Protein Alignment scw and Tgfb1

DIOPT Version :10

• Sequence 1: NP_524863.3
• Gene: scw / 46000
• FlyBaseID: FBgn0005590
• Length: 400
• Species: Drosophila melanogaster
• Sequence 2: NP_067589.1
• Gene: Tgfb1 / 59086
• RGDID: 69051
• Length: 390
• Species: Rattus norvegicus
• Alignment Length: 426
• Identity: 89/426 - (20%)
• Similarity: 161/426 - (37%)
• Gaps: 102/426 - (23%)

  Fly    13 AASATTYVTTNNHIEMPIYQKRPLSE-QMEMIDILDLGDRPRRQAEPNLHNSASKFLLEVYNEI- 75
            ||..:|..|    |:|.:.:::.:.. :.:::..|.|...|.:...|  .....:.:|.:||..
  Rat    27 AAGLSTCKT----IDMELVKRKRIEAIRGQILSKLRLASPPSQGEVP--PGPLPEAVLALYNSTR 85

  Fly    76 ------SEDQEPKEVLHQRHKRSLDDDILISNEDRQEIASCNSILTFSSRLKPEQLDNELDMHIT 134
                  |.|.||:.          :.|.......|..:...|:.:...::      |....:::.
  Rat    86 DRVAGESADPEPEP----------EADYYAKEVTRVLMVDRNNAIYDKTK------DITHSIYMF 134

  Fly   135 FNTND----VPVDLSLVQAMLRIYKQPSLVDRRANFTVSVYRKLDNRQDFSYRILGS-VNTTSSQ 194
            |||:|    ||....|.:|.||:.:..|.|::.    |.:|:|..|.   |:|.||: :.|.:..
  Rat   135 FNTSDIREAVPEPPLLSRAELRLQRFKSTVEQH----VELYQKYSNN---SWRYLGNRLLTPTDT 192

  Fly   195 RGWLEFNLTDTLRYWLH-NKGLQ------------RRNELRISIGDSQLSTFAAGLVTPQASRTS 246
            ..||.|::|..:|.||: ..|:|            :.|.|.:.|..          ::|: .|..
  Rat   193 PEWLSFDVTGVVRQWLNQGDGIQGFRFSAHCSCDSKDNVLHVEING----------ISPK-RRGD 246

  Fly   247 L-------EPFIVGYFNGPELLVKIQKLRFKRDLEKRRAGGGSPPPPPPPPVDLYRPPQSCERLN 304
            |       .||::......|....:...|.:|.|:.......:              .::|....
  Rat   247 LGTIHDMNRPFLLLMATPLERAQHLHSSRHRRALDTNYCFSST--------------EKNCCVRQ 297

  Fly   305 FTVDFKELHMHNWVIAPKKFEAYFCGGGCNF--PLGTKMNATNHAIVQTLMHLKQPHLP----KP 363
            ..:||::.....|:..||.:.|.||.|.|.:  .|.|:.:        .::.|...|.|    .|
  Rat   298 LYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYS--------KVLALYNQHNPGASASP 354

  Fly   364 CCVPTVLGAITILRYLNEDIIDLTKYQKAVAKECGC 399
            ||||..|..:.|:.|:... ..:.:....:.:.|.|
  Rat   355 CCVPQALEPLPIVYYVGRK-PKVEQLSNMIVRSCKC 389

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
scw	NP_524863.3	TGFb_propeptide	39..254	CDD:480997	53/246 (22%)
		TGF_beta_BMP5_like	299..400	CDD:381639	26/107 (24%)
Tgfb1	NP_067589.1	TGFb_propeptide	30..261	CDD:459906	57/270 (21%)
		Straightjacket domain. /evidence=ECO:0000250|UniProtKB:P07200	30..74		8/49 (16%)
		Arm domain. /evidence=ECO:0000250|UniProtKB:P07200	75..271		50/229 (22%)
		Bowtie tail. /evidence=ECO:0000250|UniProtKB:P01137	226..252		6/36 (17%)
		Cell attachment site. /evidence=ECO:0000255	244..246		1/1 (100%)
		TGF_beta_TGFB1	292..390	CDD:381654	26/107 (24%)