Protein Alignment scw and Lefty2

DIOPT Version :10

• Sequence 1: NP_524863.3
• Gene: scw / 46000
• FlyBaseID: FBgn0005590
• Length: 400
• Species: Drosophila melanogaster
• Sequence 2: NP_796073.1
• Gene: Lefty2 / 320202
• MGIID: 2443573
• Length: 368
• Species: Mus musculus
• Alignment Length: 215
• Identity: 53/215 - (24%)
• Similarity: 92/215 - (42%)
• Gaps: 43/215 - (20%)

  Fly   140 VPVDLSLVQAMLRIYKQP------------SLVDRRANFTVSVYRKLDNRQDFSYR--ILGSVNT 190
            :|.:..||||:||::::|            |....||..|:...|.   |:|.|.|  ::.|...
Mouse   107 LPPNSELVQAVLRLFQEPVPRTALRRFERLSPHSARARVTIEWLRV---REDGSNRTALIDSRLV 168

  Fly   191 TSSQRGWLEFNLTDTLRYWLHNKGLQRRNE---LRISIGDSQL--STFAAGLVTPQASRTSLEPF 250
            :..:.||..|::|:.:.:|   :.|.|..:   |::|:....|  .|::|..:...|::.:.:
Mouse   169 SIHESGWKAFDVTEAVNFW---QQLSRPRQPLLLQVSVQREHLGPGTWSAHKLVRFAAQGTPD-- 228

  Fly   251 IVGYFNG-PELLVKIQKLRFKRDLEKRRAGGGSPPPPPPPPVDLYRPPQSCERLNFTVDFKELH- 313
              |...| |:|  ::..|    ||:...|.|...|..|      ......|.|....:|.:.:.
Mouse   229 --GKGQGEPQL--ELHTL----DLKDYGAQGNCDPEVP------VTEGTRCCRQEMYLDLQGMKW 279

  Fly   314 MHNWVIAPKKFEAYFCGGGC 333
            ..||::.|..|..|.|.|.|
Mouse   280 AENWILEPPGFLTYECVGSC 299

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
scw	NP_524863.3	TGFb_propeptide	39..254	CDD:480997	31/132 (23%)
		TGF_beta_BMP5_like	299..400	CDD:381639	11/36 (31%)
Lefty2	NP_796073.1	TGFb_propeptide	<106..203	CDD:480997	26/101 (26%)
		TGF_beta_LEFTY1_2	264..355	CDD:381636	11/36 (31%)