DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gel and scin

DIOPT Version :9

Sequence 1:	NP_524865.2	Gene:	Gel / 46008	FlyBaseID:	FBgn0010225	Length:	798	Species:	Drosophila melanogaster
Sequence 2:	NP_001038583.1	Gene:	scin / 566764	ZFINID:	ZDB-GENE-060503-6	Length:	733	Species:	Danio rerio

Alignment Length:	753	Identity:	269/753 - (35%)
Similarity:	407/753 - (54%)	Gaps:	73/753 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 HPSFANAGRTPGLEIWRIENFEPVIYPKTNYGKFYTGDSFIVLNTIENKKDKKLSWDVHFWLGLE 124
            |..|..||:..||:|||||..|.|..|::.||.|||||:::||:|:: :||... :|:|||||.|
Zfish     5 HKEFEKAGKYSGLQIWRIEKMEIVPVPESFYGSFYTGDAYLVLHTVK-QKDSSF-YDLHFWLGKE 67

  Fly   125 TSTDEAGAAAILTVQLDDLLNGGPVQHREVQDHESQLFLSYFKNGIRYEQGGVGTGFKHVETNAQ 189
            .|.||:.||||.:.|:||.|.|.|||:||:|..||.:|.||||.||:|:.|||.:||:||.||..
Zfish    68 CSQDESTAAAIFSTQMDDYLGGKPVQYREIQGFESTVFTSYFKGGIKYKSGGVASGFQHVITNDL 132

  Fly   190 GETRLFQVKGKRNVRVRQVNLSVSSMNTGDCFILDAGSDIYVYVGSQAKRVEKLKAISAANQIRD 254
            ...|||.:||:|.||..:|.||.:|.|.|||||:|.|..||.:.||:..:.|::||......|||
Zfish   133 TARRLFHIKGRRTVRATEVPLSWASFNNGDCFIVDLGPVIYQWCGSKCNKFERIKAAQVGTGIRD 197

  Fly   255 QDHNGRARVQIVDDFSTDADKQHFFDVLGSGSADQVPDESTADEDSAFERTDAAAVSLYKVSDAS 319
            .:.:|||::.::::....|:   ..:||  |...::| |....||:..:.::....|||.||||:
Zfish   198 NERSGRAKLVVIEEGQEPAE---MTEVL--GVKPEIP-EGDDSEDAVADVSNRKMASLYMVSDAT 256

  Fly   320 GKLKVDIIGQ-KPLTQAMLDTRECFILDTGSG--IFVWVGKGATQKEKTDAMAKAQEFLRTKKYP 381
            ||::|.::.: .|..|:.|.:.||||||.|..  ||||.|..|...|:.:||..|:.|::...||
Zfish   257 GKMQVSLVSKDNPFDQSNLLSDECFILDHGKNKMIFVWKGHNANPSERKEAMKTAESFIKQMGYP 321

  Fly   382 AWTQIHRIVEGSESAPFKQYFDTWRDAGMSHSRLIRSALGIG----SDEL--LNDDEIDSVVTQL 440
            ..|||..:.||.|:..|||:|.:|::..        .|.|:|    ::.:  :..::.|:  ::|
Zfish   322 QNTQIQVLPEGGETPIFKQFFKSWKEKD--------QAEGLGRVFVTERIAKIKQEKFDA--SKL 376

  Fly   441 KKSGGRAFGF-MPDHGQNVIET-ITQYVAKPGSDEIVVSTVPFDEKLPLLGFASYVLTYNYEANN 503
            .:|...|..: |.|.|....|. ..:..|..|..::.|....:.:   ..|...|::.|.|
Zfish   377 HESRQMAAQYNMVDDGAGKTEIWRVECGATKGDTKVPVDPETYGQ---FYGGDCYIILYRY---- 434

  Fly   504 GDTGSLTYVWHGVKA------SAAARKRAFEEGLVGSKDGLLVQTNQGHEPRHFYKIFKGKLLTS 562
             ..|.:.|.|.|.::      ::|......:..|.|  :.:.|:..||.||.|...:||.|.|..
Zfish   435 -SKGEIIYTWQGSRSTIDELTASAFLTVELDRSLGG--NAVQVRVTQGKEPPHLLSLFKDKPLIV 496

  Fly   563 F---------TALPVTAQLFRIRGTVESDVHASEVAADSSSLASSDAFVLHSGKSHKIYIWNGLG 618
            :         .|.....:||::|..:.:....|||.|.:|||.|:|.::|...:... |||.|.|
Zfish   497 YKDGTSRKGGQAPAAPTRLFQVRKNLGTITRISEVDAKASSLNSNDVYLLKLPQGDG-YIWKGKG 560

  Fly   619 ASAFEKQAAVDRFSDYWDDVELEQVEEGAEPDEFWEELNGEGQYDRSLGDDGAPLLES------- 676
            ||..|::||  ::.....:.:.:.|.||.|||.||..|.|:.:|..|      .||||
Zfish   561 ASEEEEKAA--KYMSEKLNCKTKMVVEGKEPDVFWMALGGKTEYQTS------GLLESRTIAHPP 617

  Fly   677 RLFHCHLSSGGFLKVEEV-AQYEQEDLDSDDIMLLDAGDEIYLWVGYGVSEEENGKLLDTAKLYF 740
            |||.|...:|.|: :||| .::.|:||..||:||||..|.:::|:|...:|.|..:.:.:||:|.
Zfish   618 RLFACSNKTGKFI-IEEVPGEFNQDDLAEDDVMLLDVWDSVFVWIGKDANEVERTESVKSAKIYI 681

  Fly   741 NLEPTARSFDTVSIIRVPQGKEPRVFKRMFPNWDDNYW 778
            ..:|:.|...|..:: |.||.||..|...|..||.:.|
Zfish   682 ETDPSGRDKGTPLVV-VKQGHEPPTFTGWFLAWDASRW 718

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gel	NP_524865.2	gelsolin_S1_like	63..176	CDD:200446	60/112 (54%)
		gelsolin_S2_like	191..283	CDD:200445	35/91 (38%)
		gelsolin_S3_like	307..404	CDD:200448	43/99 (43%)
		ADF_gelsolin	470..558	CDD:301701	21/93 (23%)
		ADF_gelsolin	569..661	CDD:301701	33/91 (36%)
		gelsolin_S6_like	675..774	CDD:200447	38/106 (36%)
scin	NP_001038583.1	gelsolin_S1_like	8..119	CDD:200446	60/112 (54%)
		gelsolin_S2_like	136..223	CDD:200445	36/91 (40%)
		gelsolin_S3_like	244..344	CDD:200448	43/99 (43%)
		gelsolin_S4_like	388..489	CDD:200449	24/110 (22%)
		gelsolin_S5_like	511..601	CDD:200444	33/92 (36%)
		gelsolin_S6_like	616..714	CDD:200447	36/99 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574412
Domainoid	1	1.000	94	1.000	Domainoid score	I7404
eggNOG	1	0.900	-	-		E1_KOG0443
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	443	1.000	Inparanoid score	I1618
OMA	1	1.010	-	-		QHG55329
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	1	1.000	-	-		FOG0000527
OrthoInspector	1	1.000	-	-		otm24470
orthoMCL	1	0.900	-	-		OOG6_100298
Panther	1	1.100	-	-	O	PTHR11977
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2540
SonicParanoid	1	1.000	-	-		X232
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.840