Protein Alignment Gel and Svil

DIOPT Version :10

• Sequence 1: NP_524865.2
• Gene: Gel / 46008
• FlyBaseID: FBgn0010225
• Length: 798
• Species: Drosophila melanogaster
• Sequence 2: XP_006254092.1
• Gene: Svil / 361256
• RGDID: 1306354
• Length: 2208
• Species: Rattus norvegicus
• Alignment Length: 983
• Identity: 217/983 - (22%)
• Similarity: 367/983 - (37%)
• Gaps: 259/983 - (26%)

  Fly    12 LSSLLVFLALSSSLCSAGTLNARPAFPVQSGEIQPSGQ-----------------NSKQAARRVM 59
            |:|......:||.|||........:.|::..|.:|..|                 |:|.|.   |
  Rat  1217 LASPTAITPISSPLCSKSRGTTPVSKPLEDIEARPDMQLESDLKLDRLETFLRRLNNKVAG---M 1278

  Fly    60 HPSFANAGRTPGLEIWRIENFEPVIYPKTNYGKFYTG-DSFIVLNTIENKKDKKLSWDVHF--WL 121
            ..:..........|:.::::.|       .:.|||.. |..:..:.:|.::|    :||.|  :.
  Rat  1279 QETVLTVTGKSVKEVMKLDDDE-------TFAKFYRSVDHSLPRSPVELEED----FDVIFDPYA 1332

  Fly   122 GLETSTDEAGAAAI--------------LTVQLDDLLNGGPVQHREVQDHESQLFLSYFKNGIRY 172
            ...||.......::              |....||||.....|...|...||:        .::.
  Rat  1333 PKLTSLVAEHKRSVRPKRRVQASKNPLKLLAARDDLLQEYTEQRLNVAFMESK--------RMKV 1389

  Fly   173 EQGGVGTGFKHV----------------------ETNAQG------ETRLFQVKGKRNVRVRQVN 209
            |:....:.|..|                      |.|:..      :..|.|:||:|:|:.|.|.
  Rat  1390 EKMSSNSNFSEVTLAGLASRENFSSISLRSVNLMEQNSNNSALPYKKLMLLQIKGRRHVQTRLVE 1454

  Fly   210 LSVSSMNTGDCFILDAGSDIYVYVGSQAKRVEKLKAISAANQIRDQDHNG-RAR-VQIVDD---F 269
            ...||:|:||||:|.:....:::||..:..:||.||...|..|:.:...| ||. ||.:::   .
  Rat  1455 PRASSLNSGDCFLLLSPQYCFLWVGEFSNVIEKAKASELATLIQTKRELGCRATYVQTIEEGINT 1519

  Fly   270 STDADKQHFFDVLGSGSADQVPDESTAD--EDSAFERTDAAAVSLYKVSDASGKLKVDIIGQKPL 332
            .|.|.|. |:.:||.    |...:|..|  ||..:|........:|:::|.......|..|:.|.
  Rat  1520 HTHAAKD-FWKLLGG----QTSYQSAGDPKEDELYETAIIETNCVYRLTDDKLVPDDDYWGKIPK 1579

  Fly   333 TQAMLDTRECFILDTGSGIFVWVGKGATQKEKTDAMAKAQEFLR-TKKY---------------- 380
            . ::|.::|..:.|.||.::||.||..|..::..|...|:.... |..|
  Rat  1580 C-SLLQSKEVLVFDFGSEVYVWHGKEVTLAQRKIAFQLAKHLWNGTFDYENCDINPLDPGECNPL 1643

  Fly   381 --------PAWTQIHRIVEGSESAPFKQYFDTWRDAGMSHSRLIRSALGIGSDELLND------- 430
                    |.|....|:.|.:|:..||:.|..|.:        ::......|.|:::.
  Rat  1644 IPRKGQGRPDWAIFGRVTEHNETILFKEKFLDWTE--------LKRPTEKNSGEVVHQKDYPRAD 1700

