DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gel and Avil

DIOPT Version :9

Sequence 1:	NP_524865.2	Gene:	Gel / 46008	FlyBaseID:	FBgn0010225	Length:	798	Species:	Drosophila melanogaster
Sequence 2:	XP_038935869.1	Gene:	Avil / 79253	RGDID:	620301	Length:	848	Species:	Rattus norvegicus

Alignment Length:	808	Identity:	285/808 - (35%)
Similarity:	408/808 - (50%)	Gaps:	123/808 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 SFANAGRT----PGLEIWRIENFEPVIYPKTNYGKFYTGDSFIVLNTIENKKDKKLSWDVHFWLG 122
            |.::|.||    ||:..||||..|.|:.|.:.:|.||.||.:|:|:|  .:....||.::|||:|
  Rat     2 SLSSAFRTVTNDPGIITWRIEKMELVLVPLSAHGNFYEGDCYIILST--RRVGSLLSQNIHFWIG 64

  Fly   123 LETSTDEAGAAAILTVQLDDLLNGGPVQHREVQDHESQLFLSYFKNGIRYEQGGVGTGFKHVETN 187
            .::|.||...|||.|.||||.|.|.||||||||.|||..|..|||.||.|::|||.:|.||||||
  Rat    65 KDSSQDEQSCAAIYTTQLDDYLGGSPVQHREVQYHESDTFRGYFKRGIIYKKGGVASGMKHVETN 129

  Fly   188 AQGETRLFQVKGKRNVRV-----------------------------RQVNLSVSSMNTGDCFIL 223
            .....||..||||||:|.                             .||.:|..|.|.||.|:|
  Rat   130 TYDVKRLLHVKGKRNIRATEVSPTHDCLGPVFLPWPLRPPQTALASPMQVEMSWDSFNQGDVFLL 194

  Fly   224 DAGSDIYVYVGSQAKRVEKLKAISAANQIRDQDHNGRARVQIVDDFSTDADKQH--------FFD 280
            |.|..|..:.|.::...|:|||:..|..|||::..|||.:.::     :.||:.        ..:
  Rat   195 DLGMVIIQWNGPESNSGERLKAMLLAKDIRDRERGGRAEIGVI-----EGDKEAASPELMTVLQN 254

  Fly   281 VLGSGS--ADQVPDESTADEDSAFERTDAAAVSLYKVSDASGKLKVDIIGQKPLTQAMLDTRECF 343
            .||..|  ...||||.|       ::...:.:.||.|||.:|:|.|..:..:||.|.:|:..:|:
  Rat   255 TLGRRSIIKPAVPDEVT-------DQQQKSTIMLYHVSDTTGQLSVTEVATRPLVQELLNHDDCY 312

  Fly   344 ILD-TGSGIFVWVGKGATQKEKTDAMAKAQEFLRTKKYPAWTQIHRIVEGSESAPFKQYFDTW-- 405
            ||| :|:.|:||.|||||:.||..||:||.:|::.|.||:.|.:..:.:|:|||.|||.|..|
  Rat   313 ILDQSGTKIYVWKGKGATKVEKQAAMSKALDFIKMKGYPSSTNVETVNDGAESAMFKQLFQKWSV 377

  Fly   406 --RDAGMSHSRLIRSALGIGSDELLNDDEIDSVVTQLKKSGGRAFGFMPDHGQNVIETITQYVAK 468
              :..|:.      ....||....:..|:.|..:...|.........:.|
  Rat   378 KDQTTGLG------KTFSIGKIAKIFQDKFDVTLLHTKPEVAAQERMVDD--------------- 421

  Fly   469 PGSDEIVVSTVPFDEKLPL--------LGFASYVLTYNYEANNGDTGSLTYVWHGVKAS----AA 521
             |:.::.|..:...|.:|:        .|...|::.|.|:. ||....:.|:|.|..||    ||
  Rat   422 -GNGKVEVWRIENLELVPVEYQWHGFFYGGDCYLVLYTYDV-NGKPCYILYIWQGRHASQDELAA 484

  Fly   522 ARKRAFEEGLVGSKDG---LLVQTNQGHEPRHFYKIFKGKLL-----TSFTA-----LPVTAQLF 573
            :..:|.|   |..:.|   :.|:.:.|.|||||..||||||:     ||...     .||  :||
  Rat   485 SAYQAVE---VDQQFGGAPVQVRVSMGKEPRHFMAIFKGKLVIYEGGTSRKGNVEPDPPV--RLF 544

  Fly   574 RIRGTVESDVHASEVAADSSSLASSDAFVLHSGKSHKIYIWNGLGASAFEKQAAVDRFSDYWDDV 638
            :|.|..:|:..|.||:|.:|||.|:|.|:|.:...|  |:|.|.|:|. :::|.....::...|.
  Rat   545 QIHGNDKSNTKAVEVSASASSLNSNDVFLLWTQAEH--YLWYGKGSSG-DERAMAKELAELLCDG 606

  Fly   639 ELEQVEEGAEPDEFWEELNGEGQY--DRSLGDDGAPLLESRLFHCHLSSGGFLKVEEVAQYEQED 701
            :.:.|.||.||.|||:.|.|:..|  |:.|..:... ::.|||.|...:|.|| |.||..:.|:|
  Rat   607 DADTVAEGQEPPEFWDLLGGKAPYANDKRLQQETLD-IQVRLFECSNKTGRFL-VTEVTDFTQDD 669

  Fly   702 LDSDDIMLLDAGDEIYLWVGYGVSEEENGKLLDTAKLYFNLEPTARSFDTVSIIRVPQGKEPRVF 766
            |...|:||||..|:::||:|...:..|....|.||:.|....|:.|..|| .|:.:.||.||..|
  Rat   670 LSPGDVMLLDTWDQVFLWIGAEANATEKEGALSTAQEYLVTHPSGRDPDT-PILIIKQGFEPPTF 733

  Fly   767 KRMFPNWDDNYWQNQPSYEDMKQLVIDA 794
            ...|..||.:.|....|||.:|..:.||
  Rat   734 TGWFLAWDPHIWSEGKSYEQLKNELGDA 761

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gel	NP_524865.2	gelsolin_S1_like	63..176	CDD:200446	57/116 (49%)
		gelsolin_S2_like	191..283	CDD:200445	35/128 (27%)
		gelsolin_S3_like	307..404	CDD:200448	44/97 (45%)
		ADF_gelsolin	470..558	CDD:301701	31/102 (30%)
		ADF_gelsolin	569..661	CDD:301701	34/91 (37%)
		gelsolin_S6_like	675..774	CDD:200447	38/98 (39%)
Avil	XP_038935869.1	gelsolin_S1_like	7..118	CDD:200446	56/112 (50%)
		gelsolin_S2_like	133..252	CDD:200445	35/123 (28%)
		gelsolin_S3_like	276..374	CDD:200448	44/97 (45%)
		gelsolin_S4_like	418..518	CDD:200449	29/119 (24%)
		gelsolin_S5_like	539..629	CDD:200444	36/94 (38%)
		gelsolin_S6_like	646..741	CDD:200447	38/96 (40%)
		VHP	813..847	CDD:396679
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335151
Domainoid	1	1.000	70	1.000	Domainoid score	I9309
eggNOG	1	0.900	-	-		E1_KOG0443
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	456	1.000	Inparanoid score	I1529
OMA	1	1.010	-	-		QHG55329
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	1	1.000	-	-		FOG0000527
OrthoInspector	1	1.000	-	-		otm45767
orthoMCL	1	0.900	-	-		OOG6_100298
Panther	1	1.100	-	-	O	PTHR11977
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X232
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.810