DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gel and gsnb

DIOPT Version :9

Sequence 1:	NP_524865.2	Gene:	Gel / 46008	FlyBaseID:	FBgn0010225	Length:	798	Species:	Drosophila melanogaster
Sequence 2:	NP_001082813.1	Gene:	gsnb / 336623	ZFINID:	ZDB-GENE-030131-8567	Length:	728	Species:	Danio rerio

Alignment Length:	771	Identity:	282/771 - (36%)
Similarity:	405/771 - (52%)	Gaps:	84/771 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 VMHPSFANAGRTPGLEIWRIENFEPVIYPKTNYGKFYTGDSFIVLNTIENKKDKKLSWDVHFWLG 122
            |.||.|..||:..||::|||||.:.|..||..||.|||||:::|||||: :....|.:|:|||:|
Zfish     2 VHHPEFEKAGKQTGLQVWRIENLDLVPVPKNLYGGFYTGDTYLVLNTIK-QNSGNLQYDLHFWIG 65

  Fly   123 LETSTDEAGAAAILTVQLDDLLNGGPVQHREVQDHESQLFLSYFKNGIRYEQGGVGTGFKHVETN 187
            ...:.||:|||||.|||:||.|.|.|:|:||||..||:.||.|||:||:|.||||.:||||. :.
Zfish    66 EACTVDESGAAAIFTVQMDDFLGGKPIQYREVQGFESKTFLGYFKSGIKYMQGGVASGFKHT-SG 129

  Fly   188 AQGETRLFQVKGKRNVRVRQVNLSVSSMNTGDCFILDAGSDIYVYVGSQAKRVEKLKAISAANQI 252
            |....||..|.|:|.||..:|.:|.:|.|.||||||:.|.:||.:.||:..:.|:|||.|.:..|
Zfish   130 AVNVKRLLHVSGRRVVRATEVPMSWASFNQGDCFILNLGQEIYQWCGSKCNQFERLKATSISKDI 194

  Fly   253 RDQDHNGRARVQIVDDFSTDADKQHFFDVLGSGSADQVPDESTADEDSAFERTDAA---AVSLYK 314
            ||.:..|||::.:.:: .::.||  ...:||       |.....|..|...:|||:   :..|||
Zfish   195 RDNECCGRAKLFVCEE-GSENDK--ILAILG-------PKPDLPDAQSEDTKTDASNRKSAKLYK 249

  Fly   315 VSDASGKLKVDIIGQ-KPLTQAMLDTRECFILDTGSG--IFVWVGKGATQKEKTDAMAKAQEFLR 376
            ||:|||.:.|.::.: .|.:|:.|.:.:|||||.|:.  ||||.||.|.::|::..|..|::|:.
Zfish   250 VSNASGSMSVSLVSEDNPFSQSDLQSADCFILDHGTNGKIFVWKGKEANKEERSAGMKAAEDFIS 314

  Fly   377 TKKYPAWTQIHRIVEGSESAPFKQYFDTWRDAGMSHSRLIRSALGIG----SDELLNDDEIDSVV 437
            ...||..|::..|.|..|:..|||:|..|||...|.        |:|    |:::....::....
Zfish   315 QMGYPKHTEVQIIPENGETPLFKQFFKFWRDTDQSK--------GMGQAYVSNKIAKIKKVPFDA 371

  Fly   438 TQLKKSGGRA--FGFMPD-HGQNVIETITQYVAKPGSDEIVVSTVPFDEKL--PLLGFASYVLTY 497
            :.|.||...|  .|.:.| .|...|..|      .|||:     ||.|..:  ...|..||::.|
Zfish   372 SSLHKSEAMAAQHGMVDDGKGDKKIWRI------EGSDK-----VPVDPSIYGQFYGGDSYIILY 425

  Fly   498 NYEANNGDTGSLTYVWHG------VKASAAARKRAFEEGLVGSKDGLLVQTNQGHEPRHFYKIFK 556
            .|: ::|..|.:.|:|.|      .|.::|......:..|.||  .:.|:..||.||.....||.
Zfish   426 TYK-HSGRQGQIIYMWQGEESSQDEKGASAILAAQLDAELGGS--AVQVRVIQGKEPLQLMSIFG 487

  Fly   557 GKLLTSF---------TALPVTAQLFRIRGTVESDVHASEVAADSSSLASSDAFVL--HSGKSHK 610
            ||.:..:         .:.....:||::|........|.||...:|||.|:|||||  .||.:
Zfish   488 GKPMVVYMGGTSRKGGQSKASEIRLFQVRANPAGHTRAVEVDPVASSLNSNDAFVLVTPSGST-- 550

  Fly   611 IYIWNGLGASAFEKQAAVDRFSDYWDDVELEQVEEGAEPDEFWEELNGEGQYD-----RSLGDDG 670
              :|.|.|.|..||..|....|..  .|.|.::.||||.|.||..|.|:.:|.     ::..|..
Zfish   551 --LWLGQGTSDAEKNGAAKLGSIL--GVTLSEISEGAEGDVFWTALGGKAEYRTSERLKNKMDSH 611

  Fly   671 APLLESRLFHCHLSSGGFLKVEEV-AQYEQEDLDSDDIMLLDAGDEIYLWVGYGVSEEENGKLLD 734
            .|    |||.|...:|..| :||| .:..||||..||:|:||..|::::|:|...:|:|..:.|.
Zfish   612 PP----RLFACSNKTGQLL-IEEVPGEMTQEDLAPDDVMILDTWDQVFVWIGNEANEDEKSEALT 671

  Fly   735 TAKLYFNLEPTARSFDTVSIIRVPQGKEPRVFKRMFPNWDDNYWQNQPSYEDMKQL 790
            .|..|...:|..|...| .|:.|.||.|...|...|..||.::|.:.|.:..|..|
Zfish   672 LAAKYIESDPAGRDKRT-PIVTVKQGFELPTFTGWFLGWDHDFWSSDPLHRAMAGL 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gel	NP_524865.2	gelsolin_S1_like	63..176	CDD:200446	62/112 (55%)
		gelsolin_S2_like	191..283	CDD:200445	35/91 (38%)
		gelsolin_S3_like	307..404	CDD:200448	40/102 (39%)
		ADF_gelsolin	470..558	CDD:301701	28/95 (29%)
		ADF_gelsolin	569..661	CDD:301701	36/93 (39%)
		gelsolin_S6_like	675..774	CDD:200447	36/99 (36%)
gsnb	NP_001082813.1	gelsolin_S1_like	7..119	CDD:200446	62/112 (55%)
		gelsolin_S2_like	133..216	CDD:200445	33/83 (40%)
		gelsolin_S3_like	245..341	CDD:200448	38/95 (40%)
		gelsolin_S4_like	386..486	CDD:200449	30/113 (27%)
		gelsolin_S5_like	508..597	CDD:200444	36/94 (38%)
		gelsolin_S6_like	612..710	CDD:200447	37/103 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574410
Domainoid	1	1.000	94	1.000	Domainoid score	I7404
eggNOG	1	0.900	-	-		E1_KOG0443
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H121987
Inparanoid	1	1.050	443	1.000	Inparanoid score	I1618
OMA	1	1.010	-	-		QHG55329
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	1	1.000	-	-		FOG0000527
OrthoInspector	1	1.000	-	-		otm24470
orthoMCL	1	0.900	-	-		OOG6_100298
Panther	1	1.100	-	-	O	PTHR11977
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X232
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.810