Protein Alignment scw and TGFB2

DIOPT Version :9

• Sequence 1: NP_001286088.1
• Gene: scw / 46000
• FlyBaseID: FBgn0005590
• Length: 400
• Species: Drosophila melanogaster
• Sequence 2: NP_001129071.1
• Gene: TGFB2 / 7042
• HGNCID: 11768
• Length: 442
• Species: Homo sapiens
• Alignment Length: 459
• Identity: 97/459 - (21%)
• Similarity: 174/459 - (37%)
• Gaps: 82/459 - (17%)

  Fly     1 MLNVFFLTSLFYAASATTYVTTNNHIEMPIY-QKRPLSEQMEMIDILDLGDRPRRQAEP------ 58
            :|:.|.:..|...|.:   ::|.:.::|..: :||..:.:.:::..|.|...|....||
Human     5 VLSAFLILHLVTVALS---LSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPEEVPPE 66

  Fly    59 --NLHNSASKFLLEVYNE---ISEDQEPKEVLHQRHKRSLDDDILISNEDRQEIAS--CNSILTF 116
              :::||....|.|..:.   ..|.:...|..:.:....:|......:|....:.:  ..|:.:.
Human    67 VISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSETVCPVVTTPSGSVGSL 131

  Fly   117 SSRLKPEQLDNELD-----------MHITFNTNDVPVDLS-LVQAMLRIYKQPSLVDRRANFTVS 169
            .|| :.:.|...||           ..:.|:.:.:..:.| ||:|..|:::..:...|.....:.
Human   132 CSR-QSQVLCGYLDAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQRIE 195

  Fly   170 VYRKLDNRQDFS--YRILGS-VNTTSSQRGWLEFNLTDTLRYWLHNKGLQRRNELRISIGDSQLS 231
            :|:.|.::...|  .|.:.| |..|.::..||.|::||.:..|||:|  .|....:||: .....
Human   196 LYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHK--DRNLGFKISL-HCPCC 257

  Fly   232 TF--AAGLVTPQASRTSLEPFIVG------YFNGPELLVKIQKLRFKRDLEKRRAGGGSPPPPPP 288
            ||  :...:.|..|. .||....|      |.:|.:..:|          ..|:...|..|....
Human   258 TFVPSNNYIIPNKSE-ELEARFAGIDGTSTYTSGDQKTIK----------STRKKNSGKTPHLLL 311

  Fly   289 PPVDLYR----------------------PPQSCERLNFTVDFKELHMHNWVIAPKKFEAYFCGG 331
            ..:..||                      ...:|......:|||......|:..||.:.|.||.|
Human   312 MLLPSYRLESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAG 376

  Fly   332 GCNFPLGTKMNATNHAIVQTLMHLKQPHL-PKPCCVPTVLGAITILRYLNEDIIDLTKYQKAVAK 395
            .|.:...:.   |.|:.|.:|.:...|.. ..||||...|..:|||.|:.: ...:.:....:.|
Human   377 ACPYLWSSD---TQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGK-TPKIEQLSNMIVK 437

  Fly   396 ECGC 399
            .|.|
Human   438 SCKC 441

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
scw	NP_001286088.1	TGFb_propeptide	39..254	CDD:279078	52/250 (21%)
		TGFB	300..400	CDD:214556	29/101 (29%)
TGFB2	NP_001129071.1	TGFb_propeptide	21..256	CDD:395559	49/238 (21%)
		TGF_beta_TGFB2	345..441	CDD:381655	28/99 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810