DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment east and east

DIOPT Version :10

Sequence 1:NP_001245484.1 Gene:east / 46006 FlyBaseID:FBgn0261954 Length:2342 Species:Drosophila melanogaster
Sequence 2:XP_061519465.1 Gene:east / 5667736 VectorBaseID:AGAMI1_012467 Length:2534 Species:Anopheles gambiae


Alignment Length:2778 Identity:714/2778 - (25%)
Similarity:1025/2778 - (36%) Gaps:893/2778 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   174 KEAKEVKSEEP-PAAASESRAASG-VTPGQVKEQHVADGNEMESLPITDKKDHK----------- 225
            |:|:.|.::.| |:..|.:..:|| ::...:........:..:|.|.|.....|           
Mosquito     6 KKARSVTADSPTPSLGSANSGSSGNISALAISSSSTGAASGNDSAPTTPTSTRKAAAVASTVAAA 70

  Fly   226 --DTKDKGDERETDQEEEKEKSADTEIIADTEKTSEKQKYTEKDKAADKDGGKEKDIDANKDIDK 288
              .:...|....|:....:         ....:...||:..::...||     |..:|....|:.
Mosquito    71 GGGSSSSGGSGSTNTSSTR---------GSLSRLKSKQQLLQQGGGAD-----EGAVDELAGIES 121

  Fly   289 EKEKVKEVLPPVVPIAPVTPTCNRVTRKSHA----------------QEQAINTRVT-------R 330
                       :...|..|.|.:|.||...|                ...|..|..|       :
Mosquito   122 -----------IAVAATTTTTPSRTTRGGSALLREDSAGRESPAAKDDTTATTTTTTAGPGGASK 175

  Fly   331 NRRQSSTVGAN---STASLVAASSSVTEQPPPSRGRRKKPVVVAPPLEPAVKRK----------- 381
            :..:|..:||.   :||:..|.:::.|...|.:..:.||..||.......:|||           
Mosquito   176 DLTKSPAIGARRAAATATTTATTATTTSSKPAATAQSKKKRVVTLKRAGLLKRKGKKIIGKPMLG 240

  Fly   382 -----RSQDVEADSDANNSTKYSKVEVVKSEEAEAPEEDSSA---------------------VP 420
                 |.|.|.|..........:.|:.|.::..|..||.::|                     |.
Mosquito   241 RKVEARRQLVTAAKSTGTRGAAATVKDVLADSKEKEEEATAATTPSLRNGKPRNSDSPVAKRKVV 305

  Fly   421 IKQESVDGNEVSSISPTVTPTPTPAPTPAPVPGSRRG----------------------RGRPQN 463
            :||:...|:...|            |..|.:...|.|                      ..|.:.
Mosquito   306 LKQQEAAGSSNKS------------PDSASMERRRSGSVLTEDGAEQTVAEMKRELLDYESRSKM 358

  Fly   464 RNSSSPATTTRATRLSKAGSPVILTPVAQEPAPPKRRRVGSSTRKTVSASSLAPSSQ-----GGA 523
            .:..:.|...|......|.|||:      |....:|   ....||:.:...|||.::     ||:
Mosquito   359 LDKMAEAFNERKAAGGGAASPVV------EKGTLRR---SMRQRKSTAREELAPPARGKSVGGGS 414

  Fly   524 GDEDSKDSMASSMDDLLMAAADIKQEKLTPDFDDSLMPEGLPSTSGASSANGHSCTEPLTVDTEI 588
            |..:.|...|.|:                    :||..||....|..::.   |...|||:||.:
Mosquito   415 GTVEIKLEPAESL--------------------ESLTVEGSEQDSSTAAV---SVDAPLTIDTTV 456

  Fly   589 NVKPADSKVKPKESP--------------VVAVEESPSQSETQSAKV-------SAHAGKAPSLS 632
            .........:|..|.              |:|.....:..|.:...|       :..:||.||||
Mosquito   457 ATVDGGVACEPLHSDGTTVSSLGGVSSGGVIAGASGTASEEVELGSVVGIGGGSAGGSGKDPSLS 521

  Fly   633 P-DMISEGVSAVSVRKFYKKPEFLENNLGIEKDPELGEIVQ-------------------TVSNN 677
            | :::|||||..||::.|.:|.||||||||||||:||||||                   ||.:|
Mosquito   522 PGELVSEGVSEQSVKECYSEPAFLENNLGIEKDPKLGEIVQGRFRCDKVSDDAEDNAKSETVGDN 586

