DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gel and VLN5

DIOPT Version :9

Sequence 1:	NP_524865.2	Gene:	Gel / 46008	FlyBaseID:	FBgn0010225	Length:	798	Species:	Drosophila melanogaster
Sequence 2:	NP_001318818.1	Gene:	VLN5 / 835837	AraportID:	AT5G57320	Length:	962	Species:	Arabidopsis thaliana

Alignment Length:	759	Identity:	240/759 - (31%)
Similarity:	387/759 - (50%)	Gaps:	80/759 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 RVMHPSFANAGRTPGLEIWRIENFEPVIYPKTNYGKFYTGDSFIVLNTIENKKDKKLSWDVHFWL 121
            |.:..:...||:..|:||||||||:||..|:.::|||:||||:|||.|..::.. .|..|:|:||
plant     6 RDLDQALQGAGQKSGIEIWRIENFKPVTVPQESHGKFFTGDSYIVLKTTASRSG-SLHHDIHYWL 69

  Fly   122 GLETSTDEAGAAAILTVQLDDLLNGGPVQHREVQDHESQLFLSYFKNGIRYEQGGVGTGFKHVET 186
            |.::|.|||||.|::||:||..|.|..||:||||.||::.||||||..|..::|||.:||.||:.
plant    70 GKDSSQDEAGAVAVMTVELDSALGGRAVQYREVQGHETEKFLSYFKPCIIPQEGGVASGFNHVKP 134

  Fly   187 NAQGETRLFQVKGKRNVRVRQVNLSVSSMNTGDCFILDAGSDIYVYVGSQAKRVEKLKAISAANQ 251
            . :.:|||:..|||..|||::|....|::|..|.||||..|.|:.:.||::...|:.||:.....
plant   135 E-EHQTRLYICKGKHVVRVKEVPFVRSTLNHEDVFILDTESKIFQFSGSKSSIQERAKALEVVQY 198

  Fly   252 IRDQDHNGRARVQIVDD--FSTDADKQHFFDVLGSGSADQVPDESTADEDSAFERTDAAAVSLYK 314
            |:|..|:|:..:..|:|  ...||:...|:.:.| |.| .:|.:...::|   |...:..:.|:.
plant   199 IKDTYHDGKCDIAAVEDGRMMADAEAGEFWGLFG-GFA-PLPKKPAVNDD---ETAASDGIKLFS 258

  Fly   315 VSDASGKLKVDIIGQKPLTQAMLDTRECFILDTGSGIFVWVGKGATQKEKTDAMAKAQEFLRTKK 379
            |.    |.:.|.:..:.||:.:|||.:|:|||.|..:|||.|:..:..::..|...|:||.|:.:
plant   259 VE----KGQTDAVEAECLTKELLDTNKCYILDCGLELFVWKGRSTSIDQRKSATEAAEEFFRSSE 319

  Fly   380 YPAWTQIHRIVEGSESAPFKQYFDTWRDAGMSHSRLIRSALGIGSDELLNDDEIDSVVTQLKKSG 444
             |..:.:..::||.|:..|:..||:|    .:.|.:.....|.|           .|...|::.|
plant   320 -PPKSNLVSVMEGYETVMFRSKFDSW----PASSTIAEPQQGRG-----------KVAALLQRQG 368

  Fly   445 GRAFGFMPDHGQNVIETITQYVAKPGSDEIVVSTVPFDEKLPLLGFAS---------YVLTYNYE 500
            ....|.:.....:..:....|:  .|:..:.|..:..:||: ||..|.         |:|.|:|.
plant   369 VNVQGLVKTSSSSSKDEPKPYI--DGTGNLQVWRINCEEKI-LLEAAEQSKFYSGDCYILQYSYP 430

  Fly   501 ANNGDTGSLTYVWHGVKASAAARKRAFE--EGLVGSKDGLLVQT--NQGHEPRHFYKI------F 555
            ..:.:. .|...|.|.::....|..|..  ..:|.|...:..|.  |:|.||..|:.|      |
plant   431 GEDREE-HLVGTWFGKQSVEEDRASAISLANKMVESMKFVPAQARINEGKEPIQFFVIMQSFITF 494

  Fly   556 KGKLLTSF------TALPVT------AQLFRIRGTVESDVHASEVAADSSSLASSDAFVLHSGKS 608
            ||.:..:|      ..:|.|      ..|||::|:...::.|.::.|.|:.|.||..::||...:
plant   495 KGGVSDAFKKYIAENDIPDTTYEAEGVALFRVQGSGPENMQAIQIEAASAGLNSSHCYILHGDST 559

  Fly   609 HKIYIWNGLGASAFEKQAAVDRFSDYWDDVELEQVE-EGAEPDEFWEELNGEGQY-DRSLGDDGA 671
              ::.|.| ..::.|.|..::|..|.....|..:.: ||:|.::|||.|.|:.:| .:.:..||.
plant   560 --VFTWCG-NLTSSEDQELMERMLDLIKPNEPTKAQKEGSESEQFWELLGGKSEYPSQKIKRDGE 621

  Fly   672 PLLESRLFHCHLSSGGFLKVEEVAQYEQEDLDSDDIMLLDAGDEIYLWVGYGVSEEENGKLLDTA 736
            .  :..||.|..::.. ||..|:..:.|:||.::||.:||...|:::|||..|..::..:.||..
plant   622 S--DPHLFSCTYTNES-LKATEIFNFTQDDLMTEDIFILDCHTEVFVWVGQQVDPKKKPQALDIG 683

  Fly   737 KLY----FNLEPTARSFDTVSIIRVPQGKEPRVFKRMFPNWDDN 776
            :.:    |.||..|   ....|..|.:|.||..|.|.| .||.:
plant   684 ENFLKHDFLLENLA---SETPIYIVTEGNEPPFFTRFF-TWDSS 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gel	NP_524865.2	gelsolin_S1_like	63..176	CDD:200446	59/112 (53%)
		gelsolin_S2_like	191..283	CDD:200445	33/93 (35%)
		gelsolin_S3_like	307..404	CDD:200448	29/96 (30%)
		ADF_gelsolin	470..558	CDD:301701	27/106 (25%)
		ADF_gelsolin	569..661	CDD:301701	28/98 (29%)
		gelsolin_S6_like	675..774	CDD:200447	32/102 (31%)
VLN5	NP_001318818.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	97	1.000	Domainoid score	I2427
eggNOG	1	0.900	-	-		E1_KOG0443
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	339	1.000	Inparanoid score	I645
OMA	1	1.010	-	-		QHG55329
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	1	1.000	-	-		FOG0000527
OrthoInspector	1	1.000	-	-		otm2577
orthoMCL	1	0.900	-	-		OOG6_100298
Panther	1	1.100	-	-	O	PTHR11977
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X232
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840