Protein Alignment scw and GDF6

DIOPT Version :9

• Sequence 1: NP_001286088.1
• Gene: scw / 46000
• FlyBaseID: FBgn0005590
• Length: 400
• Species: Drosophila melanogaster
• Sequence 2: NP_001001557.1
• Gene: GDF6 / 392255
• HGNCID: 4221
• Length: 455
• Species: Homo sapiens
• Alignment Length: 511
• Identity: 115/511 - (22%)
• Similarity: 171/511 - (33%)
• Gaps: 175/511 - (34%)

  Fly     1 MLNVFFLTSLFYAASATTYVTTNNHIEMPIYQKRPLSEQMEMIDI-------------------- 45
            :|:..||.|..:              ::|.:|:..:|......::
Human     7 LLSAVFLISFLW--------------DLPGFQQASISSSSSSAELGSTKGMRSRKEGKMQRAPRD 57

  Fly    46 LDLG-----DRPRRQAEPNLHNSAS-------------KFLLEVYNEISEDQEPKEVLHQRHKRS 92
            .|.|     .:||.|.||......:             :::|.:|...                |
Human    58 SDAGREGQEPQPRPQDEPRAQQPRAQEPPGRGPRVVPHEYMLSIYRTY----------------S 106

  Fly    93 LDDDILISNEDRQEIASCNSILTFSSRLKPEQLDNELD--MHITFNTNDVPVDLS-------LVQ 148
            :.:.:.|:....|...|.|:|.:|        :|..||  .|..........|:|       ||.
Human   107 IAEKLGINASFFQSSKSANTITSF--------VDRGLDDLSHTPLRRQKYLFDVSMLSDKEELVG 163

  Fly   149 AMLRIYKQ----------------------PSLVDRRANFTVSVYRKLDNRQDFSYRILGSVNTT 191
            |.||:::|                      |.|:|.|.         ||.:             .
Human   164 AELRLFRQAPSAPWGPPAGPLHVQLFPCLSPLLLDART---------LDPQ-------------G 206

  Fly   192 SSQRGWLEFNLTDTLRYWLHNKGLQRRNELRISIGDSQLSTFAAGLVTP-QASRTSLEPFIVGYF 255
            :...||..|::...||   |....|...|||.:.|:.......|....| |.....|.....|..
Human   207 APPAGWEVFDVWQGLR---HQPWKQLCLELRAAWGELDAGEAEARARGPQQPPPPDLRSLGFGRR 268

  Fly   256 NGP----ELLVKIQKLRFKRDLEKRR--------AGGGS------PPPPPPPPVDLYRPPQS--- 299
            ..|    .|||...:.:.|....:.|        ||.|:      |||...|....:.|...
Human   269 VRPPQERALLVVFTRSQRKNLFAEMREQLGSAEAAGPGAGAEGSWPPPSGAPDARPWLPSPGRRR 333

  Fly   300 --------------------CERLNFTVDFKELHMHNWVIAPKKFEAYFCGGGCNFPLGTKMNAT 344
                                |.:....|:||||...:|:|||.::|||.|.|.|:|||.:.:..|
Human   334 RRTAFASRHGKRHGKKSRLRCSKKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDFPLRSHLEPT 398

  Fly   345 NHAIVQTLMHLKQP-HLPKPCCVPTVLGAITILRYLNEDIIDLTKYQKAVAKECGC 399
            ||||:||||:...| ..|..|||||.|..|:||.....:.:...:|:..|.:.|||
Human   399 NHAIIQTLMNSMDPGSTPPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVVESCGC 454

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
scw	NP_001286088.1	TGFb_propeptide	39..254	CDD:279078	49/284 (17%)
		TGFB	300..400	CDD:214556	44/101 (44%)
GDF6	NP_001001557.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	29..93		8/63 (13%)
		TGFb_propeptide	79..281	CDD:395559	47/250 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	244..267		4/22 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	300..351		8/50 (16%)
		TGF_beta_GDF5_6_7	354..455	CDD:381644	44/101 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810