DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gel and scin

DIOPT Version :9

Sequence 1:	NP_524865.2	Gene:	Gel / 46008	FlyBaseID:	FBgn0010225	Length:	798	Species:	Drosophila melanogaster
Sequence 2:	XP_002939059.1	Gene:	scin / 100495760	XenbaseID:	XB-GENE-957027	Length:	714	Species:	Xenopus tropicalis

Alignment Length:	764	Identity:	295/764 - (38%)
Similarity:	421/764 - (55%)	Gaps:	93/764 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 VMHPSFANAGRTPGLEIWRIENFEPVIYPKTNYGKFYTGDSFIVLNTIENKKDKKLSWDVHFWLG 122
            |.|..|.|||::.||:||||||.:.|..|||.||.||.||:::|||||.....|  .:|:|:|||
Frog     3 VYHKQFENAGQSTGLQIWRIENMDLVPVPKTLYGNFYVGDAYLVLNTIAKNNSK--YYDLHYWLG 65

  Fly   123 LETSTDEAGAAAILTVQLDDLLNGGPVQHREVQDHESQLFLSYFKNGIRYEQGGVGTGFKHVETN 187
            .|.|.||:.||||.|||||:.|.|.|||:||:|.|||..|:.|||.||:|:.|||.:||:||.||
Frog    66 KECSQDESTAAAIYTVQLDEFLGGKPVQYREIQGHESSAFVGYFKGGIKYKAGGVASGFQHVVTN 130

  Fly   188 AQGETRLFQVKGKRNVRVRQVNLSVSSMNTGDCFILDAGSDIYVYVGSQAKRVEKLKAISAANQI 252
            ..|..||..:||:|.||..:|.||.|:.|:|||||:|.|:.||.:.||:..:.|:|||...|:.|
Frog   131 ELGAQRLLHIKGRRVVRATEVPLSWSNFNSGDCFIVDLGAVIYQWCGSECNKYERLKAAQVAHGI 195

  Fly   253 RDQDHNGRARVQIVDDFSTDADKQHFFDVLGSGSADQVPDESTADEDSAFERTDAAAVSLYKVSD 317
            ||.:.||||::.:|::.|   :......||  |:..|:|  :..|.|...:.|:...|.||.|||
Frog   196 RDNEKNGRAQIIVVEEGS---EPNELTKVL--GAKPQLP--AGDDADDVADDTNRKNVKLYMVSD 253

  Fly   318 ASGKLKVDIIG-QKPLTQAMLDTRECFILDTGSG---IFVWVGKGATQKEKTDAMAKAQEFLRTK 378
            |||.:||.::. |.|.::|||.:.|||||| .||   ||||.||.|..:|:..||..|::|::..
Frog   254 ASGSMKVSVVAEQSPFSKAMLLSEECFILD-HSGDKKIFVWKGKNANTEERKAAMKTAEQFIQQM 317

  Fly   379 KYPAWTQIHRIVEGSESAPFKQYFDTWRDAGMSHSRLIRSALGIG----SDELLNDDEIDSVVTQ 439
            .|||.|||..:.|..|:..|||:|..|::...|.        |.|    ::.:.|..:||...::
Frog   318 NYPATTQIQVLPEEGETPIFKQFFKDWKERHQSE--------GFGQVYVTERIANIKQIDFDASK 374

  Fly   440 LKKSGGRAFGFMPDHGQNVIETITQYVAKPGSDEIVVSTVPFDEKLPL--------LGFASYVLT 496
            |.:|...|    ..|  |:::        .||.::.:..|....::|:        .|...|::.
Frog   375 LHESPEMA----AQH--NMVD--------DGSGKVEIFRVESCGRVPIEPNTFGQFYGGDCYIIL 425

  Fly   497 YNYEANNGDTGSLTYVWHGVKA-----SAAARKRAFEEGLVGSKDGLLVQTNQGHEPRHFYKIFK 556
            |.|.     .|.:.|.|.|.||     :|:|......:..:|.: .:.|:..||.||.|...:||
Frog   426 YTYA-----KGLIIYTWQGAKATRDELTASAFLTVQLDRSLGDQ-AVQVRVTQGKEPPHLLSLFK 484

  Fly   557 GKLLTSF---------TALPVTAQLFRIRGTVESDVHASEVAADSSSLASSDAFVLHSGKSHKIY 612
            .|.|..:         ...|...:||:||..:.:.....||..|:|.|.|:|.|||.. |::..|
Frog   485 DKPLIIYKDGTSRKGGQTPPSAVRLFQIRKNLSTITRIIEVDTDASLLNSNDVFVLKL-KNNSGY 548

  Fly   613 IWNGLGASAFEKQAAVDRFSDYWDDV---ELEQVEEGAEPDEFWEELNGEGQYDRSLGDDGAPLL 674
            .|.|.|||..|::||     :|..:|   ::.::.||.||||||..|||:.:|..|      .||
Frog   549 KWIGKGASGEEEKAA-----EYIANVLRCKVSKIAEGQEPDEFWSALNGKKKYQTS------ALL 602

  Fly   675 ES-------RLFHCHLSSGGFLKVEEV-AQYEQEDLDSDDIMLLDAGDEIYLWVGYGVSEEENGK 731
            ||       |||.|...:|.|| :||| .::.|:||..||:||||..::::||:|...:|:|..:
Frog   603 ESKSIVNPPRLFGCSNKTGRFL-IEEVPGEFTQDDLAEDDVMLLDTHEQVFLWIGKDANEQEKKE 666

  Fly   732 LLDTAKLYFNLEPTARSFDTVSIIRVPQGKEPRVFKRMFPNWDDNYWQN 780
            .|.:||.|...:|:.|. ..:.|:.|.||.||..|...|..||.|.||:
Frog   667 SLKSAKQYIETDPSGRD-KGIPIVSVKQGHEPPNFTGWFMAWDSNKWQS 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gel	NP_524865.2	gelsolin_S1_like	63..176	CDD:200446	64/112 (57%)
		gelsolin_S2_like	191..283	CDD:200445	38/91 (42%)
		gelsolin_S3_like	307..404	CDD:200448	48/100 (48%)
		ADF_gelsolin	470..558	CDD:301701	25/100 (25%)
		ADF_gelsolin	569..661	CDD:301701	37/94 (39%)
		gelsolin_S6_like	675..774	CDD:200447	40/106 (38%)
scin	XP_002939059.1	gelsolin_S1_like	8..119	CDD:200446	64/112 (57%)
		gelsolin_S2_like	134..223	CDD:200445	39/93 (42%)
		gelsolin_S3_like	243..343	CDD:200448	48/100 (48%)
		gelsolin_S4_like	387..483	CDD:200449	23/109 (21%)
		gelsolin_S5_like	505..595	CDD:200444	37/95 (39%)
		gelsolin_S6_like	610..708	CDD:200447	38/99 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	94	1.000	Domainoid score	I7326
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	455	1.000	Inparanoid score	I1540
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	1	1.000	-	-		FOG0000527
OrthoInspector	1	1.000	-	-		otm48862
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2540
SonicParanoid	1	1.000	-	-		X232
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.090