DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gel and VLN3

DIOPT Version :9

Sequence 1:	NP_524865.2	Gene:	Gel / 46008	FlyBaseID:	FBgn0010225	Length:	798	Species:	Drosophila melanogaster
Sequence 2:	NP_001319779.1	Gene:	VLN3 / 824908	AraportID:	AT3G57410	Length:	965	Species:	Arabidopsis thaliana

Alignment Length:	785	Identity:	242/785 - (30%)
Similarity:	386/785 - (49%)	Gaps:	88/785 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 RVMHPSFANAGRTPGLEIWRIENFEPVIYPKTNYGKFYTGDSFIVLNTIENKKDKKLSWDVHFWL 121
            :|:.|:|...|:.||.|||||||||||..||:.:||||.||::|||.|.:||....| :|:|||:
plant     6 KVLDPAFQGVGQKPGTEIWRIENFEPVPVPKSEHGKFYMGDTYIVLQTTQNKGGAYL-FDIHFWI 69

  Fly   122 GLETSTDEAGAAAILTVQLDDLLNGGPVQHREVQDHESQLFLSYFKNGIRYEQGGVGTGFKHVET 186
            |.:||.||||.||:.||:||..|.|..||:||:|.|||..||||||..|...:|||.:|||..|
plant    70 GKDTSQDEAGTAAVKTVELDAALGGRAVQYREIQGHESDKFLSYFKPCIIPLEGGVASGFKKPE- 133

  Fly   187 NAQGETRLFQVKGKRNVRVRQVNLSVSSMNTGDCFILDAGSDIYVYVGSQAKRVEKLKAISAANQ 251
            ..:.||||:..||||.|.::||..:.||:|..|.||||....||.:.|:.:...|:.||:.....
plant   134 EEEFETRLYTCKGKRAVHLKQVPFARSSLNHDDVFILDTKEKIYQFNGANSNIQERAKALVVIQY 198

  Fly   252 IRDQDHNGRARVQIVDD--FSTDADKQHFFDVLGS--------GSADQVPDESTADEDSAFERTD 306
            ::|:.|.|.:.|.||||  ..|::|...|:.:.|.        .|.|::..|:|..:
plant   199 LKDKFHEGTSDVAIVDDGKLDTESDSGEFWVLFGGFAPIARKVASEDEIIPETTPPK-------- 255

  Fly   307 AAAVSLYKVSDASGKLKVDIIGQKPLTQAMLDTRECFILDTGSGIFVWVGKGATQKEKTDAMAKA 371
                 ||.::|  |::: .|.|.  |:::||:..:|::||.||.||:|||:....:|:..|:..|
plant   256 -----LYSIAD--GQVE-SIDGD--LSKSMLENNKCYLLDCGSEIFIWVGRVTQVEERKTAIQAA 310

  Fly   372 QEFLRTKKYPAWTQIHRIVEGSESAPFKQYFDTW--------RDAGMSHSRLIRSALGIGSDELL 428
            ::|:.::..|..|:|.|:::|.|...||..||:|        .:.|......:....|:|...|.
plant   311 EDFVASENRPKATRITRVIQGYEPHSFKSNFDSWPSGSATPANEEGRGKVAALLKQQGVGLKGLS 375

  Fly   429 NDDEIDSVVTQLKKSGGRAFGFMPDHGQNVIETITQYVAKPGSDEIVVSTVPFDEKLPLLGFASY 493
            ....::..:..|.:.||:...:..|.....:.: ..:|.|..|.:                  .|
plant   376 KSTPVNEDIPPLLEGGGKLEVWYIDANSKTVLS-KDHVGKLYSGD------------------CY 421

  Fly   494 VLTYNYEANNGDTGSLTYVWHGVKASAAARKRA--FEEGLVGSKDGLLVQTN--QGHEPRHFYKI 554
            ::.|.|.:...........|.|..::...::.|  ....:..|..|..||..  :|.||..|..:
plant   422 LVLYTYHSGERKEDYFLCCWFGKNSNQEDQETAVRLASTMTNSLKGRPVQARIFEGKEPPQFVAL 486

  Fly   555 F------KGKLLTSF------------TALPVTAQLFRIRGTVESDVHASEVAADSSSLASSDAF 601
            |      ||.|.:.:            |..|.:..|.::.||...:..|.:|.|.::||.|.|.|
plant   487 FQHMVVLKGGLSSGYKNSMTEKGSSGETYTPESIALIQVSGTGVHNNKALQVEAVATSLNSYDCF 551

  Fly   602 VLHSGKSHKIYIWNGLGASAFEKQAAVDRFSDYW-DDVELEQVEEGAEPDEFWEELNGEGQYDRS 665
            :|.||.|  :::|.| ..|..|:|....:.:::. ....::..:||.|...||..|.|:..: .|
plant   552 LLQSGTS--MFLWVG-NHSTHEQQELAAKVAEFLKPGTTIKHAKEGTESSSFWFALGGKQNF-TS 612

  Fly   666 LGDDGAPLLESRLFHCHLSSGGFLKVEEVAQYEQEDLDSDDIMLLDAGDEIYLWVGYGVSEEENG 730
            .......:.:..||....:.|.| :|||:..::|:||.::::.|||...|:::|||..|..:|..
plant   613 KKVSSETVRDPHLFSFSFNRGKF-QVEEIHNFDQDDLLTEEMHLLDTHAEVFVWVGQCVDPKEKQ 676

  Fly   731 KLLDTAKLYFNLEPTARSFD-TVSIIRVPQGKEPRVFKRMFPNWDDNYWQNQ-PSYEDMKQLVID 793
            ...:..:.|.||..:..... .|.:.::.:|.||..|...| :||......| .||:....|::.
plant   677 TAFEIGQRYINLAGSLEGLSPKVPLYKITEGNEPCFFTTYF-SWDSTKATVQGNSYQKKAALLLG 740

  Fly   794 ANNEV 798
            .::.|
plant   741 THHVV 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gel	NP_524865.2	gelsolin_S1_like	63..176	CDD:200446	64/112 (57%)
		gelsolin_S2_like	191..283	CDD:200445	36/93 (39%)
		gelsolin_S3_like	307..404	CDD:200448	32/96 (33%)
		ADF_gelsolin	470..558	CDD:301701	17/97 (18%)
		ADF_gelsolin	569..661	CDD:301701	27/92 (29%)
		gelsolin_S6_like	675..774	CDD:200447	28/99 (28%)
VLN3	NP_001319779.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	97	1.000	Domainoid score	I2427
eggNOG	1	0.900	-	-		E1_KOG0443
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	339	1.000	Inparanoid score	I645
OMA	1	1.010	-	-		QHG55329
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	1	1.000	-	-		FOG0000527
OrthoInspector	1	1.000	-	-		otm2577
orthoMCL	1	0.900	-	-		OOG6_100298
Panther	1	1.100	-	-	O	PTHR11977
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X232
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840