  Fly   678 -------------------DTETDVEMAVDGEVNQPSTPKSQDKKKEEQEKNQKSG------LKA 717
                               |.|.:.|..|..|..: .....|..|:|.||.....|      ::.
Mosquito   587 AASDNGEEGGVGGSATKDADQEVEEEETVAHEAGE-GVETVQKVKQEVQEDTASVGEDREITIEG 650

  Fly   718 AKKAPAKLEPKAEDISEILTDVPV----DIS----TEAVEIIEEAEE--------------DTCS 760
            .|.....:|...|:..||..::||    ||:    .|.|:|.||.||              ||.|
Mosquito   651 VKVEEEPMEQDEEEEEEIGKELPVEEKMDITEEEVMECVKIKEEPEEDVAAVVLEEAKGDGDTSS 715

  Fly   761 NSSIKPGE--LRLDESNDEPELL--------------------------------------LEDA 785
            .:...|.:  ....|||..|:..                                      .:||
Mosquito   716 KTDHVPAKDANEAQESNRRPDSAGSAVDEEAGASRASSAGGAVVAPSDGEVSSSSTTSKTPTDDA 780

  Fly   786 ----------LIVNGDEN-------ETPDQPEEKEDQVEFFHTGEYDDFEHEIMVELAKEGVLDA 833
                      ...|||.|       .||:|...:....:...||.......:.............
Mosquito   781 SSPVPVASVPCKANGDSNGTTTGDQSTPNQQSSRTGGQQRPSTGATPKTASKSSSTPVAAATAST 845

  Fly   834 SGNALSQQKVELEHPEDVTLHESKNDIEAEES--------VERKPLKDPSVADEME---DMNEES 887
            :|........|.:.....|..:||.|.:..|.        ||.|..::...|:.:|   .:.||.
Mosquito   846 AGTLSPATGKESKPKTRTTKEKSKEDEKTREEKLRQEKLRVEEKVREEKQRAERLEAERRLKEEQ 910

  Fly   888 YIDIKDQTNQLLVEHLAEEAMEADC----GPEDNKENLSTSA---SSTAADGLD-----IQLAIK 940
              ..:.|..|.::|:..||...:..    ||:|.:|:.:.:|   :..|..||:     |.|..|
Mosquito   911 --QQQQQHQQQVLENGHEEEQPSPASGSGGPQDEQEHKTDTAPVPALLALGGLNLPAITIALTSK 973

  Fly   941 EDD---DEEKPLAVIADEQKPGLLLTNDMKVDEKPN------GKQESVCDE--HVQLVPNLRQEQ 994
            :||   ||::..|::..:.:..:|   .:|.|..|.      .|:|....|  .....|:|....
Mosquito   974 KDDGSSDEKEEAAIVPKKCELEIL---PIKADGGPPPAVVLLSKEEKPAKEGGAAAAAPSLADTA 1035

  Fly   995 E---------------------------------------------------------------- 995
            |                                                                
Mosquito  1036 ESRLRTASKGENAAASLSAVAERKDSSNKSSSPLTVLKQGTSNGSPSPPPATGKDAASTTTTTPP 1100

  Fly   996 ----------IHLQNLGLLTHQAAEHRRKCLLEAQARQAQMQLQQHHHHQHKRQGARGGGSATHV 1050
                      .||.||||||.:||:       |.:.|:|:.:.........:..|..||.|:   
Mosquito  1101 PDESDDAAKASHLLNLGLLTIRAAD-------EEKQRRAEQKPSSSADGGAQDGGTTGGNSS--- 1155

  Fly  1051 ESSGTLKTVIKLNRSSNGGVSGSGGLPTGTVIHGGCGSSSA--SSTSSSSVGSATRKSSGTLGSG 1113
             |.||            .|....|.|..||. |.|.||..|  .||.||.........:..|..|
Mosquito  1156 -SQGT------------AGKGSDGWLAAGTA-HSGGGSGRAGNKSTRSSKDEYTVSMKTTVLKGG 1206

  Fly  1114 AGAGAGVR-------RQSLKMTFQKGRARGHGAADRS------------ADQYGAHAEDSYYTIQ 1159
            :|:|:|.|       |..||||||||:.:|.|....:            |...|.:.::::||:.
Mosquito  1207 SGSGSGSRGEKRKQQRMPLKMTFQKGKGKGGGRESSNGSGSVSSNGSGYATDTGNNGDNTFYTVH 1271

