Protein Alignment scw and TGFB3

DIOPT Version :10

• Sequence 1: NP_524863.3
• Gene: scw / 46000
• FlyBaseID: FBgn0005590
• Length: 400
• Species: Drosophila melanogaster
• Sequence 2: NP_003230.1
• Gene: TGFB3 / 7043
• HGNCID: 11769
• Length: 412
• Species: Homo sapiens
• Alignment Length: 461
• Identity: 108/461 - (23%)
• Similarity: 177/461 - (38%)
• Gaps: 125/461 - (27%)

  Fly     1 MLNVFFLTSLFYAASATTYVTTN-NHIEMPIYQKRPLSEQMEMIDILDLGDRPRRQAEPN----- 59
            :|| |...||    |.:|..|.: .||:    :||..:.:.:::..|.|...|    ||.
Human    14 LLN-FATVSL----SLSTCTTLDFGHIK----KKRVEAIRGQILSKLRLTSPP----EPTVMTHV 65

  Fly    60 ------LHNSASKFLLEVYNE-----ISEDQEPKEVLHQRHKRSLDDDILISNEDRQEIASCNSI 113
                  |:||..:.|.|::.|     ..|:.|.:....:.||    .|::....:..|:|.|
Human    66 PYQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHK----FDMIQGLAEHNELAVC--- 123

  Fly   114 LTFSSRLKPEQLDNELDMHITFNTNDVPVD-LSLVQAMLRIYKQPSLVDRRANFTVSVYRKLDNR 177
                    |:.:.:::   ..||.:.|..: .:|.:|..|:.:.|:...:|....:.:::.|  |
Human   124 --------PKGITSKV---FRFNVSSVEKNRTNLFRAEFRVLRVPNPSSKRNEQRIELFQIL--R 175

  Fly   178 QD---FSYRILGSVN-TTSSQRGWLEFNLTDTLRYWLHNKGLQRRNELRISIG-DSQLSTFAAGL 237
            .|   ...|.:|..| .|.....||.|::|||:|.||    |:|.:.|.:.|. .....||
Human   176 PDEHIAKQRYIGGKNLPTRGTAEWLSFDVTDTVREWL----LRRESNLGLEISIHCPCHTF---- 232

  Fly   238 VTPQASRTSLEPFIVGYFNGP--ELLVKIQKLRFK----------RDLEKRRAGGGSPPPP---- 286
                      :|      ||.  |.:.::.:::||          .||.:.:.......|.
Human   233 ----------QP------NGDILENIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPHLILM 281

  Fly   287 --PPPPVDLYRPPQSCER------LNFT--------------VDFKELHMHNWVIAPKKFEAYFC 329
              ||..:|  .|.|..:|      .|:.              :||::.....||..||.:.|.||
Human   282 MIPPHRLD--NPGQGGQRKKRALDTNYCFRNLEENCCVRPLYIDFRQDLGWKWVHEPKGYYANFC 344

  Fly   330 GGGCNFPLGTKMNATNHAIVQTLMHLKQPHL-PKPCCVPTVLGAITILRYLNEDIIDLTKYQKAV 393
            .|.|.:   .:...|.|:.|..|.:...|.. ..|||||..|..:|||.|:.. ...:.:....|
Human   345 SGPCPY---LRSADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYYVGR-TPKVEQLSNMV 405

  Fly   394 AKECGC 399
            .|.|.|
Human   406 VKSCKC 411

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
scw	NP_524863.3	TGFb_propeptide	39..254	CDD:480997	51/236 (22%)
		TGF_beta_BMP5_like	299..400	CDD:381639	32/122 (26%)
TGFB3	NP_003230.1	TGFb_propeptide	24..231	CDD:459906	54/238 (23%)
		Cell attachment site. /evidence=ECO:0000250|UniProtKB:P01137	261..263		0/1 (0%)
		TGF_beta_TGFB3	312..412	CDD:381656	30/104 (29%)