DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gel and gsna

DIOPT Version :9

Sequence 1:	NP_524865.2	Gene:	Gel / 46008	FlyBaseID:	FBgn0010225	Length:	798	Species:	Drosophila melanogaster
Sequence 2:	XP_021324427.1	Gene:	gsna / 321099	ZFINID:	ZDB-GENE-030131-9653	Length:	738	Species:	Danio rerio

Alignment Length:	773	Identity:	286/773 - (36%)
Similarity:	417/773 - (53%)	Gaps:	74/773 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 VMHPSFANAGRTPGLEIWRIENFEPVIYPKTNYGKFYTGDSFIVLNTIENKKDKKLSWDVHFWLG 122
            |.||.|..||:.|||::||||.|:.|..|:..||.|||||:::||.|.: :....|.:|:|||||
Zfish     2 VYHPEFERAGKEPGLQVWRIEKFDLVAVPENLYGGFYTGDAYLVLKTTK-QTSGNLQYDLHFWLG 65

  Fly   123 LETSTDEAGAAAILTVQLDDLLNGGPVQHREVQDHESQLFLSYFKNGIRYEQGGVGTGFKHVETN 187
            ...:.||:|:|||.|||:||.|.|.|:|:||||.|||:.||.|||.|::|.||||.:|||||.||
Zfish    66 DYCTQDESGSAAIFTVQMDDYLGGKPIQYREVQGHESKAFLGYFKKGLQYMQGGVASGFKHVVTN 130

  Fly   188 AQGETRLFQVKGKRNVRVRQVNLSVSSMNTGDCFILDAGSDIYVYVGSQAKRVEKLKAISAANQI 252
            .....|:.||||:|.||..:|.:|..|.|.|||||||.|::||.:.||::.|.|||||...|..|
Zfish   131 EVVMQRVLQVKGRRVVRATEVPVSWDSFNQGDCFILDLGNEIYQWCGSKSNRFEKLKATQLAKGI 195

  Fly   253 RDQDHNGRARVQIVDDFSTDADKQHFFDVLGSGSADQVPD--ESTADEDSAFERTDAAAVSLYKV 315
            ||.:.:|||||.:.|:   ..:::...:|||     :.||  |..:|:..| :.::.....||||
Zfish   196 RDNERSGRARVYVCDE---GVEREKMLEVLG-----EKPDLPEGASDDVKA-DASNRKMAKLYKV 251

  Fly   316 SDASGKLKVDII-GQKPLTQAMLDTRECFILDTGSG--IFVWVGKGATQKEKTDAMAKAQEFLRT 377
            |||||.:.:.:: .:.|.||:.|::.:|||||.||.  ||||.||.|..:|:..||..|.||::.
Zfish   252 SDASGDMAIALVAAENPFTQSALESSDCFILDHGSDGKIFVWKGKDANMEERKAAMKAADEFIKK 316

  Fly   378 KKYPAWTQIHRIVEGSESAPFKQYFDTWRDAGMSHSRLIRSALGIG--SDELLNDDEIDSVVTQL 440
            ..||..||:..:.|..|:..|||:|..|||...:      ..:|:.  |:.:...:::....:.|
Zfish   317 MGYPKHTQVQILPEMGETPLFKQFFKNWRDVDQT------EGMGVAYVSNSIAKIEKVPFDASTL 375

  Fly   441 KKSGGRA--FGFMPD-HGQNVIETITQYVAKPGSDEIVVSTVPFDEKLPLLGFASYVLTYNYEAN 502
            ..|...|  .|.:.. :|:..|..|      .|||::.|....:.:   ..|..||::.|:|. :
Zfish   376 HDSPAMAAQHGMIDSGNGEKQIWRI------EGSDKVPVDPSTYGQ---FYGGDSYIILYSYR-H 430

  Fly   503 NGDTGSLTYVWHG-------VKASAAARKRAFEE------GLVGSKDGLLVQTNQGHEPRHFYKI 554
            .|..|.:.|:|.|       :.|||....:..:|      .:.|:.....|:..||.||.|...:
Zfish   431 GGRQGHIIYIWQGADSTQDEIGASAILGAQLDDELGGGPVQMAGAPLTTQVRVVQGKEPAHLMSL 495

  Fly   555 FKGKLLT----------SFTALPVTAQLFRIRGTVESDVHASEVAADSSSLASSDAFVLHSGKSH 609
            |.|:.:.          ..|| |...:||::|........|.|:.|.||:|.|:|||||.:..:.
Zfish   496 FGGQPMVVHKGGTSREGGQTA-PAETRLFQVRSNSAGCTRAVEIDAVSSNLNSNDAFVLVTPAAS 559

  Fly   610 KIYIWNGLGASAFEKQAAVDRFSDYWDDVELEQVEEGAEPDEFWEELNGEGQYDRS--LGD--DG 670
              :||.|.|||..||:.|.......  .|...::.||.|...||:.|.|:..|..|  |.|  :.
Zfish   560 --FIWVGQGASDIEKRGAQQLCGIL--GVSPSELSEGGEDGGFWDALGGKAAYRTSSRLKDKMNA 620

  Fly   671 APLLESRLFHCHLSSGGFLKVEEV-AQYEQEDLDSDDIMLLDAGDEIYLWVGYGVSEEENGKLLD 734
            .|   .|||.|...:|.|: :||| .:..||||.:||:|:||..|::::|:|....:||..:.:.
Zfish   621 HP---PRLFACSNKTGRFI-IEEVPGEMTQEDLATDDVMILDTWDQVFVWIGNEAHDEEKMEAMT 681

  Fly   735 TAKLYFNLEPTARSFDTVSIIRVPQGKEPRVFKRMFPNWDDNYWQNQPSYEDMKQLVI 792
            :|..|...:|..|...| :|:::.||.||..|...|..||.:||...|....|.:|.|
Zfish   682 SAAQYIQTDPANRDPRT-AIVKIKQGFEPPTFTGWFLGWDHDYWSTDPLERAMAELEI 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gel	NP_524865.2	gelsolin_S1_like	63..176	CDD:200446	60/112 (54%)
		gelsolin_S2_like	191..283	CDD:200445	41/91 (45%)
		gelsolin_S3_like	307..404	CDD:200448	43/99 (43%)
		ADF_gelsolin	470..558	CDD:301701	26/100 (26%)
		ADF_gelsolin	569..661	CDD:301701	32/91 (35%)
		gelsolin_S6_like	675..774	CDD:200447	35/99 (35%)
gsna	XP_021324427.1	gelsolin_S1_like	7..119	CDD:200446	60/112 (54%)
		gelsolin_S2_like	135..223	CDD:200445	41/90 (46%)
		gelsolin_S3_like	243..343	CDD:200448	43/99 (43%)
		gelsolin_S4_like	387..496	CDD:200449	28/118 (24%)
		gelsolin_S5_like	518..606	CDD:200444	32/91 (35%)
		gelsolin_S6_like	622..720	CDD:200447	36/102 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574411
Domainoid	1	1.000	94	1.000	Domainoid score	I7404
eggNOG	1	0.900	-	-		E1_KOG0443
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	443	1.000	Inparanoid score	I1618
OMA	1	1.010	-	-		QHG55329
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	1	1.000	-	-		FOG0000527
OrthoInspector	1	1.000	-	-		otm24470
orthoMCL	1	0.900	-	-		OOG6_100298
Panther	1	1.100	-	-	O	PTHR11977
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2540
SonicParanoid	1	1.000	-	-		X232
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.840