Protein Alignment Gel and Scin

DIOPT Version :10

• Sequence 1: NP_524865.2
• Gene: Gel / 46008
• FlyBaseID: FBgn0010225
• Length: 798
• Species: Drosophila melanogaster
• Sequence 2: NP_942043.2
• Gene: Scin / 298975
• RGDID: 735034
• Length: 715
• Species: Rattus norvegicus
• Alignment Length: 759
• Identity: 280/759 - (36%)
• Similarity: 403/759 - (53%)
• Gaps: 80/759 - (10%)

  Fly    55 ARRVMHPSFANAGRTPGLEIWRIENFEPVIYPKTNYGKFYTGDSFIVLNTIENKKDKKLSWDVHF 119
            |:.:.||.||.||:..||::||:|..|.|..|:..||.||.||:::||:|  .|..:..|:.:||
  Rat     2 AQELQHPEFARAGKQAGLQVWRVEKLELVPVPQGAYGDFYVGDAYLVLHT--TKSSRGFSYRLHF 64

  Fly   120 WLGLETSTDEAGAAAILTVQLDDLLNGGPVQHREVQDHESQLFLSYFKNGIRYEQGGVGTGFKHV 184
            |||.|.|.||:.||||.|||:||.|.|.|||.||:|.:||..|:.|||.|::|:.|||.:|..||
  Rat    65 WLGKECSQDESTAAAIFTVQMDDYLGGKPVQSRELQGYESTDFVGYFKGGLKYKAGGVASGLNHV 129

  Fly   185 ETNAQGETRLFQVKGKRNVRVRQVNLSVSSMNTGDCFILDAGSDIYVYVGSQAKRVEKLKAISAA 249
            .||.....||..|||:|.||..:|.||..|.|.|||||:|.|::||.:.||...:.|:|||...|
  Rat   130 LTNDLTAKRLLHVKGRRVVRATEVPLSWQSFNKGDCFIIDLGTEIYQWCGSSCNKYERLKASQVA 194

  Fly   250 NQIRDQDHNGRARVQIVDDFSTDADKQHFFDVLGSGSADQVPDESTADEDSAFERTDAAAVSLYK 314
            ..|||.:..||:::.:|::.|   :......||  |...::||... |:|...:.::.....||.
  Rat   195 TGIRDNERKGRSQLIVVEEGS---EPPELMKVL--GRKPELPDGDN-DDDVIADISNRKMAKLYM 253

  Fly   315 VSDASGKLKVDIIGQK-PLTQAMLDTRECFILDTGSG--IFVWVGKGATQKEKTDAMAKAQEFLR 376
            ||||||.:||.::.:: |.:..||...||||||.|:.  ||||.||.|..:|:..||..|:|||.
  Rat   254 VSDASGSMKVTLVAEENPFSMGMLLPEECFILDHGAAKQIFVWKGKNANPQERKTAMKTAEEFLH 318

  Fly   377 TKKYPAWTQIHRIVEGSESAPFKQYFDTWRDAGMSHSRLIRSALGIG----SDELLNDDEIDSVV 437
            ...|.|.|||..:.||.|:..|||:|..|:|...|.        |.|    ::::....:|....
  Rat   319 KMNYSANTQIQVLPEGGETPIFKQFFKDWKDKDQSD--------GFGKVYITEKVAQIKQIPFDA 375

  Fly   438 TQLKKSGGRAFGF-MPDHGQNVIETITQYVAKPGSDEIVVSTVPFDEKLPLLGFASYVLTYNYEA 501
            ::|..|...|... |.|.|...:|  ...|...|..:|..|:  :.|   ..|...|::.|.|
  Rat   376 SKLHSSPQMAAQHNMVDDGSGGVE--IWRVENSGRVQIDPSS--YGE---FYGGDCYIILYTY-- 431

  Fly   502 NNGDTGSLTYVWHGVKAS------AAARKRAFEEGLVGSKDGLLVQTNQGHEPRHFYKIFKGKLL 560
               ..|.:.|.|.|..|:      :|......:..|.|  ..:.|:.:||.||.|...:||.|.|
  Rat   432 ---PRGQIIYTWQGADATRDELTMSAFLTVQLDRSLGG--QAVQVRVSQGKEPAHLLSLFKDKPL 491

  Fly   561 TSF----------TALPVTAQLFRIRGTVESDVHASEVAADSSSLASSDAFVLHSGKSHKIYIWN 615
            ..:          ...|.| :||::|..:.|.....||..|::||.|:|.|||...:::. :||.
  Rat   492 IIYKNGTSKKGGQAPAPPT-RLFQVRRNLASITRIVEVDVDANSLNSNDTFVLKLPRNNG-FIWI 554

  Fly   616 GLGASAFEKQAAVDRFSDYWDDV---ELEQVEEGAEPDEFWEELNGEGQYDRSLGDDGAPLLES- 676
            |.|||..|::.|     :|..||   :..:::||.||||||..|.|.|.|..|      ||||:
  Rat   555 GKGASQEEEKGA-----EYVADVLKCKTTRIQEGKEPDEFWNSLGGRGDYQTS------PLLETQ 608

  Fly   677 ------RLFHCHLSSGGFLKVEEV-AQYEQEDLDSDDIMLLDAGDEIYLWVGYGVSEEENGKLLD 734
                  ||:.|...:|.|: :||| .::.|:||..||:|||||.::|::|:|...:|.|..:.:.
  Rat   609 AEDHPPRLYGCSNKTGRFI-IEEVPGEFTQDDLAEDDVMLLDAWEQIFIWIGKDANEVEKKESVK 672

  Fly   735 TAKLYFNLEPTARSFDTVSIIRVPQGKEPRVFKRMFPNWDDNYW 778
            :||:|...:|:.|...| .|:.:.||.||..|...|..||.:.|
  Rat   673 SAKMYLETDPSGRDKRT-PIVIIKQGHEPPTFTGWFLGWDSSKW 715

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gel	NP_524865.2	gelsolin_S1_like	63..176	CDD:200446	57/112 (51%)
		gelsolin_S2_like	191..283	CDD:200445	37/91 (41%)
		gelsolin_S3_like	307..404	CDD:200448	46/99 (46%)
		ADF_gelsolin	470..558	CDD:472830	24/93 (26%)
		ADF_gelsolin	569..661	CDD:472830	36/94 (38%)
		gelsolin_S6_like	675..774	CDD:200447	37/106 (35%)
Scin	NP_942043.2	gelsolin_S1_like	10..121	CDD:200446	57/112 (51%)
		gelsolin_S2_like	136..225	CDD:200445	38/93 (41%)
		gelsolin_S3_like	246..346	CDD:200448	46/99 (46%)
		gelsolin_S4_like	390..486	CDD:200449	27/109 (25%)
		gelsolin_S5_like	508..598	CDD:200444	37/96 (39%)
		gelsolin_S6_like	613..711	CDD:200447	36/99 (36%)