DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gel and avil

DIOPT Version :9

Sequence 1:	NP_524865.2	Gene:	Gel / 46008	FlyBaseID:	FBgn0010225	Length:	798	Species:	Drosophila melanogaster
Sequence 2:	NP_001035455.1	Gene:	avil / 678618	ZFINID:	ZDB-GENE-060421-6683	Length:	811	Species:	Danio rerio

Alignment Length:	784	Identity:	282/784 - (35%)
Similarity:	393/784 - (50%)	Gaps:	112/784 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 MHPSFANAGRTPGLEIWRIENFEPVIYPKTNYGKFYTGDSFIVLNTIENKKDKKLSWDVHFWLGL 123
            |..:|.....:.|:.|||||..:.|:.|:..:|:|:.||.:::|:|.  |..|.:|:|:|:|:|.
Zfish     1 MQNTFRAVTNSAGVLIWRIEKMDLVLIPEKFHGQFFDGDCYLLLSTC--KSGKTISYDIHYWIGS 63

  Fly   124 ETSTDEAGAAAILTVQLDDLLNGGPVQHREVQDHESQLFLSYFKNGIRYEQGGVGTGFKHVETNA 188
            .:|.||.||||:..||||:.|...||||||||.|||.:|..|||.||.|:.|||.:|..|||||.
Zfish    64 ASSIDEQGAAAMYAVQLDEFLGSTPVQHREVQQHESSMFCGYFKQGIIYKSGGVASGMNHVETNT 128

  Fly   189 QGETRLFQVKGKRNVRVRQVNLSVSSMNTGDCFILDAGSDIYVYVGSQAKRVEKLKAISAANQIR 253
            ....||..|||:|.|...:|.:|..|.:||..|:||.|..|..:.|.::...|:||.:..|..||
Zfish   129 YNIQRLLHVKGRRKVTGTEVEVSWKSFDTGSVFLLDLGKTIIQWNGPESNTQERLKGMMLAKDIR 193

  Fly   254 DQDHNGRARVQIVDDFSTDAD------KQHFFDVLG-------SGSADQVPDESTADEDSAFERT 305
            |::..|||.:.:::.   ||:      .|....:||       ||:.|.|.|           |.
Zfish   194 DRERGGRAEIGVIEG---DAEAAAPLLMQVMLSILGERPSTLPSGTPDDVTD-----------RE 244

  Fly   306 DAAAVSLYKVSDASGKLKVDIIGQKPLTQAMLDTRECFILDTGS-GIFVWVGKGATQKEKTDAMA 369
            ..|.::||.||||:|.:::..|...||||.:|:..:|:|||.|. .||||.||.|.:.|:..||.
Zfish   245 QMAKLTLYHVSDANGTMQITEIATSPLTQDLLNHDDCYILDQGGVSIFVWKGKMANKAERQAAMT 309

  Fly   370 KAQEFLRTKKYPAWTQIHRIVEGSESAPFKQYFDTW------RDAGMSHSRLIRSALGIGSDELL 428
            :|.||::.|.||..|::..|.:|.|||.|||.|..|      :..|.:|:      :|..:|
Zfish   310 RALEFIKLKNYPLSTKVESICDGGESALFKQLFKNWTVKDQTQGLGRTHT------VGKIAD--- 365

  Fly   429 NDDEIDSVVTQLKKSGGRAFGFMPDHGQNVIETITQYVAKPGSDEIVVSTVPFDEKLPL------ 487
                    |.|.|....| ...||:      ....:.:...||.|..|..:   |.|.|
Zfish   366 --------VPQEKFDASR-MHMMPE------VAAQERMVDDGSGEKQVWRI---ENLELAEVSKA 412

  Fly   488 -----LGFASYVLTYNYEANNGDTGSLTYVWHGVKAS-----AAARKRAFEEGLVGSKDGLLVQT 542
                 .|...|::.|:||. ||....:.|:|.|..||     |.|......:...|.:. :.|..
Zfish   413 THGFFYGGDCYLILYSYEV-NGRKNYILYMWRGRHASQDEVTACAYHAVTVDQQYGGQP-VQVSV 475

  Fly   543 NQGHEPRHFYKIFKGKLL-----TSFTALPV----TAQLFRIRGTVESDVHASEVAADSSSLASS 598
            ..|.|||||..|||||::     ||... ||    ..:||:|.|:..|...|.||.|.::||.|:
Zfish   476 TMGKEPRHFTSIFKGKMVIYEGGTSRKG-PVEPEPPVRLFQICGSHPSSTRAVEVPALAASLNSN 539

  Fly   599 DAFVLHSGKSHKIYIWNGLGASAFEKQAAVDRFSDYWDDVEL---EQV-EEGAEPDEFWEELNGE 659
            |.|:|.|...  :|:|.|.|:|..|:..|.|.      .|.:   ||| .||.||:|||:.|.|.
Zfish   540 DVFLLKSQSG--VYLWYGKGSSGDERAMAKDL------SVIMGRSEQVMAEGQEPEEFWQSLGGR 596

  Fly   660 GQY--DRSLGDDGAPLLE--SRLFHCHLSSGGFLKVEEVAQYEQEDLDSDDIMLLDAGDEIYLWV 720
            ..|  ||.|..   ..||  .|||.|...:|.| ...||.|:.|:||..||:||||..|:|:||:
Zfish   597 TPYASDRRLQQ---VTLEHQPRLFECSNKTGRF-TATEVTQFTQDDLREDDVMLLDTWDQIFLWM 657

  Fly   721 GYGVSEEENGKLLDTAKLYFNLEPTARSFDTVSIIRVPQGKEPRVFKRMFPNWDDNYWQNQPSYE 785
            |...::.|..:.:.|...|....|.:|..|| .|:.:.||.||..|...|..||.:.|....:||
Zfish   658 GNEANDVERRECVPTCAEYLRTHPGSRDPDT-PIVIIKQGFEPPTFTGWFTAWDPSKWSGGKTYE 721

  Fly   786 DMKQ 789
            .:||
Zfish   722 QLKQ 725

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gel	NP_524865.2	gelsolin_S1_like	63..176	CDD:200446	52/112 (46%)
		gelsolin_S2_like	191..283	CDD:200445	31/97 (32%)
		gelsolin_S3_like	307..404	CDD:200448	45/97 (46%)
		ADF_gelsolin	470..558	CDD:301701	32/103 (31%)
		ADF_gelsolin	569..661	CDD:301701	37/95 (39%)
		gelsolin_S6_like	675..774	CDD:200447	38/100 (38%)
avil	NP_001035455.1	gelsolin_S1_like	5..116	CDD:200446	52/112 (46%)
		gelsolin_S2_like	132..226	CDD:200445	31/96 (32%)
		gelsolin_S3_like	250..344	CDD:200448	44/93 (47%)
		gelsolin_S4_like	388..488	CDD:200449	29/104 (28%)
		gelsolin_S5_like	509..598	CDD:200444	37/96 (39%)
		gelsolin_S6_like	613..710	CDD:200447	37/98 (38%)
		VHP	777..811	CDD:280388
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574416
Domainoid	1	1.000	68	1.000	Domainoid score	I9671
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	443	1.000	Inparanoid score	I1618
OMA	1	1.010	-	-		QHG55329
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	1	1.000	-	-		FOG0000527
OrthoInspector	1	1.000	-	-		otm24470
orthoMCL	1	0.900	-	-		OOG6_100298
Panther	1	1.100	-	-	O	PTHR11977
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X232
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.910