:238020 23/115 (20%)
FN3 786..874 CDD:238020 1/2 (50%)
MDGA2NP_001106970.4 IG 117..197 CDD:214652 17/112 (15%)
Ig_3 203..288 CDD:404760 24/108 (22%)
Ig strand B 224..228 CDD:409353 1/3 (33%)
Ig strand C 237..241 CDD:409353 1/3 (33%)
Ig strand E 268..272 CDD:409353 1/3 (33%)
Ig strand F 282..287 CDD:409353 2/4 (50%)
Ig strand A 313..317 CDD:409353 0/3 (0%)
IGc2 325..386 CDD:197706 24/64 (38%)
Ig strand B 327..337 CDD:409353 3/9 (33%)
Ig strand C 343..347 CDD:409353 0/3 (0%)
Ig strand C' 349..351 CDD:409353 0/1 (0%)
Ig strand D 356..361 CDD:409353 2/6 (33%)
Ig strand E 362..368 CDD:409353 4/6 (67%)
Ig strand F 375..383 CDD:409353 5/7 (71%)
Ig 418..493 CDD:416386 21/77 (27%)
Ig strand B 424..428 CDD:409353 1/3 (33%)
Ig strand C 439..443 CDD:409353 1/3 (33%)
Ig strand E 469..473 CDD:409353 1/3 (33%)
Ig strand F 483..488 CDD:409353 2/4 (50%)
Ig strand G 497..500 CDD:409353 1/9 (11%)
Ig_3 510..587 CDD:404760 19/81 (23%)
Ig strand A 511..514 CDD:409353 0/2 (0%)
Ig strand A' 519..524 CDD:409353 0/4 (0%)
Ig strand B 530..537 CDD:409353 2/6 (33%)
Ig strand C 543..548 CDD:409353 1/4 (25%)
Ig strand C' 550..552 CDD:409353 1/1 (100%)
Ig strand D 560..563 CDD:409353 1/2 (50%)
Ig strand E 567..573 CDD:409353 2/5 (40%)
Ig strand F 580..587 CDD:409353 3/6 (50%)
MAM 817..989 CDD:395504 13/62 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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