DRSC/TRiP Functional Genomics Resources

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Protein Alignment Gel and CAPG

DIOPT Version :9

Sequence 1:NP_524865.2 Gene:Gel / 46008 FlyBaseID:FBgn0010225 Length:798 Species:Drosophila melanogaster
Sequence 2:NP_001243068.1 Gene:CAPG / 822 HGNCID:1474 Length:348 Species:Homo sapiens


Alignment Length:348 Identity:135/348 - (38%)
Similarity:209/348 - (60%) Gaps:15/348 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly    63 FANAGRTPGLEIWRIENFEPVIYPKTNYGKFYTGDSFIVLNTIENKKDKKLSWDVHFWLGLETST 127
            |..:.:.|||.:||:|..:||...:.|.|.|::|||::||    :...:::| .:|.|:|.::|.
Human    12 FPGSVQDPGLHVWRVEKLKPVPVAQENQGVFFSGDSYLVL----HNGPEEVS-HLHLWIGQQSSR 71

  Fly   128 DEAGAAAILTVQLDDLLNGGPVQHREVQDHESQLFLSYFKNGIRYEQGGVGTGFKHVETNAQGE- 191
            ||.||.|:|.|.|:.||...||||||||.:||.||:|||..|::|::|||.:.|....|.|... 
Human    72 DEQGACAVLAVHLNTLLGERPVQHREVQGNESDLFMSYFPRGLKYQEGGVESAFHKTSTGAPAAI 136

  Fly   192 TRLFQVKGKRNVRVRQVNLSVSSMNTGDCFILDAGSDIYVYVGSQAKRVEKLKAISAANQIRDQD 256
            .:|:|||||:|:|..:..|:..|.|||||||||.|.:|:.:.|.::..:|:.||...|..|||.:
Human   137 KKLYQVKGKKNIRATERALNWDSFNTGDCFILDLGQNIFAWCGGKSNILERNKARDLALAIRDSE 201

  Fly   257 HNGRARVQIVDDFSTDADKQHFFDVLGSGSADQVPDESTADEDSAFERTDAAAVSLYKVSDASGK 321
            ..|:|:|:||.|....|:   ...|||...|.:   |...:||...::.:|.|.:|||||||:|:
Human   202 RQGKAQVEIVTDGEEPAE---MIQVLGPKPALK---EGNPEEDLTADKANAQAAALYKVSDATGQ 260

  Fly   322 LKV-DIIGQKPLTQAMLDTRECFILDTG--SGIFVWVGKGATQKEKTDAMAKAQEFLRTKKYPAW 383
            :.: .:....|....:|.:.:||:||.|  ..|::|.|:.|.:||:..|:..|:.|:...:|...
Human   261 MNLTKVADSSPFALELLISDDCFVLDNGLCGKIYIWKGRKANEKERQAALQVAEGFISRMQYAPN 325

  Fly   384 TQIHRIVEGSESAPFKQYFDTWR 406
            ||:..:.:|.||..|||:|..|:
Human   326 TQVEILPQGHESPIFKQFFKDWK 348

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GelNP_524865.2 gelsolin_S1_like 63..176 CDD:200446 49/112 (44%)
gelsolin_S2_like 191..283 CDD:200445 37/92 (40%)
gelsolin_S3_like 307..404 CDD:200448 36/99 (36%)
ADF_gelsolin 470..558 CDD:301701
ADF_gelsolin 569..661 CDD:301701
gelsolin_S6_like 675..774 CDD:200447
CAPGNP_001243068.1 gelsolin_S1_like 17..120 CDD:200446 48/107 (45%)
Gelsolin-like 1 27..75 18/52 (35%)
gelsolin_S2_like 137..225 CDD:200445 37/90 (41%)
Nuclear localization signal. /evidence=ECO:0000255 137..146 5/8 (63%)
Gelsolin-like 2 148..188 16/39 (41%)
gelsolin_S3_like 251..346 CDD:200448 34/94 (36%)
Gelsolin-like 3 261..307 13/45 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165141463
Domainoid 1 1.000 64 1.000 Domainoid score I10103
eggNOG 1 0.900 - - E1_KOG0443
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1376537at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11977
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.850

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