DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Gel and GSN

DIOPT Version :10

Sequence 1:NP_524865.2 Gene:Gel / 46008 FlyBaseID:FBgn0010225 Length:798 Species:Drosophila melanogaster
Sequence 2:NP_000168.1 Gene:GSN / 2934 HGNCID:4620 Length:782 Species:Homo sapiens


Alignment Length:802 Identity:303/802 - (37%)
Similarity:423/802 - (52%) Gaps:65/802 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 ALSSSLCSAGTLNARPAF----PVQSGEIQPSGQNSKQAARRVMHPSFANAGRTPGLEIWRIENF 80
            |||.:|| |.:|..|.|.    ..|:|..|.....::..:..|.||.|..||:.|||:|||:|.|
Human    13 ALSLALC-ALSLPVRAATASRGASQAGAPQGRVPEARPNSMVVEHPEFLKAGKEPGLQIWRVEKF 76

  Fly    81 EPVIYPKTNYGKFYTGDSFIVLNTIENKKDKKLSWDVHFWLGLETSTDEAGAAAILTVQLDDLLN 145
            :.|..|...||.|:|||::::|.|:: .::..|.:|:|:|||.|.|.||:|||||.||||||.||
Human    77 DLVPVPTNLYGDFFTGDAYVILKTVQ-LRNGNLQYDLHYWLGNECSQDESGAAAIFTVQLDDYLN 140

  Fly   146 GGPVQHREVQDHESQLFLSYFKNGIRYEQGGVGTGFKHVETNAQGETRLFQVKGKRNVRVRQVNL 210
            |..|||||||..||..||.|||:|::|::|||.:|||||..|.....|||||||:|.||..:|.:
Human   141 GRAVQHREVQGFESATFLGYFKSGLKYKKGGVASGFKHVVPNEVVVQRLFQVKGRRVVRATEVPV 205

  Fly   211 SVSSMNTGDCFILDAGSDIYVYVGSQAKRVEKLKAISAANQIRDQDHNGRARVQIVDDFSTDADK 275
            |..|.|.|||||||.|::|:.:.||.:.|.|:|||...:..|||.:.:|||||.:.::   ..:.
Human   206 SWESFNNGDCFILDLGNNIHQWCGSNSNRYERLKATQVSKGIRDNERSGRARVHVSEE---GTEP 267

  Fly   276 QHFFDVLGSGSADQVPDESTADEDSAFERTDAAAVSLYKVSDASGKLKVDIIG-QKPLTQAMLDT 339
            :....|||...|.....|.||.||:|    :.....|||||:.:|.:.|.::. :.|..|..|.:
Human   268 EAMLQVLGPKPALPAGTEDTAKEDAA----NRKLAKLYKVSNGAGTMSVSLVADENPFAQGALKS 328

  Fly   340 RECFILDTGSG--IFVWVGKGATQKEKTDAMAKAQEFLRTKKYPAWTQIHRIVEGSESAPFKQYF 402
            .:|||||.|..  ||||.||.|..:|:..|:..|.:|:....||..||:..:.||.|:..|||:|
Human   329 EDCFILDHGKDGKIFVWKGKQANTEERKAALKTASDFITKMDYPKQTQVSVLPEGGETPLFKQFF 393

  Fly   403 DTWRDAGMSHSRLIRSALGIG--SDELLNDDEIDSVVTQLKKSGGRAFGFMPDHGQNVIETITQY 465
            ..|||...:      ..||:.  |..:.|.:.:......|..|...|    ..||.:...|..:.
Human   394 KNWRDPDQT------DGLGLSYLSSHIANVERVPFDAATLHTSTAMA----AQHGMDDDGTGQKQ 448

  Fly   466 VAK-PGSDEIVVSTVPFDEKLPLLGFASYVLTYNYEANNGDTGSLTYVWHGVK------ASAAAR 523
            :.: .||:::.|....:.:   ..|..||::.|||. :.|..|.:.|.|.|.:      |::|..
Human   449 IWRIEGSNKVPVDPATYGQ---FYGGDSYIILYNYR-HGGRQGQIIYNWQGAQSTQDEVAASAIL 509

  Fly   524 KRAFEEGLVGSKDGLLVQTN--QGHEPRHFYKIFKGKLLTSF----------TALPVTAQLFRIR 576
            ....:|.|.|:.    ||:.  ||.||.|...:|.||.:..:          || |.:.:||::|
Human   510 TAQLDEELGGTP----VQSRVVQGKEPAHLMSLFGGKPMIIYKGGTSREGGQTA-PASTRLFQVR 569

  Fly   577 GTVESDVHASEVAADSSSLASSDAFVLHSGKSHKIYIWNGLGASAFEKQAAVDRFSDYWDDVELE 641
            ........|.||...:.:|.|:|||||.:..:  .|:|.|.|||..||..|.:.....  ..:..
Human   570 ANSAGATRAVEVLPKAGALNSNDAFVLKTPSA--AYLWVGTGASEAEKTGAQELLRVL--RAQPV 630

  Fly   642 QVEEGAEPDEFWEELNGEGQYDRS--LGDDGAPLLESRLFHCHLSSGGFLKVEEV-AQYEQEDLD 703
            ||.||:|||.|||.|.|:..|..|  |.|........|||.|....|.|: :||| .:..||||.
Human   631 QVAEGSEPDGFWEALGGKAAYRTSPRLKDKKMDAHPPRLFACSNKIGRFV-IEEVPGELMQEDLA 694

  Fly   704 SDDIMLLDAGDEIYLWVGYGVSEEENGKLLDTAKLYFNLEPTARSFDTVSIIRVPQGKEPRVFKR 768
            :||:||||..|::::|||....|||..:.|.:||.|...:|..|...| .|..|.||.||..|..
Human   695 TDDVMLLDTWDQVFVWVGKDSQEEEKTEALTSAKRYIETDPANRDRRT-PITVVKQGFEPPSFVG 758

  Fly   769 MFPNWDDNYWQNQPSYEDMKQL 790
            .|..|||:||...|....|.:|
Human   759 WFLGWDDDYWSVDPLDRAMAEL 780

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GelNP_524865.2 gelsolin_S1_like 63..176 CDD:200446 61/112 (54%)
gelsolin_S2_like 191..283 CDD:200445 39/91 (43%)
gelsolin_S3_like 307..404 CDD:200448 38/99 (38%)
ADF_gelsolin 470..558 CDD:472830 27/95 (28%)
ADF_gelsolin 569..661 CDD:472830 34/91 (37%)
gelsolin_S6_like 675..774 CDD:200447 41/99 (41%)
GSNNP_000168.1 Actin-severing. /evidence=ECO:0000255 53..176 67/123 (54%)
gelsolin_S1_like 59..171 CDD:200446 61/112 (54%)
Actin-actin interfilament contact point 123..126 2/2 (100%)
gelsolin_S2_like 186..275 CDD:200445 39/91 (43%)
Gelsolin-like 2. /evidence=ECO:0000255 198..270 30/74 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 247..285 12/40 (30%)
gelsolin_S3_like 295..395 CDD:200448 38/99 (38%)
Gelsolin-like 3. /evidence=ECO:0000255 317..389 27/71 (38%)
Actin-binding, Ca-sensitive. /evidence=ECO:0000255 434..782 123/366 (34%)
gelsolin_S4_like 439..539 CDD:200449 27/107 (25%)
gelsolin_S5_like 561..649 CDD:200444 34/91 (37%)
gelsolin_S6_like 666..764 CDD:200447 41/99 (41%)

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