DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gel and Gsn

DIOPT Version :9

Sequence 1:	NP_524865.2	Gene:	Gel / 46008	FlyBaseID:	FBgn0010225	Length:	798	Species:	Drosophila melanogaster
Sequence 2:	NP_001004080.1	Gene:	Gsn / 296654	RGDID:	1303089	Length:	780	Species:	Rattus norvegicus

Alignment Length:	806	Identity:	300/806 - (37%)
Similarity:	425/806 - (52%)	Gaps:	78/806 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LSSLLVFLALSSSLCSAGTLNARPAFPVQSGEIQPSGQNSKQAARR-----VMHPSFANAGRTPG 71
            |.|.|:.||    ||:....:|..|   ..|..|.....|:.:..|     |.||.|..||:.||
  Rat     8 LRSALLVLA----LCALSPSHAATA---SRGRAQERAPQSRVSETRPSTMVVEHPEFLKAGKEPG 65

  Fly    72 LEIWRIENFEPVIYPKTNYGKFYTGDSFIVLNTIENKKDKKLSWDVHFWLGLETSTDEAGAAAIL 136
            |:|||:|.|:.|..|...||.|:|||::::|.|:: .::..|.:|:|:|||.|.|.||:|||||.
  Rat    66 LQIWRVEKFDLVPVPPNLYGDFFTGDAYVILKTVQ-LRNGNLQYDLHYWLGNECSQDESGAAAIF 129

  Fly   137 TVQLDDLLNGGPVQHREVQDHESQLFLSYFKNGIRYEQGGVGTGFKHVETNAQGETRLFQVKGKR 201
            ||||||.|||..|||||||..||..|..|||:|::|::|||.:|||||..|.....|||||||:|
  Rat   130 TVQLDDYLNGRAVQHREVQGFESSTFQGYFKSGLKYKKGGVASGFKHVVPNEVVVQRLFQVKGRR 194

  Fly   202 NVRVRQVNLSVSSMNTGDCFILDAGSDIYVYVGSQAKRVEKLKAISAANQIRDQDHNGRARVQIV 266
            .||..:|.:|..|.|.|||||||.|::||.:.||.:.:.|:|||...:..|||.:.:|||:|.:.
  Rat   195 VVRATEVPVSWDSFNNGDCFILDLGNNIYQWCGSGSNKFERLKATQVSKGIRDNERSGRAQVHVS 259

  Fly   267 DDFSTDADKQHFFDVLGSGSADQVPD-----ESTADEDSAFERTDAAAVSLYKVSDASGKLKVDI 326
            ::.|   :.:....|||     ..||     |.||.||:|..|    ...|||||::.|.:.|.:
  Rat   260 EEGS---EPEAMLQVLG-----PKPDLPQGTEDTAKEDAANRR----LAKLYKVSNSGGSMSVSL 312

  Fly   327 IG-QKPLTQAMLDTRECFILDTG--SGIFVWVGKGATQKEKTDAMAKAQEFLRTKKYPAWTQIHR 388
            :. :.|..|:.|.:.:|||||.|  ..||||.||.|...|:..|:..|.:|:...:||..||:..
  Rat   313 VADENPFAQSALRSEDCFILDHGRDGKIFVWKGKQANMDERKAALKTASDFISKMQYPRQTQVSV 377

  Fly   389 IVEGSESAPFKQYFDTWRDAGMSHSRLIRSALGIGSDELLNDDEIDSVVTQLKKSGGRAFGFMPD 453
            :.||.|:..|||:|..|||...:..    ..|...|..:.|.:.:......|..|...|    ..
  Rat   378 LPEGGETPLFKQFFKNWRDPDQTDG----PGLSYLSSHIANVERVPFDAATLHTSTAMA----AQ 434

  Fly   454 HGQNVIETITQYVAK-PGSDEIVVSTVPFDEKLPLLGFASYVLTYNYEANNGDTGSLTYVWHGVK 517
            ||.:...|..:.:.: .||::::|....:.:   ..|..||::.|||. :.|..|.:.|.|.|.:
  Rat   435 HGMDDDGTGQKQIWRIEGSNKVLVDPATYGQ---FYGGDSYIILYNYR-HGGRQGQIIYNWQGAQ 495

