DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scw and bmp7a

DIOPT Version :9

Sequence 1:	NP_001286088.1	Gene:	scw / 46000	FlyBaseID:	FBgn0005590	Length:	400	Species:	Drosophila melanogaster
Sequence 2:	NP_571396.1	Gene:	bmp7a / 30584	ZFINID:	ZDB-GENE-000208-25	Length:	432	Species:	Danio rerio

Alignment Length:	444	Identity:	127/444 - (28%)
Similarity:	213/444 - (47%)	Gaps:	60/444 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLNVFFLTSLFYAASATTYV-------TTNNHIEMPIYQKRPLSE-----QMEMIDILDLGDRPR 53
            |..|..:::|..|...:...       |.:|.|:....|:|..|:     |.|::.||.|..|||
Zfish     5 MFPVHLISTLIVACGCSVLADAMQANFTMDNDIQSSFIQRRLKSQERREMQREILSILGLPQRPR 69

  Fly    54 RQAEPNL---HNSASKFLLEVYNEISEDQEPKEVLHQRHK--RSLDDDILISNEDRQEIASCNSI 113
                |.|   |.:|..::|::||.|.||.:.:..|...::  .:.....|::.:|.:.::..:.:
Zfish    70 ----PLLHERHTAAPMYMLDLYNAILEDGDRRGGLVYSYEPAYTTPGPPLVTQQDSRFLSDADMV 130

  Fly   114 LTFSSRLKPE---QLDNELDMHITFNTNDVPVDLSLVQAMLRIYKQPSLVDRRAN--FTVSVYRK 173
            ::|::.:.||   ||.::......|:.:.:|...::..|..||||. .:.:|..|  |.|||::.
Zfish   131 MSFANTVDPEEDLQLYHQHRREFRFDLSRIPPGETVTAAEFRIYKD-FVRERYENETFHVSVFQV 194

  Fly   174 LDNRQDFSYRILGSVNTTSSQRGWLEFNLTDTLRYWLHNKGLQRRNELRISIG-DSQLSTFAAGL 237
            |..:......:|.|....:::.|||.|:||.|..:|:.|.|.....:|.:... .::::...|||
Zfish   195 LQQQHRRELYLLDSRVVWAAEEGWLVFDLTVTSNHWVINPGQNLGLQLLVETSHGARMNPRRAGL 259

  Fly   238 VTPQASRTSLEPFIVGYFNGPELLVKIQKLRFKRDLEKRRAGGG----------SPPPPPPPPVD 292
            |....::.. :||:|.:.....:.::          ..|.|.||          :.|......|.
Zfish   260 VGSSGAQNK-QPFMVAFLKASGIHLR----------SVRSASGGKQKGHHRTKNAKPGAAHSQVA 313

  Fly   293 L----------YRPPQSCERLNFTVDFKELHMHNWVIAPKKFEAYFCGGGCNFPLGTKMNATNHA 347
            |          ..|.|.|::....|.|::|...:|:|||:.:.||:|.|.|.|||.:.|||||||
Zfish   314 LKTAEATEGASIDPKQGCKKHELYVSFRDLGWQDWIIAPEGYAAYYCEGECVFPLNSYMNATNHA 378

  Fly   348 IVQTLMHLKQPH-LPKPCCVPTVLGAITILRYLNEDIIDLTKYQKAVAKECGCH 400
            |||||:|...|. :|||||.||.|..|::|.:.:...:.|.||:..|.:.||||
Zfish   379 IVQTLVHFINPETVPKPCCAPTQLHGISVLYFDDSSNVILKKYRNMVVRACGCH 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scw	NP_001286088.1	TGFb_propeptide	39..254	CDD:279078	60/225 (27%)
scw	NP_001286088.1	TGFB	300..400	CDD:214556	46/100 (46%)
bmp7a	NP_571396.1	TGFb_propeptide	34..275	CDD:279078	65/246 (26%)
bmp7a	NP_571396.1	TGF_beta	329..431	CDD:278448	46/101 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1063560at2759
OrthoFinder	1	1.000	-	-		FOG0000576
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11848
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X157
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.880