DRSC/TRiP Functional Genomics Resources

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Protein Alignment Gel and SCIN

DIOPT Version :9

Sequence 1:NP_524865.2 Gene:Gel / 46008 FlyBaseID:FBgn0010225 Length:798 Species:Drosophila melanogaster
Sequence 2:NP_001106177.1 Gene:SCIN / 85477 HGNCID:21695 Length:715 Species:Homo sapiens


Alignment Length:763 Identity:278/763 - (36%)
Similarity:402/763 - (52%) Gaps:88/763 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    55 ARRVMHPSFANAGRTPGLEIWRIENFEPVIYPKTNYGKFYTGDSFIVLNTIENKKDKKLSWDVHF 119
            ||.:.|..||.||:..||::||||..|.|..|::.:|.||.||:::||:|.  |..:..::.:||
Human     2 ARELYHEEFARAGKQAGLQVWRIEKLELVPVPQSAHGDFYVGDAYLVLHTA--KTSRGFTYHLHF 64

  Fly   120 WLGLETSTDEAGAAAILTVQLDDLLNGGPVQHREVQDHESQLFLSYFKNGIRYEQGGVGTGFKHV 184
            |||.|.|.||:.||||.|||:||.|.|.|||:||:|.:||..|:||||.|::|:.|||.:|..||
Human    65 WLGKECSQDESTAAAIFTVQMDDYLGGKPVQNRELQGYESNDFVSYFKGGLKYKAGGVASGLNHV 129

  Fly   185 ETNAQGETRLFQVKGKRNVRVRQVNLSVSSMNTGDCFILDAGSDIYVYVGSQAKRVEKLKAISAA 249
            .||.....||..|||:|.||..:|.||..|.|.|||||:|.|::||.:.||...:.|:|||...|
Human   130 LTNDLTAKRLLHVKGRRVVRATEVPLSWDSFNKGDCFIIDLGTEIYQWCGSSCNKYERLKANQVA 194

  Fly   250 NQIRDQDHNGRARVQIVDDFSTDADKQHFFDVLGSGSADQVPDESTADEDSAFERTDAAAVSLYK 314
            ..||..:..||:.:.:|::.|   :......||  |...::||... |:|...:.::.....||.
Human   195 TGIRYNERKGRSELIVVEEGS---EPSELIKVL--GEKPELPDGGD-DDDIIADISNRKMAKLYM 253

  Fly   315 VSDASGKLKVDIIGQK-PLTQAMLDTRECFILDTGSG--IFVWVGKGATQKEKTDAMAKAQEFLR 376
            ||||||.::|.::.:: |.:.|||.:.||||||.|:.  ||||.||.|..:|:..||..|:|||:
Human   254 VSDASGSMRVTVVAEENPFSMAMLLSEECFILDHGAAKQIFVWKGKDANPQERKAAMKTAEEFLQ 318

  Fly   377 TKKYPAWTQIHRIVEGSESAPFKQYFDTWRDAGMSHSRLIRSALGIG----SDELLNDDEIDSVV 437
            ...|...|||..:.||.|:..|||:|..|||...|.        |.|    ::::....:|....
Human   319 QMNYSKNTQIQVLPEGGETPIFKQFFKDWRDKDQSD--------GFGKVYVTEKVAQIKQIPFDA 375

  Fly   438 TQLKKSGGRAFGF-MPDHGQNVIETITQYVAKPGSDEIVVSTVPFDEKLPLLGFASYVLTYNYEA 501
            ::|..|...|... |.|.|...:|  ...|...|  .|.|....:.|   ..|...|::.|.|  
Human   376 SKLHSSPQMAAQHNMVDDGSGKVE--IWRVENNG--RIQVDQNSYGE---FYGGDCYIILYTY-- 431