  Fly   431 ----DEIDSVVT-QLKKSG-------GRAFGFMPDHGQNVIETITQYVAKPGSDEIVVSTVPFD- 482
                |....|.| |:..|.       ||.:|.:....:..:|..|..|.       |...:.||
  Rat  1701 VKPYDVTRMVATPQMTASTILDGVNVGRGYGLVEGDDRRQVEITTVSVD-------VWHILEFDY 1758

  Fly   483 EKLPLLGFA------SYVLTYNYEANN---------------GDTGSLTYVWHGVKASAAARKRA 526
            .:||.....      :||:.:.|.|:.               |....:.:.|.|..::.:
  Rat  1759 SRLPRQSIGQFHEGDAYVVKWKYMASTAVGSRQKGEHPVRVAGKEKCVYFFWQGRHSTVS----- 1818

  Fly   527 FEEGL-------VGSKDGLLVQTNQGHEPRHFYKIFKGKLLT-------SFTALPVTAQLFRIRG 577
             |:|.       :..:.|..||..||.||..|.:.|:|.::.       ....:....:|:.:||
  Rat  1819 -EKGTSALMTVELDEERGAQVQVLQGKEPPCFLQCFQGGMVVHSGRREEEEENVQSEWRLYCVRG 1882

  Fly   578 TVESDVHASEVAADSSSLASSDAFVLHSGKSHKIYIWNGLGASAFEKQ---AAVDRFSDYW---- 635
            .|..:.:..|||...|||.|..:.|:.:.....||:|:|..|....|:   .|.::..:..
  Rat  1883 EVPMEGNLLEVACHCSSLRSRTSMVVLNINKALIYLWHGCKAQGHTKEVGRTAANKIKEECPLEA 1947

  Fly   636 -----DDVELEQVEEGAEPDEFWEELNGEGQ--YDRSLGDDGAPLLESRLFHCHLSSGGFLKVEE 693
                 .:|.:.:.:||:||..||:.|....:  ||..|.|.|:.....|||....|||.|...|.
  Rat  1948 GLHSSSNVTIHECDEGSEPLGFWDALGRRDRKAYDCMLQDPGSFNFAPRLFILSSSSGDFSATEF 2012

  Fly   694 V-----------AQYEQEDLDS---DDIMLLDAGDEIYLWVGYGVSEEENGKLLDTAKLYF---- 740
            |           ..:.||||.|   ..:.|:|...|:|||.|:..:|   .|:..:|::.:
  Rat  2013 VYPARAPSAVSSMPFLQEDLYSAPQPALFLVDNHHEVYLWQGWWPTE---NKITGSARIRWASDR 2074

  Fly   741 --------------NLE-PTARSFDTVSIIRVPQGKEPRVFKRMFPNWDDNYWQNQPSYEDMKQL 790
                          ||: |..:|:      .:..|.||..|..|||:     |:::....::.::
  Rat  2075 KSAMETVLQYCRGKNLKRPPPKSY------LIHAGLEPLTFTNMFPS-----WEHREDIAEITEM 2128

  Fly   791 VIDANNEV 798
            ..:.:|::
  Rat  2129 DTEVSNQI 2136

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gel	NP_524865.2	gelsolin_S1_like	63..176	CDD:200446	23/129 (18%)
		gelsolin_S2_like	191..283	CDD:200445	33/96 (34%)
		gelsolin_S3_like	307..404	CDD:200448	27/121 (22%)
		ADF_gelsolin	470..558	CDD:472830	23/116 (20%)
		ADF_gelsolin	569..661	CDD:472830	27/103 (26%)
		gelsolin_S6_like	675..774	CDD:200447	35/131 (27%)
Svil	XP_006254092.1	gelsolin_S2_like	1436..1532	CDD:200445	33/96 (34%)
		gelsolin_like	1557..1657	CDD:200436	21/100 (21%)
		gelsolin_S4_like	1740..1853	CDD:200449	25/125 (20%)
		gelsolin_S5_like	1873..1978	CDD:200444	27/104 (26%)
		ADF_gelsolin	1995..2117	CDD:472830	35/135 (26%)
		VHP	2173..2208	CDD:460493