DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gel and scinla

DIOPT Version :9

Sequence 1:	NP_524865.2	Gene:	Gel / 46008	FlyBaseID:	FBgn0010225	Length:	798	Species:	Drosophila melanogaster
Sequence 2:	NP_835232.2	Gene:	scinla / 323285	ZFINID:	ZDB-GENE-030131-2005	Length:	720	Species:	Danio rerio

Alignment Length:	752	Identity:	271/752 - (36%)
Similarity:	380/752 - (50%)	Gaps:	68/752 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 VMHPSFANAGRTPGLEIWRIENFEPVIYPKTNYGKFYTGDSFIVLNTIENKKDKKLSWDVHFWLG 122
            |.|..|.|||:.|||:|||||..:..:.||..:|.|:|||:::||.|     ....|::||.|||
Zfish     2 VFHKEFQNAGKEPGLQIWRIEKMDLKLVPKQLHGNFFTGDAYVVLFT-----SPAPSYNVHMWLG 61

  Fly   123 LETSTDEAGAAAILTVQLDDLLNGGPVQHREVQDHESQLFLSYFKNGIRYEQGGVGTGFKHVETN 187
            .|.|.||:|||||..:||||.|.|.|||:||||::||..||.|||.||:|:||||.:||.||.:|
Zfish    62 NECSQDESGAAAIFAMQLDDHLGGAPVQYREVQNNESVTFLGYFKTGIKYKQGGVSSGFNHVVSN 126

  Fly   188 AQGETRLFQVKGKRNVRVRQVNLSVSSMNTGDCFILDAGSDIYVYVGSQAKRVEKLKAISAANQI 252
            .....|:..:||:|.:|..:||:|.:|.|.|||||||.|.|||.:.||:..|.|:|||...:..|
Zfish   127 EMNTKRVLHIKGRRAIRATEVNMSWASFNHGDCFILDLGKDIYQWCGSKCNRFERLKASEVSIGI 191

  Fly   253 RDQDHNGRARVQIVDDFSTDADKQHFFDVLGSGSADQVPDESTADEDSAFERTDAAAVSLYKVSD 317
            ||.:.||||.:.||:|.|   :...|.:.|  |....:|:.|..||.:  :|.:....||:.|||
Zfish   192 RDNERNGRATLHIVEDGS---EPDVFSNTL--GPKPSIPEGSPDDETT--DRNNQKKASLHMVSD 249

  Fly   318 ASGKLKVDIIGQ-KPLTQAMLDTRECFILDTG--SGIFVWVGKGATQKEKTDAMAKAQEFLRTKK 379
            |:|.:|...:.| .|..|.:|:..:|:|||.|  |.||||.|..|..:|:..||..|::|::.|.
Zfish   250 AAGSMKTSEVKQNSPFKQELLNPSDCYILDNGLDSKIFVWKGPRANTEERKSAMKVAEQFIKEKN 314

  Fly   380 YPAWTQIHRIVEGSESAPFKQYFDTWRDAGMSHSRLIRSALGIGSDELLNDDEIDSVVTQLKKSG 444
            ||..|||..:..|.|:..|||:|..|:|...|...  ..|..||....::....|:......|..
Zfish   315 YPKNTQIQVMPGGGETTLFKQFFSNWKDKDQSTGP--GQAYSIGRIARVSQVPFDASSLHSNKVM 377

  Fly   445 GRAFGFMPDHGQNVIETITQYVAKPGSDEIVVSTVPFDEKLPLLGFASYVLTYNYEANNGDTGSL 509
            ....|.:.|....|     |.....|:|.:.|....|.:   ..|...|::.|.| .|.|....:
Zfish   378 AAQHGMVDDGSGKV-----QVWRVEGNDRVPVDPSSFGQ---FFGGDCYLILYTY-LNGGREQHI 433

  Fly   510 TYVWHGVK-------ASAAARKRAFEEGLVGSKDGLLVQTNQGHEPRHFYKIFKGKLLTSFTALP 567
            .|.|.|:|       |||....: .::.:.|:.  :.|:..||.||.|...:||||        |
Zfish   434 IYTWQGLKCTQDELTASAFLTVK-LDDSMGGAP--VQVRVTQGQEPAHLMSLFKGK--------P 487

  Fly   568 V-----------------TAQLFRIRGTVESDVHASEVAADSSSLASSDAFVLHSGKSHKIYIWN 615
            :                 |.:||.||.:......|.||...:|.|.::|.|||...:.  :::|.
Zfish   488 MIIHLGGTSRKGGQSRVGTTRLFHIRQSSTRATRAVEVEPCASKLNTNDVFVLKFPEG--MFLWK 550

  Fly   616 GLGASAFEKQAAVDRFSDYWDDVELEQVEEGAEPDEFWEELNGEGQYDRSLGDDGAPLLESRLFH 680
            |:|||  |::.|..::..........::.||.||..||..|.|:..|..|........| .|||.
Zfish   551 GVGAS--EEEIAAAKYVCSILGGSATEISEGKEPAAFWSSLGGKKDYQTSKNLQKTVKL-PRLFG 612

  Fly   681 CHLSSGGFLKVEEVAQYEQEDLDSDDIMLLDAGDEIYLWVGYGVSEEENGKLLDTAKLYFNLEPT 745
            |...:|..:..|......|.||.:||:||||..|:|:||:|...:.||.......||.|.:.:|:
Zfish   613 CSNKTGRLIAEEVPGDLTQSDLATDDVMLLDTWDQIFLWIGNDANVEEKIGSAKIAKDYVDSDPS 677

  Fly   746 ARSFDTVSIIRVPQGKEPRVFKRMFPNWDDNYWQNQP 782
            .|  ..:.||.:.||.||..|...|..||...|...|
Zfish   678 KR--QGIPIITIKQGFEPPSFTGWFQAWDSKMWDTDP 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gel	NP_524865.2	gelsolin_S1_like	63..176	CDD:200446	61/112 (54%)
		gelsolin_S2_like	191..283	CDD:200445	40/91 (44%)
		gelsolin_S3_like	307..404	CDD:200448	41/99 (41%)
		ADF_gelsolin	470..558	CDD:301701	26/94 (28%)
		ADF_gelsolin	569..661	CDD:301701	29/91 (32%)
		gelsolin_S6_like	675..774	CDD:200447	35/98 (36%)
scinla	NP_835232.2	gelsolin_S1_like	7..115	CDD:200446	61/112 (54%)
		gelsolin_S2_like	131..212	CDD:200445	39/83 (47%)
		gelsolin_S3_like	239..339	CDD:200448	41/99 (41%)
		gelsolin_S4_like	383..483	CDD:200449	27/111 (24%)
		gelsolin_S5_like	506..594	CDD:200444	29/91 (32%)
		gelsolin_S6_like	608..704	CDD:200447	35/97 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574414
Domainoid	1	1.000	70	1.000	Domainoid score	I9475
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	443	1.000	Inparanoid score	I1618
OMA	1	1.010	-	-		QHG55329
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	1	1.000	-	-		FOG0000527
OrthoInspector	1	1.000	-	-		otm24470
orthoMCL	1	0.900	-	-		OOG6_100298
Panther	1	1.100	-	-	O	PTHR11977
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2540
SonicParanoid	1	1.000	-	-		X232
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.940