DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scw and BMP3

DIOPT Version :9

Sequence 1:	NP_001286088.1	Gene:	scw / 46000	FlyBaseID:	FBgn0005590	Length:	400	Species:	Drosophila melanogaster
Sequence 2:	NP_001192.4	Gene:	BMP3 / 651	HGNCID:	1070	Length:	472	Species:	Homo sapiens

Alignment Length:	438	Identity:	100/438 - (22%)
Similarity:	164/438 - (37%)	Gaps:	119/438 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LNVFFLTSLFYA---ASATTYVTT----NNHIEMPIYQKRPLSEQMEMIDILDLG------DRPR 53
            |.:|.||||..:   .|||.|...    |..:..|:........|.:.|.| ||.      .|.:
Human   113 LYIFNLTSLTKSENILSATLYFCIGELGNISLSCPVSGGCSHHAQRKHIQI-DLSAWTLKFSRNQ 176

  Fly    54 RQAEPNLHNSASKFLLEVYNEISED--------QEPKEVL---------HQRHKRSL---DDDIL 98
            .|...:|....:|...::.:.:|:|        :|.:|.|         .|..||.|   :..||
Human   177 SQLLGHLSVDMAKSHRDIMSWLSKDITQLLRKAKENEEFLIGFNITSKGRQLPKRRLPFPEPYIL 241

  Fly    99 ISNEDRQEIASCNSILTFSSRLKPEQLDNELDMHITFNTNDVPVDLSLVQAMLRIYKQPSLVDRR 163
            :...|             ::..:||.:.:.|..|..|.|..||...|.::|.|.|       :||
Human   242 VYAND-------------AAISEPESVVSSLQGHRNFPTGTVPKWDSHIRAALSI-------ERR 286

  Fly   164 ANFTVSVYRKLDNRQ----DFSYRILGSVNTTSSQRGWLEFNLTDTLRYWLHNKGLQRRNELRIS 224
            ...:..|...|.|.:    ::.|:         ....|.|.....||:.....|...::.:.:
Human   287 KKRSTGVLLPLQNNELPGAEYQYK---------KDEVWEERKPYKTLQAQAPEKSKNKKKQRK-- 340

  Fly   225 IGDSQLSTFAAGLVTPQASRTSLEPFIVGYFNGPELLVKIQKLRF-KRDLEKRRAGGGSPPPPPP 288
                                            ||..  |.|.|:| ::.|:|.|.
Human   341 --------------------------------GPHR--KSQTLQFDEQTLKKARR---------- 361

  Fly   289 PPVDLYRPPQSCERLNFTVDFKELHMHNWVIAPKKFEAYFCGGGCNFPLGTKMNATNHAIVQTLM 353
               ..:..|::|.|....|||.::....|:|:||.|:||:|.|.|.||:...:..:|||.:|:::
Human   362 ---KQWIEPRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIV 423

  Fly   354 HL--KQPHLPKPCCVPTVLGAITILRYLNEDIIDLTKYQKAVAKECGC 399
            ..  ..|.:|:|||||..:.:::||.:.....:.|..|.....:.|.|
Human   424 RAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCAC 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scw	NP_001286088.1	TGFb_propeptide	39..254	CDD:279078	44/244 (18%)
scw	NP_001286088.1	TGFB	300..400	CDD:214556	34/102 (33%)
BMP3	NP_001192.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	27..53
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	320..350		7/65 (11%)
		TGF_beta_BMP3	363..472	CDD:381663	35/109 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810