  Fly  1160 NENEGAKKFVVTTGNT------GRKTNNRFSSTNNYHSTVALHGSNSALQYYSSHSESQGQTDHG 1218
            :..........:.|::      |||.::|..:|:..:.|.|:..|.|:                 
Mosquito  1272 SNELDHHSSNSSDGHSHRDAAGGRKAHSRSHTTDGVNLTEAVGESVSS----------------- 1319

  Fly  1219 FYQMVKKDEKEKILIPEKASSFKFHPGRLCEDQCYYCSGKFGLYDTPCHVGQIKSVERQQKI-LA 1282
                 |:..::.::||||||||..||.|||.|||.||.||||||||||||..|||.||||:| ||
Mosquito  1320 -----KEVSQKSLVIPEKASSFNVHPERLCRDQCSYCGGKFGLYDTPCHVAAIKSTERQQRILLA 1379

  Fly  1283 NEEKLTVDNCLCDACFRHVDRRANVPSYKKRLSASGHLEMGSAAGSALEKQFA------------ 1335
            ...|:|:|:||||||:|||||:||.|..||:.|........:.|.|:......            
Mosquito  1380 TLPKITLDSCLCDACYRHVDRKANCPPQKKKSSTVSQTSASTGAASSSSSSTTSTSTTNNNSTAT 1444

  Fly  1336 ----------------GDSGVITE---SGGEAGSTAAVAVQQRSCGVKDCVEAARHSLRRKCIRK 1381
                            |.:.:.||   :..|.|.||....:: .|.|:.|...|..|||||.:.|
Mosquito  1445 QSTVSPLVLKVTTNKDGSTSIATEQPATAMEDGPTAGGKARE-ICAVRQCTAHAMQSLRRKWMVK 1508

  Fly  1382 RVKKYQLSLEI------PAGSSNVGLCEAHYNTVIQFSGCVLCKRRLGKNHMYNITTQDTIRLEK 1440
            ..:|....|:|      .|.:..:.:|..||..:.....|.:|.:.|.:||:|:: ..:..:||:
Mosquito  1509 MKRKIGKQLDINLEQAAKATAEYISICNKHYEQISHLMICAMCTKPLQRNHVYHL-YNNVPQLER 1572

  Fly  1441 ALSEMGIPVQLGMG-TAVCKLCRYFANLLIKPPDSTKAQKAEFVKNYRKRLLKVHN--------- 1495
            .:.|.||.::|... ..|||||:|:||||||||: ||.:||:||.:|.:|||....         
Mosquito  1573 LIQEQGISMRLSSSELVVCKLCKYYANLLIKPPE-TKTKKAQFVNDYNRRLLCRQRAAEEQREQQ 1636

  Fly  1496 ----------------------------LQDGSHELSEADEEEAPNATETE-------------- 1518
                                        :.||..|..||::||....|.||              
Mosquito  1637 AEAAVTVTAVAPAAVPRQRQPMPVTDIVISDGDEEEEEAEDEEVEETTITESQSQQHPLPARYQT 1701

  Fly  1519 --------------RPTSDGHEDPEMPMVADYDGPTDSNSSSSSTAALDTSKQMSKLQAILQQNV 1569
                          |......:.|::.:| :.:|.|.. |.....:.:.|||.:|.|....||..
Mosquito  1702 LGDIFSIGDSSVSVRRRVSSRKSPDVTIV-ESNGATQM-SELEEISIIPTSKSLSALHQQQQQQS 1764

  Fly  1570 GADAAGAAGTGTVAASPGGSGSGADISNVLRGNPNISMRELFHGEEELGVQFKVPFGCSSSQRTP 1634
            ..|                   ..|::.||:.||||||||||.|||||||...:||. |||.|||
Mosquito  1765 RDD-------------------NIDMTQVLKSNPNISMRELFPGEEELGVHVNIPFS-SSSMRTP 1809

  Fly  1635 EGWTRVQTFLQYDEPTRRLWEELQKPYGNQSSFLRHLILLEKYYRNGDLVLAPHASSNATVYTET 1699
            ||||:||:.:|||:.||.|||||||||||||||||||:|||||:|||||||:|.|.::||.|:|.
Mosquito  1810 EGWTKVQSTIQYDDSTRALWEELQKPYGNQSSFLRHLLLLEKYFRNGDLVLSPQAKTSATTYSEA 1874

  Fly  1700 VRQRLNSFDHGHCGGLNIAGSPSSSGSGKRSGVPQPTGASVLATALTTPLTSHSSSSASISS--- 1761
            |:.||.|:|:                      ||....:|..|.|..||..:..:.:|..:|   
Mosquito  1875 VQNRLRSYDN----------------------VPSVVPSSPPALASLTPAATAPTVAADKTSHIF 1917

