DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gel and vil1

DIOPT Version :9

Sequence 1:	NP_524865.2	Gene:	Gel / 46008	FlyBaseID:	FBgn0010225	Length:	798	Species:	Drosophila melanogaster
Sequence 2:	NP_001096367.1	Gene:	vil1 / 100124960	XenbaseID:	XB-GENE-965127	Length:	824	Species:	Xenopus tropicalis

Alignment Length:	755	Identity:	263/755 - (34%)
Similarity:	387/755 - (51%)	Gaps:	62/755 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 TPGLEIWRIENFEPVIYPKTNYGKFYTGDSFIVLNTIENKKDKKLSWDVHFWLGLETSTDEAGAA 133
            ||||:|||:|:...|..|:.:||.|:.||.:::|.|  :|.....::|:|||:|.::|.||.|||
Frog    16 TPGLQIWRVESMNLVPVPENSYGNFFDGDCYVLLMT--HKTGNNFTYDIHFWVGNDSSMDEQGAA 78

  Fly   134 AILTVQLDDLLNGGPVQHREVQDHESQLFLSYFKNGIRYEQGGVGTGFKHVETNAQGETRLFQVK 198
            ||.|:|:||.|.|..:||||||.|||..|..|||:||.|:.|||.:|..|||||.....||...|
Frog    79 AIYTIQMDDHLGGAAIQHREVQGHESDTFKGYFKHGIIYKSGGVASGMNHVETNTYNVKRLLHCK 143

  Fly   199 GKRNVRVRQVNLSVSSMNTGDCFILDAGSDIYVYVGSQAKRVEKLKAISAANQIRDQDHNGRARV 263
            ||:||...:|.:..||.|.||.|:||.|..|..:.|.::.:.|:|:.::.|..|||::..||:.|
Frog   144 GKKNVLAGEVPVEWSSFNVGDVFLLDLGKLIIQWNGPESNKQERLRGMTLAKDIRDRERGGRSYV 208

  Fly   264 QIVDDFSTDADKQ---HFFDVLGSGS--ADQVPDESTADEDSAFERTDAAAVSLYKVSDASGKLK 323
            .:|:..:.:...|   ....|||...  ...:|||       ..::....::.|::|||.||.|.
Frog   209 GVVEGDNEEQSPQLMAIMTYVLGERKEIRGAIPDE-------VVDQVAKTSIKLFQVSDNSGNLM 266

  Fly   324 VDIIGQKPLTQAMLDTRECFILD-TGSGIFVWVGKGATQKEKTDAMAKAQEFLRTKKYPAWTQIH 387
            |..:..:||||.:|...:|:||| .||.||||.||.|:::||..||.:|..|:|.|.|||.|.:.
Frog   267 VQEVATQPLTQDLLKHDDCYILDQAGSKIFVWKGKNASKEEKQQAMTRALNFIRAKNYPASTNVE 331

  Fly   388 RIVEGSESAPFKQYFDTWRDAGMSHSRLIRSALGIGSDELLNDDEIDSVVTQLKKSGGRAFGFMP 452
            ...:|||||.|||.|..|.....:        .|:|.         .|.|.::.|.....|....
Frog   332 VENDGSESAVFKQLFQKWTTKDQT--------TGLGK---------TSTVGKVAKVEQVKFDVNS 379

  Fly   453 DHGQNVIETITQYVAKPGSDEIVVSTVPFDEKL--------PLLGFASYVLTYNYEANNGDTGSL 509
            .|.:..: ...|.:...|:.|..|..:...|::        ...|...|::.|.|..|| ....:
Frog   380 MHAKPEV-AAQQKMVDDGTGETEVWRIENLERVLVDKQYLGHFYGGDCYLILYKYLVNN-KYHYI 442

  Fly   510 TYVWHGVKASA-AARKRAFEEGLVGSKDG---LLVQTNQGHEPRHFYKIFKGKLL--------TS 562
            .|:|.|..||. .....|::..::..:.|   :.|:...|.||.|...|||||::        ..
Frog   443 VYMWQGRHASQDEITASAYQSVILDQEYGGQPVQVRVPMGKEPAHLMAIFKGKMVVYEGGTSRAD 507

  Fly   563 FTALPVTAQLFRIRGTVESDVHASEVAADSSSLASSDAFVLHSGKSHKIYIWNGLGASAFEKQAA 627
            .:.:|...:||::.|..|....|.||...:|||.|:|.|||.:  ....|:|.|.|.|. :::|.
Frog   508 SSEIPADIRLFQVHGANEYSTKAFEVPVRASSLNSNDVFVLKT--KGTCYLWCGKGCSG-DERAM 569

  Fly   628 VDRFSDYWDDVELEQVEEGAEPDEFWEELNGEGQY--DRSLGDDGAPLLESRLFHCHLSSGGFLK 690
            ....:|.....|...:.||.||.:||..|.|:.||  ::.|.::... :..|||.|...:|.|:
Frog   570 AKNVADIISKGEKVVIAEGQEPSDFWLALGGKSQYANNKRLQEETLD-ITPRLFECSNKTGKFV- 632

  Fly   691 VEEVAQYEQEDLDSDDIMLLDAGDEIYLWVGYGVSEEENGKLLDTAKLYFNLEPTARSFDTVSII 755
            ..|::.:.|:|||.||:.||||.|:|::|:|...:|.|..:...||:.|....|..|..:| .||
Frog   633 ATEISDFNQDDLDEDDVFLLDAWDQIFMWIGKNSNETEKKEAAMTAQEYLKTHPGGRDINT-PII 696

  Fly   756 RVPQGKEPRVFKRMFPNWDDNYWQNQPSYEDMKQLVIDAN 795
            .|.|..||..|...|..||...|:|..||.|:|..:.||:
Frog   697 VVKQDYEPPTFTGWFLAWDPFKWENMKSYNDLKSELGDAS 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gel	NP_524865.2	gelsolin_S1_like	63..176	CDD:200446	53/106 (50%)
		gelsolin_S2_like	191..283	CDD:200445	31/94 (33%)
		gelsolin_S3_like	307..404	CDD:200448	47/97 (48%)
		ADF_gelsolin	470..558	CDD:301701	25/99 (25%)
		ADF_gelsolin	569..661	CDD:301701	31/91 (34%)
		gelsolin_S6_like	675..774	CDD:200447	37/98 (38%)
vil1	NP_001096367.1	gelsolin_S1_like	17..121	CDD:200446	52/105 (50%)
		gelsolin_S2_like	136..227	CDD:200445	30/90 (33%)
		gelsolin_S3_like	253..348	CDD:200448	47/94 (50%)
		gelsolin_S4_like	392..492	CDD:200449	22/100 (22%)
		gelsolin_S5_like	515..603	CDD:200444	31/90 (34%)
		gelsolin_S6_like	619..715	CDD:200447	37/97 (38%)
		VHP	790..824	CDD:280388
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	94	1.000	Domainoid score	I7326
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	455	1.000	Inparanoid score	I1540
OMA	1	1.010	-	-		QHG55329
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	1	1.000	-	-		FOG0000527
OrthoInspector	1	1.000	-	-		otm48862
Panther	1	1.100	-	-	O	PTHR11977
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X232
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.080