  Fly   502 NNGDTGSLTYVWHGVKA------SAAARKRAFEEGLVGSKDGLLVQTNQGHEPRHFYKIFKGKLL 560
               ..|.:.|.|.|..|      ::|......:..|.|  ..:.::.:||.||.|...:||.|.|
Human   432 ---PRGQIIYTWQGANATRDELTTSAFLTVQLDRSLGG--QAVQIRVSQGKEPVHLLSLFKDKPL 491

  Fly   561 TSF----------TALPVTAQLFRIRGTVESDVHASEVAADSSSLASSDAFVL----HSGKSHKI 611
            ..:          ...|.| :||::|..:.|.....||..|::||.|:|.|||    :||     
Human   492 IIYKNGTSKKGGQAPAPPT-RLFQVRRNLASITRIVEVDVDANSLNSNDVFVLKLPQNSG----- 550

  Fly   612 YIWNGLGASAFEKQAAVDRFSDYWDDV---ELEQVEEGAEPDEFWEELNGEGQYDRSLGDDGAPL 673
            |||.|.|||..|::.|     :|...|   :..:::||.||:|||..|.|:..|..|      ||
Human   551 YIWVGKGASQEEEKGA-----EYVASVLKCKTLRIQEGEEPEEFWNSLGGKKDYQTS------PL 604

  Fly   674 LES-------RLFHCHLSSGGFLKVEEV-AQYEQEDLDSDDIMLLDAGDEIYLWVGYGVSEEENG 730
            ||:       ||:.|...:|.|: :||: .::.|:||..||:|||||.::|::|:|...:|.|..
Human   605 LETQAEDHPPRLYGCSNKTGRFV-IEEIPGEFTQDDLAEDDVMLLDAWEQIFIWIGKDANEVEKK 668

  Fly   731 KLLDTAKLYFNLEPTARSFDTVSIIRVPQGKEPRVFKRMFPNWDDNYW 778
            :.|.:||:|...:|:.|...| .|:.:.||.||..|...|..||.:.|
Human   669 ESLKSAKMYLETDPSGRDKRT-PIVIIKQGHEPPTFTGWFLGWDSSKW 715

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GelNP_524865.2 gelsolin_S1_like 63..176 CDD:200446 57/112 (51%)
gelsolin_S2_like 191..283 CDD:200445 36/91 (40%)
gelsolin_S3_like 307..404 CDD:200448 45/99 (45%)
ADF_gelsolin 470..558 CDD:301701 23/93 (25%)
ADF_gelsolin 569..661 CDD:301701 37/98 (38%)
gelsolin_S6_like 675..774 CDD:200447 37/106 (35%)
SCINNP_001106177.1 Actin-severing. /evidence=ECO:0000255 1..363 161/376 (43%)
gelsolin_S1_like 10..121 CDD:200446 57/112 (51%)
Polyphosphoinositide binding. /evidence=ECO:0000250 112..119 3/6 (50%)
gelsolin_S2_like 136..225 CDD:200445 37/93 (40%)
Polyphosphoinositide binding. /evidence=ECO:0000250 138..146 5/7 (71%)
gelsolin_S3_like 246..346 CDD:200448 45/99 (45%)
Ca(2+)-dependent actin binding 364..715 116/383 (30%)
gelsolin_S4_like 390..486 CDD:200449 26/109 (24%)
gelsolin_S5_like 508..598 CDD:200444 38/100 (38%)
gelsolin_S6_like 613..711 CDD:200447 36/99 (36%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165141461
Domainoid 1 1.000 92 1.000 Domainoid score I7598
eggNOG 1 0.900 - - E1_KOG0443
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 455 1.000 Inparanoid score I1590
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG55329
OrthoDB 1 1.010 - - D1376537at2759
OrthoFinder 1 1.000 - - FOG0000527
OrthoInspector 1 1.000 - - otm41645
orthoMCL 1 0.900 - - OOG6_100298
Panther 1 1.100 - - O PTHR11977
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2540
SonicParanoid 1 1.000 - - X232
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1413.840

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