DRSC/TRiP Functional Genomics Resources

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Protein Alignment Gel and VILL

DIOPT Version :9

Sequence 1:NP_524865.2 Gene:Gel / 46008 FlyBaseID:FBgn0010225 Length:798 Species:Drosophila melanogaster
Sequence 2:NP_001371967.1 Gene:VILL / 50853 HGNCID:30906 Length:856 Species:Homo sapiens


Alignment Length:780 Identity:247/780 - (31%)
Similarity:373/780 - (47%) Gaps:99/780 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    67 GRTPGLEIWRIENFEPVIYPKTNYGKFYTGDSFIVLNTIEN-KKDKKLSWDVHFWLGLETSTDEA 130
            |...||.||..||.:.|..|:..||.|:....:::|:..:: |..:..|.|:|:|:|.:...:..
Human     9 GMQGGLHIWISENRKMVPVPEGAYGNFFEEHCYVILHVPQSPKATQGASSDLHYWVGKQAGAEAQ 73

  Fly   131 GAAAILTVQLDDLLNGGPVQHREVQDHESQLFLSYFKNGIRYEQGGVGTGFKHVETNAQGETRLF 195
            |||.....:|.|.|.|..|.|||.|.|||..|.|||:.||.|.:||:.:..||||||.....||.
Human    74 GAAEAFQQRLQDELGGQTVLHREAQGHESDCFCSYFRPGIIYRKGG
LASDLKHVETNLFNIQRLL 138

  Fly   196 QVKGKRNVRVRQVNLSVSSMNTGDCFILDAGSDIYVYVGSQAKRVEKLKAISAANQIRDQDH-NG 259
            .:||:::|...:|.||.:|.|.||.|:||.|..:..:.|.:....||.:.::....:||::. .|
Human   139 HIKGRKHVSATEVELSWNSFNKGDIFLLDLGKMMIQWNGPKTSISEKARGLALTYSLRDRERGGG 203

  Fly   260 RARVQIVDDFSTDADKQHFFD-VLGSGSADQVPDESTADEDSAFERTDAAAVSLYKVSDASGKLK 323
            ||::.:|||.:...|.....: |||.    :|.....|.......:...|.|.||.|.:....|.
Human   204 RAQIGVVDDEAKAPDLMQIMEAVLG
R----RVGSLRAATPSKDINQLQKANVRLYHVYEKGKDLV 264

  Fly   324 VDIIGQKPLTQAMLDTRECFILDTGS-GIFVWVGKGATQKEKTDAMAKAQEFLRTKKYPAWTQIH 387
            |..:...||||.:|...:.:|||.|. .|:||.|:.::.:|:..|.::|..|::.|.||.:|.:.
Human   265 VLELATPPLTQDLLQEEDFYILDQGGFKIYVWQGRMSSLQERKAAFSRAVGFIQAKGYPTYTNVE 329

  Fly   388 RIVEGSESAPFKQYFDTWRDAGMSHSRLIRSALGIGSDELLNDDEIDSVVTQLKKSGGRAFGFMP 452
            .:.:|:|||.|||.|.||     |..|.....|| |.|:.::          :|...|:.     
Human   330 VVNDGAESAAFKQLFRTW-----SEKRRRNQKLG-GRDKSIH----------VKLDVGKL----- 373

  Fly   453 DHGQNVIETITQYVAKPGSDEIVVSTV------PFDEKL--PLLGFASYVLTYNYEANNGDTGSL 509
             |.|..:....:.| ..||.::.|..:      |.|.|.  .|.....|::.|.|: ..|....:
Human   374 -HTQPKLAAQLRMV-DDGSGKVEVWCIQDLHRQPVDPKRHGQLCAGNCYLVLYTYQ-RLGRVQYI 435

