Protein Alignment scw and lft2

DIOPT Version :10

• Sequence 1: NP_524863.3
• Gene: scw / 46000
• FlyBaseID: FBgn0005590
• Length: 400
• Species: Drosophila melanogaster
• Sequence 2: NP_571036.1
• Gene: lft2 / 30146
• ZFINID: ZDB-GENE-990630-11
• Length: 362
• Species: Danio rerio
• Alignment Length: 445
• Identity: 91/445 - (20%)
• Similarity: 164/445 - (36%)
• Gaps: 142/445 - (31%)

  Fly     2 LNVFFLTSLFYAASATTYVTTNNHIEMPIYQKRPLSEQMEMIDILDLGDRPRRQAEPNLHNSA-- 64
            :.:|.||:    |.:.|....:..|:..:.||..|:|             |.|..:.:|.|..
Zfish     5 IQLFILTT----AISLTQGFQHEDIKQALLQKLGLTE-------------PPRIQKRDLENLVVP 52

  Fly    65 ----SKFL--LEVYNEISEDQEPKEVLHQRHKRSLDD----------------DILISNEDRQEI 107
                ||:|  |:::             |||.:|||..                :|..|:..||.:
Zfish    53 AHIKSKYLSMLKLH-------------HQRRRRSLPSLAGILRGIHGNADITGEIKYSDTTRQRL 104

  Fly   108 ASCNSILTFSSRLKPEQLDNELDMHITFNTNDVPVDLSLVQAMLRIYKQPSLVDRR-----ANFT 167
                 :....:||:.             ||.....:|.|.|...   :.||..:||     .:..
Zfish   105 -----VFDMEARLQE-------------NTEVTMAELKLFQTAA---QSPSKPERRHHRPINHAR 148

  Fly   168 VSVY--RKLDNRQDFSYRILGSVNTTSSQRGWLEFNLTDTLRYWLHNKGLQRRNELRISI---GD 227
            ||:|  ..|:|..:.: .:|.|......:.||..|::|..:.||..:   |::..|.:.:   |:
Zfish   149 VSIYWVEVLENGSNRT-SLLDSRLVPIHESGWRSFDVTQAIHYWSKS---QKKAPLHLEVWTEGE 209

  Fly   228 SQLSTFAAGL------VTPQASRTSLEPFIVGYFNGPELLVKIQKLRFKRDLEKRRAGGGSPPPP 286
             :..::||.:      .|......:||..:    ..|||::      :..||::..:.|.....|
Zfish   210 -RPGSYAAEMAKRVRFATQDPKENTLEKDM----GAPELVL------YTLDLDEYGSQGNCNSSP 263

  Fly   287 PPPPVDLYRPPQSCERLNFTVDFKEL-HMHNWVIAPKKFEAYFCGGGCNFP------LGTKMNAT 344
                    ...:.|...:| ::|:|| ....|:|.|..::|:.|.|||..|      .|.:..|.
Zfish   264 --------NSSKCCREEHF-INFRELTWTQYWIIEPAGYQAFRCAGGCKQPKRGFYGYGQRTCAV 319

  Fly   345 NHAIVQTLMHLKQPHLPKPCCVPTVLGAITILRYLNEDIIDLTKYQKAVAKECGC 399
            ..:....:|:|.:.            |..|        .|::.::...:.::|||
Zfish   320 MESAPLPMMYLVKK------------GDYT--------EIEVAEFPNMIVEKCGC 354

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
scw	NP_524863.3	TGFb_propeptide	39..254	CDD:480997	50/254 (20%)
		TGF_beta_BMP5_like	299..400	CDD:381639	24/108 (22%)
lft2	NP_571036.1	TGFb_propeptide	23..>191	CDD:480997	45/215 (21%)
		TGF_beta_LEFTY1_2	267..354	CDD:381636	22/107 (21%)