DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gel and VLN1

DIOPT Version :9

Sequence 1:	NP_524865.2	Gene:	Gel / 46008	FlyBaseID:	FBgn0010225	Length:	798	Species:	Drosophila melanogaster
Sequence 2:	NP_001189635.1	Gene:	VLN1 / 817539	AraportID:	AT2G29890	Length:	933	Species:	Arabidopsis thaliana

Alignment Length:	749	Identity:	221/749 - (29%)
Similarity:	359/749 - (47%)	Gaps:	79/749 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 SFANAGRTPGLEIWRIENFEPVIYPKTNYGKFYTGDSFIVLNTIENKKDKKLSWDVHFWLGLETS 126
            :|...|...|||||.:.|.:.:..||:::|||::|::::||.|...|.:.. .:|:|:|||::.:
plant    11 AFQGVGTKSGLEIWCVYNKQLISIPKSSFGKFHSGNAYLVLRTFLRKIESP-QYDIHYWLGIDAN 74

  Fly   127 TDEAGAAAILTVQLDDLLNGGPVQHREVQDHESQLFLSYFKNGIRYEQGGVGTGFKHVETNAQGE 191
            ..::..|:...:.||..|....||:||||..|::.||||||..|...:|....     :|...||
plant    75 EVDSILASDKALDLDAALGCCTVQYREVQGQETEKFLSYFKPCIIPVEGKYSP-----KTGIAGE 134

  Fly   192 T---RLFQVKGKRNVRVRQVNLSVSSMNTGDCFILDAGSDIYVYVGSQAKRVEKLKAISAANQIR 253
            |   .|.:.||...|||::|....||:|..|.||||..|.::::.|..:...||.||:.....|:
plant   135 TYQVTLLRCKGDHVVRVKEVPFLRSSLNHDDVFILDTASKVFLFAGCNSSTQEKAKAMEVVEYIK 199

  Fly   254 DQDHNGRARVQIVDD--FSTDADKQHFFDVLGSGSADQVPDESTADEDSAFERTDAAAVSLYKVS 316
            |..|:||..|..::|  ||.|:|...|:...| |.| .:|..|::   :..|:|......|:.:
plant   200 DNKHDGRCEVATIEDGKFSGDSDAGEFWSFFG-GYA-PIPKLSSS---TTQEQTQTPCAELFWI- 258

  Fly   317 DASGKLKVDIIGQKPLTQAMLDTRECFILDTGSGIFVWVGKGATQKEKTDAMAKAQEFLRTKKYP 381
            |..|.|..  .|...|.:.||:..:|::||..|.:|||:|:..:..|:..:::.::||||.:...
plant   259 DTKGNLHP--TGTSSLDKDMLEKNKCYMLDCHSEVFVWMGRNTSLTERKTSISSSEEFLRKEGRS 321

  Fly   382 AWTQIHRIVEGSESAPFKQYFDTWRDAGMSHSRLIRSALGIGSDELLNDDEIDSVVTQLKKSGGR 446
            ..|.:..:.||.|:|.|:.:|:.|       .:.:.|:|         .:|....|..|.|..|.
plant   322 TTTSLVLLTEGLENARFRSFFNKW-------PQTVESSL---------YNEGREKVAALFKQKGY 370

  Fly   447 AFGFMPDHGQNVIETITQ---YVAKPGSDEIVVSTVPFDEKLPLLGFAS--YVLTYNYEANNGDT 506
            ....:||...:.:.|..:   .|.:...|::.:.::|...||    |..  |::.|.|.... .|
plant   371 DVEELPDEEDDPLYTNCRDNLKVWRVDGDDVSLLSIPDQTKL----FTGDCYLVQYKYTYKE-RT 430

  Fly   507 GSLTYVWHGVKASAAARKRAF--EEGLVGSKDG--LLVQTNQGHEPRHFYK------IFKGKLLT 561
            ..|.|||.|.::....|..|.  ...:||:..|  :|....||:||..|:.      :|||.|..
plant   431 EHLLYVWIGCESIQQDRADAITNASAIVGTTKGESVLCHIYQGNEPSRFFPMFQSLVVFKGGLSR 495

  Fly   562 SFTALPV------------TAQLFRIRGTVESDVHASEVAADSSSLASSDAFVLHSGKSHKIYIW 614
            .:..|..            .|.|||:.||...::.|.:|...::||.||.:::|..|.|  .:.|
plant   496 RYKVLLAEKEKIGEEYNENKASLFRVVGTSPRNMQAIQVNLVATSLNSSYSYILQYGAS--AFTW 558

  Fly   615 NGLGASAFEKQAAVDRFSDYWDDVELE--QVEEGAEPDEFWEELNGEGQYDRSLGDDGAPLLESR 677
            .|..:|..:.: .:||.. |:.|...:  .:.||.|.|.||..|.|:.:|.:. .:....:.|..
plant   559 IGKLSSDSDHE-VLDRML-YFLDTSCQPIYIREGNETDTFWNLLGGKSEYPKE-KEMRKQIEEPH 620

  Fly   678 LFHCHLSSGG-FLKVEEVAQYEQEDLDSDDIMLLDAGDEIYLWVG--YGVSEEENGKLLDTAKLY 739
            ||.|..|||. .|||:|:..:.|:||.::|:.|||...|:|:|:|  ..:..:|....|....|.
plant   621 LFTCSCSSGNDVLKVKEIYNFVQDDLTTEDVFLLDCQSEVYVWIGSNSNIKSKEEALTLGLKFLE 685

  Fly   740 FNLEPTARSFDTVSIIRVPQGKEPRVFKRMFPNW 773
            .::.....:..| .:..|.:|.||..|.|.| .|
plant   686 MDILEEGLTMRT-PVYVVTEGHEPPFFTRFF-EW 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gel	NP_524865.2	gelsolin_S1_like	63..176	CDD:200446	41/112 (37%)
		gelsolin_S2_like	191..283	CDD:200445	35/96 (36%)
		gelsolin_S3_like	307..404	CDD:200448	28/96 (29%)
		ADF_gelsolin	470..558	CDD:301701	27/99 (27%)
		ADF_gelsolin	569..661	CDD:301701	30/93 (32%)
		gelsolin_S6_like	675..774	CDD:200447	34/102 (33%)
VLN1	NP_001189635.1	gelsolin_S1_like	12..123	CDD:200446	41/111 (37%)
		gelsolin_S2_like	140..231	CDD:200445	33/90 (37%)
		gelsolin_S3_like	245..344	CDD:200448	30/101 (30%)
		gelsolin_S4_like	383..483	CDD:200449	27/104 (26%)
		gelsolin_S5_like	514..605	CDD:200444	30/94 (32%)
		gelsolin_S6_like	618..717	CDD:200447	33/100 (33%)
		VHP	898..933	CDD:128458
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	58	1.000	Domainoid score	I3934
eggNOG	1	0.900	-	-		E1_KOG0443
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	339	1.000	Inparanoid score	I645
OMA	1	1.010	-	-		QHG55329
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm2577
orthoMCL	1	0.900	-	-		OOG6_100298
Panther	1	1.100	-	-	O	PTHR11977
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X232
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.840