  Fly   510 TYVWHGVKASA----AARKRAFE-EGLVGSKDGLLVQ--TNQGHEPRHFYKIFKGKLL------- 560
            .|:|.|.:|:|    |....|.| :.:.|   |:|||  ...|.||.||..||:|:|:       
Human   436 LYLWQGHQATADEIEALNSNAEELDVMYG---GVLVQEHVTMGSEPPHFLAIFQGQLVIFQERAG 497

  Fly   561 -----TSFTALPVTAQLFRIRGTVESDVHASEVAADSSSLASSDAFVLHSGKSHKIYIWNGLGAS 620
                 .|.:    |.:||:::||...:....||.|.:|||.|||.|:|.:  :...|:|.|.|.:
Human   498 HHGKGQSAS----TTRLFQVQGTDSHNTRTMEVPARASSLNSSDIFLLVT--ASVCYLWFGKGCN 556

  Fly   621 AFEKQAA------VDRFSDYWDDVELEQVEEGAEPDEFWEELNGEGQY--DRSLGDDGAPLLESR 677
            ..:::.|      :.|.::       |.|.||.||..|||.|.|...|  ::.|.:: .|..:.|
Human   557 GDQREMARVVVTVISRKNE-------ETVLEGQEPPHFWEALGGRAPYPSNKRLPEE-VPSFQPR 613

  Fly   678 LFHCHLSSGGFLKVEEVAQYEQEDLDSDDIMLLDAGDEIYLWVGYGVSEEENGKLLDTAKLYFNL 742
            ||.|. |..|.|.:.||..:.|||||..||||||...||:||:|...||.:  :.:...:.|...
Human   614 LFECS-SHMGCLVLAEVGFFSQEDLDKYDIMLLDTWQEIFLWLGEAASEWK--EAVAWGQEYLKT 675

  Fly   743 EPTARSFDTVSIIRVPQGKEPRVFKRMFPNWDDNYWQNQPSYED-----------MKQLVIDANN 796
            .|..|| ....|:.|.||.||..|...|..||...|.:.||:::           :.::..:.||
Human   676 HPAGRS-PATPIVLVKQGHEPPTFIGWFFTWDPYKWTSHPSHKEVVDGSPAAASTISEITAEVNN 739

  Fly   797  796
            Human   740  739

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GelNP_524865.2 gelsolin_S1_like 63..176 CDD:200446 41/109 (38%)
gelsolin_S2_like 191..283 CDD:200445 29/93 (31%)
gelsolin_S3_like 307..404 CDD:200448 36/97 (37%)
ADF_gelsolin 470..558 CDD:301701 31/102 (30%)
ADF_gelsolin 569..661 CDD:301701 33/97 (34%)
gelsolin_S6_like 675..774 CDD:200447 39/98 (40%)
VILLNP_001371967.1 gelsolin_S1_like 6..119 CDD:200446 41/109 (38%)
Gelsolin-like 1 22..74 12/51 (24%)
gelsolin_S2_like 135..228 CDD:200445 29/92 (32%)
Gelsolin-like 2 146..186 14/39 (36%)
gelsolin_S3_like 248..346 CDD:200448 36/97 (37%)
Gelsolin-like 3 263..307 16/43 (37%)
gelsolin_S4_like 385..485 CDD:200449 30/104 (29%)
Gelsolin-like 4 401..450 13/49 (27%)
gelsolin_S5_like 506..596 CDD:200444 33/102 (32%)
Gelsolin-like 5 521..561 15/41 (37%)
gelsolin_S6_like 611..706 CDD:200447 39/98 (40%)
Gelsolin-like 6 624..665 21/42 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 762..796
VHP 821..856 CDD:128458
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165141464
Domainoid 1 1.000 69 1.000 Domainoid score I9624
eggNOG 1 0.900 - - E1_KOG0443
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG55329
OrthoDB 1 1.010 - - D1376537at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm41645
orthoMCL 1 0.900 - - OOG6_100298
Panther 1 1.100 - - LDO PTHR11977
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X232
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1110.720

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