  Fly   518 ------ASAAARKRAFEEGLVGSKDGLLVQTN--QGHEPRHFYKIFKGKLLTSF---------TA 565
                  |::|......:|.|.|:.    ||:.  ||.||.|...:|.||.:..:         ..
  Rat   496 STQDEVAASAILTAQLDEELGGTP----VQSRVVQGKEPAHLMSLFGGKPMIIYKGGTSRDGGQT 556

  Fly   566 LPVTAQLFRIRGTVESDVHASEVAADSSSLASSDAFVLHSGKSHKIYIWNGLGASAFEKQAAVDR 630
            .|.:.:||::|.:......|.||...:.:|.|:|||||.:..:  .|:|.|.|||..||..|::.
  Rat   557 TPASTRLFQVRASSSGATRAVEVMPKAGALNSNDAFVLKTPSA--AYLWVGTGASDAEKTGALEL 619

  Fly   631 FSDYWDDVELEQVEEGAEPDEFWEELNGEGQYDRS--LGDDGAPLLESRLFHCHLSSGGFLKVEE 693
            ....  ..:..|||||:|||.|||.|.|:..|..|  |.|........|||.|....|.|: :||
  Rat   620 LKVL--RAQHVQVEEGSEPDGFWEALGGKTAYRTSPRLKDKKMDAHPPRLFACSNRIGRFV-IEE 681

  Fly   694 V-AQYEQEDLDSDDIMLLDAGDEIYLWVGYGVSEEENGKLLDTAKLYFNLEPTARSFDT-VSIIR 756
            | .:..||||.:||:||||..|::::|||....|||..:.|.:||.|...:|..|...| ::::|
  Rat   682 VPGELMQEDLATDDVMLLDTWDQVFVWVGKDSQEEEKTEALTSAKRYIETDPANRDRRTPITVVR 746

  Fly   757 VPQGKEPRVFKRMFPNWDDNYWQNQP 782
              ||.||..|...|..|||:||...|
  Rat   747 --QGFEPPSFVGWFLGWDDDYWSVDP 770

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gel	NP_524865.2	gelsolin_S1_like	63..176	CDD:200446	60/112 (54%)
		gelsolin_S2_like	191..283	CDD:200445	39/91 (43%)
		gelsolin_S3_like	307..404	CDD:200448	38/99 (38%)
		ADF_gelsolin	470..558	CDD:301701	27/95 (28%)
		ADF_gelsolin	569..661	CDD:301701	35/91 (38%)
		gelsolin_S6_like	675..774	CDD:200447	40/100 (40%)
Gsn	NP_001004080.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..48		5/22 (23%)
		Actin-severing. /evidence=ECO:0000255	51..174		66/123 (54%)
		gelsolin_S1_like	57..169	CDD:200446	60/112 (54%)
		Actin-actin interfilament contact point. /evidence=ECO:0000250	121..124		2/2 (100%)
		Polyphosphoinositide binding. /evidence=ECO:0000250	160..167		3/6 (50%)
		gelsolin_S2_like	184..273	CDD:200445	39/91 (43%)
		Polyphosphoinositide binding. /evidence=ECO:0000250	186..194		7/7 (100%)
		Gelsolin-like 2	196..236		19/39 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	244..286		14/49 (29%)
		gelsolin_S3_like	296..393	CDD:200448	38/96 (40%)
		Gelsolin-like 3	312..354		17/41 (41%)
		Actin-binding, Ca-sensitive. /evidence=ECO:0000255	432..780		119/358 (33%)
		gelsolin_S4_like	437..537	CDD:200449	27/107 (25%)
		gelsolin_S5_like	559..647	CDD:200444	35/91 (38%)
		gelsolin_S6_like	664..762	CDD:200447	40/100 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335149
Domainoid	1	1.000	91	1.000	Domainoid score	I7502
eggNOG	1	0.900	-	-		E1_KOG0443
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	456	1.000	Inparanoid score	I1529
OMA	1	1.010	-	-		QHG55329
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	1	1.000	-	-		FOG0000527
OrthoInspector	1	1.000	-	-		otm45767
orthoMCL	1	0.900	-	-		OOG6_100298
Panther	1	1.100	-	-	O	PTHR11977
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X232
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.810