Protein Alignment Gel and Avil

DIOPT Version :10

• Sequence 1: NP_524865.2
• Gene: Gel / 46008
• FlyBaseID: FBgn0010225
• Length: 798
• Species: Drosophila melanogaster
• Sequence 2: XP_006513161.1
• Gene: Avil / 11567
• MGIID: 1333798
• Length: 878
• Species: Mus musculus
• Alignment Length: 843
• Identity: 289/843 - (34%)
• Similarity: 418/843 - (49%)
• Gaps: 127/843 - (15%)

  Fly    25 LCSAGTLNARPAFPVQSGEIQPSGQNSKQAARRVMHPSFANAGRTPGLEIWRIENFEPVIYPKTN 89
            :|..|.:::.....:..|:     .:|::.|...:..:|......|.:..||||..|..:.|.:.
Mouse     3 VCFKGNVSSLWPRALDQGD-----SSSRKTATMSLSSAFRAVSNDPRIITWRIEKMELALVPLSA 62

  Fly    90 YGKFYTGDSFIVLNTIENKKDKKLSWDVHFWLGLETSTDEAGAAAILTVQLDDLLNGGPVQHREV 154
            :|.||.||.:|||:|  .:....||.::|||:|.::|.||...|||.|.||||.|.|.|||||||
Mouse    63 HGNFYEGDCYIVLST--RRVGSLLSQNIHFWIGKDSSQDEQSCAAIYTTQLDDYLGGSPVQHREV 125

  Fly   155 QDHESQLFLSYFKNGIRYEQGGVGTGFKHVETNAQGETRLFQVKGKRNVRV-------------- 205
            |.|||..|..|||.||.|::|||.:|.||||||.....||..||||||::.
Mouse   126 QYHESDTFRGYFKQGIIYKKGGVASGMKHVETNTYDVKRLLHVKGKRNIQATEVSLTRECPGCPV 190

  Fly   206 ----------------RQVNLSVSSMNTGDCFILDAGSDIYVYVGSQAKRVEKLKAISAANQIRD 254
                            .||.:|..|.|.||.|:||.|..|..:.|.::...|:|||:..|..|||
Mouse   191 LPPWHLRLPRTALTAHTQVEMSWDSFNRGDVFLLDLGMVIIQWNGPESNSGERLKAMLLAKDIRD 255

  Fly   255 QDHNGRARVQIVDDFSTDADKQH--------FFDVLGSGSADQVPDESTADEDSAFERTDAAAVS 311
            ::..|||.:.::     :.||:.        ..|.||..|..:     .|..|...::...:::.
Mouse   256 RERGGRAEIGVI-----EGDKEAASPGLMTVLQDTLGRRSMIK-----PAVSDEIMDQQQKSSIM 310

  Fly   312 LYKVSDASGKLKVDIIGQKPLTQAMLDTRECFILD-TGSGIFVWVGKGATQKEKTDAMAKAQEFL 375
            ||.|||.:|:|.|..:..:||.|.:|:..:|:||| :|:.|:||.|||||:.||..||:||.:|:
Mouse   311 LYHVSDTAGQLSVTEVATRPLVQDLLNHDDCYILDQSGTKIYVWKGKGATKVEKQAAMSKALDFI 375

  Fly   376 RTKKYPAWTQIHRIVEGSESAPFKQYFDTW--RDAGMSHSRLIRSALGIGSDELLNDDEIDSVVT 438
            :.|.||:.|.:..:.:|:|||.|||.|..|  :|          ...|:|
Mouse   376 KMKGYPSSTNVETVNDGAESAMFKQLFQKWSVKD----------QTTGLG--------------- 415

  Fly   439 QLKKSGGRAFGFMPDHGQNVIETITQYVAK-----PGSDEIVVSTVPFDEKLPL--------LGF 490
            ::..:|..|..|......:::.|..:..|:     .|..::.|..:...|.:|:        .|.
Mouse   416 KIFSTGKIAKIFQDKFDVSLLHTKPEVAAQERMVDDGKGQVEVWRIENLELVPVEYQWHGFFYGG 480

  Fly   491 ASYVLTYNYEANNGDTGSLTYVWHGVKAS----AAARKRAFEEGLVGSK-DGLLVQ--TNQGHEP 548
            ..|::.|.|:. ||....:.|:|.|..||    ||:..||.|   |..: ||..||  .:.|.||
Mouse   481 DCYLVLYTYDV-NGKPHYILYIWQGRHASRDELAASAYRAVE---VDQQFDGAPVQVRVSMGKEP 541

  Fly   549 RHFYKIFKGKLL-----TSFTA-----LPVTAQLFRIRGTVESDVHASEVAADSSSLASSDAFVL 603
            |||..||||||:     ||...     .||  :||:|.|..:|:..|.||:|.:|||.|:|.|:|
Mouse   542 RHFMAIFKGKLVIYEGGTSRKGNEEPDPPV--RLFQIHGNDKSNTKAVEVSASASSLNSNDVFLL 604

  Fly   604 HSGKSHKIYIWNGLGASAFEKQAAVDRFSDYWDDVELEQVEEGAEPDEFWEELNGEGQY--DRSL 666
            .:...|  |:|.|.|:|. :::|......|...|...:.|.||.||.|||:.|.|:..|  |:.|
Mouse   605 RTQAEH--YLWYGKGSSG-DERAMAKELVDLLCDGNADTVAEGQEPPEFWDLLGGKTAYANDKRL 666

  Fly   667 GDDGAPLLESRLFHCHLSSGGFLKVEEVAQYEQEDLDSDDIMLLDAGDEIYLWVGYGVSEEENGK 731
            ..:... ::.|||.|...:|.|| |.||..:.||||...|:||||..|:::||:|...:..|...
Mouse   667 QQETLD-VQVRLFECSNKTGRFL-VTEVTDFTQEDLSPGDVMLLDTWDQVFLWIGAEANATEKKG 729

  Fly   732 LLDTAKLYFNLEPTARSFDTVSIIRVPQGKEPRVFKRMFPNWDDNYWQNQPSYEDMKQLVIDA 794
            .|.||:.|....|:.|..|| .|:.:.||.||..|...|..||.:.|....|||.:|..:.||
Mouse   730 ALSTAQEYLVTHPSGRDPDT-PILIIKQGFEPPTFTGWFLAWDPHIWSEGKSYEQLKNELGDA 791

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gel	NP_524865.2	gelsolin_S1_like	63..176	CDD:200446	54/112 (48%)
		gelsolin_S2_like	191..283	CDD:200445	35/129 (27%)
		gelsolin_S3_like	307..404	CDD:200448	44/97 (45%)
		ADF_gelsolin	470..558	CDD:472830	34/102 (33%)
		ADF_gelsolin	569..661	CDD:472830	35/91 (38%)
		gelsolin_S6_like	675..774	CDD:200447	39/98 (40%)
Avil	XP_006513161.1	gelsolin_S1_like	36..147	CDD:200446	54/112 (48%)
		gelsolin_S2_like	162..282	CDD:200445	34/124 (27%)
		gelsolin_S3_like	306..404	CDD:200448	44/97 (45%)
		gelsolin_S4_like	448..548	CDD:200449	31/103 (30%)
		gelsolin_S5_like	569..658	CDD:200444	37/93 (40%)
		gelsolin_S6_like	676..771	CDD:200447	39/96 (41%)
		VHP	843..878	CDD:460493