Protein Alignment scw and GDF2

DIOPT Version :9

• Sequence 1: NP_001286088.1
• Gene: scw / 46000
• FlyBaseID: FBgn0005590
• Length: 400
• Species: Drosophila melanogaster
• Sequence 2: NP_057288.1
• Gene: GDF2 / 2658
• HGNCID: 4217
• Length: 429
• Species: Homo sapiens
• Alignment Length: 427
• Identity: 95/427 - (22%)
• Similarity: 160/427 - (37%)
• Gaps: 127/427 - (29%)

  Fly    39 QMEMIDILDLGDRP---RRQAEPNLHNSASKFLLEVYNEISEDQEPKEVLHQRHKRSLDDDILIS 100
            :::.:..|:|...|   :.:.||      .::::::||..:.|:......:.....|::|.|.|:
Human    63 KVDFLRSLNLSGVPSQDKTRVEP------PQYMIDLYNRYTSDKSTTPASNIVRSFSMEDAISIT 121

  Fly   101 NEDRQEIASCNSILTFSSRLKPEQLDNELDMHITFNTNDVPVDLSLVQAMLRIYKQPSLVDRRAN 165
            ..:                      |.....||......:|....:.:|.||:|
Human   122 ATE----------------------DFPFQKHILLFNISIPRHEQITRAELRLY----------- 153

  Fly   166 FTVSVYRKLDNRQDFS-----YRILGSVNTTSS--------------QRGWLEFNLTDTLRYWLH 211
              ||....:|...|..     |.:|...:...|              ..||....::..::.|:.
Human   154 --VSCQNHVDPSHDLKGSVVIYDVLDGTDAWDSATETKTFLVSQDIQDEGWETLEVSSAVKRWVR 216

  Fly   212 NKGLQRRNELRISIGDSQLSTFAAGLVTPQASRTSLEPFIVGYFNGPELLVKIQKLRFKRDL--- 273
            :...:.:|:|.:::...:.......:..|..||..  ||.|.:.|......|..:|..:..:
Human   217 SDSTKSKNKLEVTVESHRKGCDTLDISVPPGSRNL--PFFVVFSNDHSSGTKETRLELREMISHE 279

  Fly   274 -------------------------------------EKRRAGGGSPPPPPPPPVDLYRPPQSCE 301
                                                 .||.||.||                .|:
Human   280 QESVLKKLSKDGSTEAGESSHEEDTDGHVAAGSTLARRKRSAGAGS----------------HCQ 328

  Fly   302 RLNFTVDFKELHMHNWVIAPKKFEAYFCGGGCNFPLGTKMNATNHAIVQTLMHLKQP-HLPKPCC 365
            :.:..|:|:::...:|:||||::|||.|.|||.|||...:..|.|||||||:|||.| .:.|.||
Human   329 KTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPTKVGKACC 393

  Fly   366 VPTVLGAITILRYLNEDIIDLTKYQ---KAVAKECGC 399
            |||.|..|::| |.::..:...||.   .:|| ||||
Human   394 VPTKLSPISVL-YKDDMGVPTLKYHYEGMSVA-ECGC 428

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
scw	NP_001286088.1	TGFb_propeptide	39..254	CDD:279078	38/236 (16%)
		TGFB	300..400	CDD:214556	48/104 (46%)
GDF2	NP_057288.1	TGFb_propeptide	76..257	CDD:279078	36/223 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	283..308		0/24 (0%)
		TGF_beta	326..428	CDD:278448	46/103 (45%)
		Interaction with ENG. /evidence=ECO:0000269|PubMed:28564608	402..416		2/14 (14%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810