  Fly  1762 EQHSSVDPVIPLVDLNDDDEGEDGAGGAGERESTNRQQDVILECLRTASVDKLTKQLSSNAVTII 1826
            :|.||.  .|.:|..|.........||:...|.|.......:..|::.::     .|:::.....
Mosquito  1918 QQFSSA--TITIVPANKVRPRTSAGGGSSSAEITPVSPPAPVSLLKSNNL-----HLANSGDQGA 1975

  Fly  1827 ARPKDKSQLSCNSGSSTSISSSSSAISSPEEVAVTKVTAVAPVQSKDAPPLAPASSGVSNSRSIL 1891
            .:...|.:||..||..|  |..:|||:||...:.|.......|...|.|. ||.||         
Mosquito  1976 TKQSLKRKLSIESGGRT--SGGASAITSPLNSSSTVGGGSTKVVRLDEPK-APLSS--------- 2028

  Fly  1892 KTNLLGMNKAVELVPLTTAPHAYKPTGCHKPEKQQKILDVANKQPGSQGEPVPSSALLGLQSKLK 1956
            ...|:.::.....|.:||.|.|                             ...||.:|....:.
Mosquito  2029 PPELISISNRKASVTITTIPPA-----------------------------AAQSATVGSPPAVA 2064

  Fly  1957 PPTHQQQVSGSGAGTSGSQKPSNVAQLLSSPPELISLHRRQTSGAAAGSSSFLQGKRLQLPRSGA 2021
            ..|.|:|:|                 ||..|.:.:...........|.:::.|..|.   |.:||
Mosquito  2065 TATAQKQLS-----------------LLQQPQQSLLQSVAAVDAVTAAAATLLAKKS---PTAGA 2109

  Fly  2022 GPSGAGTGTG---AGAAGSRSAGGPPPPNVVI-LPDALTPQERHES--KSWKPTLIPLEDQHKVP 2080
            ..:.|.|.||   .|..||.:|........:| :|:.||..||.||  :.|:|||:|:.......
Mosquito  2110 TATTANTPTGPSSTGTTGSANASATTTAREIIQMPEQLTEAERRESSTRPWRPTLLPIAPGVSES 2174

  Fly  2081 NKSHALYQTADGRRLPALVQVQSGGKPYLISIFDYNRMCILRREKLMRDQLLKSNAKPKPQNQQQ 2145
            .|:..||||||||.||.||||.||||||.|||.|||||||||||||::.|          ||..|
Mosquito  2175 LKTGPLYQTADGRTLPKLVQVMSGGKPYHISIEDYNRMCILRREKLLQQQ----------QNMMQ 2229

  Fly  2146 QQGQTHQQQQNSAASAAAFSNMVKLAQQHTARQQLQQLQQKPQQQQQLPTLQP----------GG 2200
            ||    ||||.:.|:                ::|.|..|...|......||.|          |.
Mosquito  2230 QQ----QQQQQTVAN----------------KRQSQLPQPNKQPSAAATTLPPPPALRLASTAGS 2274

  Fly  2201 V------------------RLARLPQKL-----LMPPLTNPQIGSQAPNLQPLLSSTLDNS---N 2239
            |                  ::.:||.:|     |:|.|:.....::..|:|...|.|:..:   |
Mosquito  2275 VENNNGSANSVAVSVASSAKVVQLPNQLLEQNSLIPILSGSSGANKMGNVQKNSSLTVTMTTTVN 2339

  Fly  2240 NCWLWKNFPD------------------PNQ-----YLLNGNGGG-----AGSSSSKLP------ 2270
            |..|.|:...                  ||.     .|::.|...     |.||:..||      
Mosquito  2340 NNSLAKSSSSSSSSATATVPPSMKPLSLPNSTTVYPMLMSANTLSLPSLFATSSAGSLPVSSVAA 2404

  Fly  2271 ----------------HLTAKPATA------------TSSSGAANKSAGSLFTLKQQQH------ 2301
                            |..|..||:            |:||.:::.||.:...|...:|      
Mosquito  2405 LFSEVNAAMTQTSSPSHRPAPAATSLVLGQPTSLLTTTTSSSSSSASAATAAVLNPFEHLFKDGN 2469

  Fly  2302 ---------------------QQKLIDNA----IMSKIPKSLTVIPQQ 2324
                                 ...|:||:    ::|||||||||||||
Mosquito  2470 KVTQAQLQEFVAIATAANGGGSSSLLDNSSPAQLLSKIPKSLTVIPQQ 2517

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