Protein Alignment scw and GDF15

DIOPT Version :9

• Sequence 1: NP_001286088.1
• Gene: scw / 46000
• FlyBaseID: FBgn0005590
• Length: 400
• Species: Drosophila melanogaster
• Sequence 2: NP_004855.2
• Gene: GDF15 / 9518
• HGNCID: 30142
• Length: 308
• Species: Homo sapiens
• Alignment Length: 224
• Identity: 58/224 - (25%)
• Similarity: 94/224 - (41%)
• Gaps: 43/224 - (19%)

  Fly   182 YRILGSVNTTSSQRGWLEFNLTDTLRYWLHNKGLQRRN----ELRISIGDSQLSTFAAGLVTPQA 242
            :|.|..::.|:| |.|   ::|..||..|   .|.|..    .||:|...||.....       |
Human   121 HRALFRLSPTAS-RSW---DVTRPLRRQL---SLARPQAPALHLRLSPPPSQSDQLL-------A 171

  Fly   243 SRTSLEPFIVGYFNGPELLVKIQKLRFKRDLEKRRAGGGSPPPPPPPPVDLYRPPQSCERLNFTV 307
            ..:|..|.:       ||.::.|..|.:|   :.||..|...|        ..|.:.|.......
Human   172 ESSSARPQL-------ELHLRPQAARGRR---RARARNGDHCP--------LGPGRCCRLHTVRA 218

  Fly   308 DFKELHMHNWVIAPKKFEAYFCGGGCNFPLGTKMNATN-HAIVQTLMH-LKQPHLPKPCCVPTVL 370
            ..::|...:||::|::.:...|.|.|    .::..|.| ||.::|.:| ||...:|.|||||...
Human   219 SLEDLGWADWVLSPREVQVTMCIGAC----PSQFRAANMHAQIKTSLHRLKPDTVPAPCCVPASY 279

  Fly   371 GAITILRYLNEDIIDLTKYQKAVAKECGC 399
            ..:.:::..:.. :.|..|...:||:|.|
Human   280 NPMVLIQKTDTG-VSLQTYDDLLAKDCHC 307

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
scw	NP_001286088.1	TGFb_propeptide	39..254	CDD:279078	20/75 (27%)
		TGFB	300..400	CDD:214556	28/102 (27%)
GDF15	NP_004855.2	MscS_TM	<23..>147	CDD:331130	10/32 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	152..177		7/31 (23%)
		TGFB	211..308	CDD:214556	28/102 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810