DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gel and scinlb

DIOPT Version :9

Sequence 1:	NP_524865.2	Gene:	Gel / 46008	FlyBaseID:	FBgn0010225	Length:	798	Species:	Drosophila melanogaster
Sequence 2:	NP_998255.2	Gene:	scinlb / 406363	ZFINID:	ZDB-GENE-040426-2068	Length:	720	Species:	Danio rerio

Alignment Length:	753	Identity:	274/753 - (36%)
Similarity:	384/753 - (50%)	Gaps:	78/753 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 VMHPSFANAGRTPGLEIWRIENFEPVIYPKTNYGKFYTGDSFIVLNTIENKKDKKLSWDVHFWLG 122
            |.|..|..||:..||::|||||.:....||..:|.|:|||::|:|:|....     |:.:|.|||
Zfish     2 VSHKEFTTAGKVSGLQVWRIENMDLKPVPKNLHGSFFTGDAYILLHTTSAP-----SYSIHMWLG 61

  Fly   123 LETSTDEAGAAAILTVQLDDLLNGGPVQHREVQDHESQLFLSYFKNGIRYEQGGVGTGFKHVETN 187
            .|.|.||:|||||.:.||||.|.|.|||.||||::||..||.|||:||:|.||||.:||.||.||
Zfish    62 NECSQDESGAAAIFSTQLDDFLGGSPVQFREVQNNESLTFLGYFKSGIKYMQGGVASGFHHVSTN 126

  Fly   188 AQGETRLFQVKGKRNVRVRQVNLSVSSMNTGDCFILDAGSDIYVYVGSQAKRVEKLKAISAANQI 252
            .....||..:||:|.:|..:|.:|.:|.|.|||||:|.|.|||.:.||...|.|:|||...|..|
Zfish   127 DVNVKRLLHIKGRRVIRATEVAMSWASFNKGDCFIVDLGKDIYQWCGSGCNRFERLKASKLAIDI 191

  Fly   253 RDQDHNGRARVQIVDDFSTDADKQHFFDVLGSGS--ADQVPDESTADEDSAFERTDAAAVSLYKV 315
            ||.:.||||::.:|::   ||:.......||..|  |...||      |...|.::.....||.:
Zfish   192 RDNERNGRAKLVMVEE---DAEPDALIQALGPKSEIAPATPD------DEQVEISNKNKGKLYMI 247

  Fly   316 SDASGKLKVDIIGQK-PLTQAMLDTRECFILDTG--SGIFVWVGKGATQKEKTDAMAKAQEFLRT 377
            |||||.:|...:.:| |..|.||...||:|||.|  :.:|||.|..||..|:..||:.|::|::.
Zfish   248 SDASGSMKTTEVAEKSPFKQEMLINTECYILDNGVDNNVFVWKGSKATTSERKAAMSAAEQFIKE 312

  Fly   378 KKYPAWTQIHRIVEGSESAPFKQYFDTWRDAGMSHSRLIRSALGIGSDELLNDDEIDSVVTQLKK 442
            |.|...|.|..:.||.|:..|||:|..|:|...:........:|    ::.|.::|....:.|..
Zfish   313 KNYSKKTMIQVLPEGGETTLFKQFFSDWKDKYQTTGPTKAYTIG----KIANVEQIPFDASSLHD 373

  Fly   443 SGGRAFGF-MPDHGQNVIETITQYVAKPGSDEIVVSTVPFDEKL--PLLGFASYVLTYNYEANNG 504
            :...|... |.|.|...:|.   :..:.|      :.||.|.|.  ...|...|::.|.|:....
Zfish   374 NKTMAAQHNMVDDGSGKVEI---WRVEEG------ARVPVDPKTYGQFFGGDCYLILYTYKKETK 429

  Fly   505 DTGSLTYVWHGVK------ASAAARKRAFEEGLVGSKDGLLVQTNQGHEPRHFYKIFKGKLLTSF 563
            |. .:.|.|.|:|      |::|......::.:.|:.  :.|:..|||||.|...:||||.:...
Zfish   430 DQ-YIIYTWQGLKCTQDELAASAFLTVQLDDSMGGAP--VQVRVTQGHEPPHLMSLFKGKPMIIH 491

  Fly   564 T---------ALPVTAQLFRIRGTVESDVHASEVAADSSSLASSDAFVLHSGKSHKIYIWNGLGA 619
            .         ..|...:||.||.:......|.||...::||.::|.|||.:  |..:::|.|.||
Zfish   492 AGGTSRKDGQTKPAATRLFHIRQSTSKATRAVEVEPSAASLNTNDVFVLKT--SGGVFVWKGAGA 554

  Fly   620 SAFEKQAAVDRFSDYWDDV---ELEQVEEGAEPDEFWEELNGEGQYDRSLGDDGAPLLE-----S 676
            |..|..||     .|...|   :...|.||.||:.||..|.|:..|.:|      |.|:     :
Zfish   555 SDEEMAAA-----KYVVSVLGGQSTDVPEGKEPESFWAALGGKKDYQKS------PALQRTIKPA 608

  Fly   677 RLFHCHLSSGGFLKVEEV-AQYEQEDLDSDDIMLLDAGDEIYLWVGYGVSEEENGKLLDTAKLYF 740
            |||.|. :..|.|.|||| ..:.|.||.:||:||||..|:|:||:|...:|.|.......||.|.
Zfish   609 RLFGCS-NKTGRLVVEEVPGDFTQSDLATDDVMLLDTWDQIFLWIGNEANEVEKTGSPKIAKDYV 672

  Fly   741 NLEPTARSFDTVSIIRVPQGKEPRVFKRMFPNWDDNYW 778
            ..:|..|.  .::|..:.||.||..|...|..|:.|.|
Zfish   673 ESDPAGRC--GLAITTIKQGSEPPTFTGWFHAWNANLW 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gel	NP_524865.2	gelsolin_S1_like	63..176	CDD:200446	58/112 (52%)
		gelsolin_S2_like	191..283	CDD:200445	38/91 (42%)
		gelsolin_S3_like	307..404	CDD:200448	41/99 (41%)
		ADF_gelsolin	470..558	CDD:301701	26/95 (27%)
		ADF_gelsolin	569..661	CDD:301701	33/94 (35%)
		gelsolin_S6_like	675..774	CDD:200447	38/104 (37%)
scinlb	NP_998255.2	gelsolin_S1_like	7..115	CDD:200446	58/112 (52%)
		gelsolin_S2_like	130..219	CDD:200445	38/91 (42%)
		gelsolin_S3_like	239..339	CDD:200448	41/99 (41%)
		gelsolin_S4_like	383..483	CDD:200449	28/111 (25%)
		gelsolin_S5_like	505..594	CDD:200444	33/95 (35%)
		gelsolin_S6_like	607..704	CDD:200447	38/99 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574413
Domainoid	1	1.000	94	1.000	Domainoid score	I7404
eggNOG	1	0.900	-	-		E1_KOG0443
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	443	1.000	Inparanoid score	I1618
OMA	1	1.010	-	-		QHG55329
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	1	1.000	-	-		FOG0000527
OrthoInspector	1	1.000	-	-		otm24470
orthoMCL	1	0.900	-	-		OOG6_100298
Panther	1	1.100	-	-	O	PTHR11977
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X232
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.810