Protein Alignment scw and Gdf6

DIOPT Version :10

• Sequence 1: NP_524863.3
• Gene: scw / 46000
• FlyBaseID: FBgn0005590
• Length: 400
• Species: Drosophila melanogaster
• Sequence 2: NP_001013056.1
• Gene: Gdf6 / 252834
• RGDID: 620104
• Length: 452
• Species: Rattus norvegicus
• Alignment Length: 495
• Identity: 122/495 - (24%)
• Similarity: 175/495 - (35%)
• Gaps: 146/495 - (29%)

  Fly     1 MLNVFFLTSLFYAASATTYVTTNNHIEMPIYQKRPL--SEQMEMIDILDLGDR--------PRRQ 55
            :|...||.|..:              ::|.:|:..:  |...|:....|:.:|        |:..
  Rat     7 LLWAIFLISFLW--------------DLPGFQQASISSSSSTELDSTKDVENRKGGKMQRTPQES 57

  Fly    56 AE---PNLHNSASKFLLEVYNEISEDQE-----PKEVLHQ-----RHKRSLDDDILISNEDRQEI 107
            ||   |..|......|.......|..||     |:.|.|:     ....|:.:.:.|:....|..
  Rat    58 AEGRTPKEHRPRPNELRRRLPGQSLGQEPPGRGPRVVPHEYMLSIYRTYSIAEKLGINASFFQSS 122

  Fly   108 ASCNSILTFSSRLKPEQLDNELD--MHITFNTNDVPVDLS-------LVQAMLRIYKQ------- 156
            .|.|:|.:|        :|..||  .|..........|:|       ||.|.||:|:|
  Rat   123 KSANTITSF--------VDRGLDDLSHTPLRRQKYLFDVSTLSDKEELVGAELRLYRQAPPTPWG 179

  Fly   157 ---------------PSLVDRRANFTVSVYRKLDNRQDFSYRILGSVNTTSSQRGWLEFNLTDTL 206
                           |.|:|.|.         ||.:             ..::.||..|::...|
  Rat   180 PQTRPLHLQLFPCLSPLLLDSRT---------LDPQ-------------GPTEAGWEVFDVWQVL 222

  Fly   207 R--YWLHNKGLQRRNELRISIGDSQLSTFAAGLVTPQASRTSLEPFIVGY---FNGPE---LLVK 263
            |  .|     .|...|||...|:.......|....||.| ..|:...:|:   ...|:   |||.
  Rat   223 RPQPW-----KQLCLELRAVWGELDARDSGARPRGPQQS-PPLDLRSLGFGRRVRPPQERALLVV 281

  Fly   264 IQKLRFKR----------DLEKRRAGGGSPPPPPPPPVDLYRPPQS------------------- 299
            ..:.:.|.          ..|...|.|..|.|...|....:.|...
  Rat   282 FTRSQRKNLFTEMHEQLGSAEAAGAEGSWPAPSGAPDAGSWLPSPGRRRRRTALSSRHGKRHGKK 346

  Fly   300 ----CERLNFTVDFKELHMHNWVIAPKKFEAYFCGGGCNFPLGTKMNATNHAIVQTLMHLKQP-H 359
                |.|....|:||||...:|:|||.::|||.|.|.|:|||.:.:..|||||:||||:...| .
  Rat   347 SRLRCSRKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDFPLRSHLEPTNHAIIQTLMNSMDPGS 411

  Fly   360 LPKPCCVPTVLGAITILRYLNEDIIDLTKYQKAVAKECGC 399
            .|..|||||.|..|:||.....:.:...:|:..|.:.|||
  Rat   412 TPPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVVESCGC 451

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
scw	NP_524863.3	TGFb_propeptide	39..254	CDD:480997	57/268 (21%)
		TGF_beta_BMP5_like	299..400	CDD:381639	45/125 (36%)
Gdf6	NP_001013056.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	29..93		14/63 (22%)
		TGFb_propeptide	66..282	CDD:480997	55/251 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	244..267		6/23 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	301..348		7/46 (15%)
		TGF_beta_GDF5_6_7	351..452	CDD:381644	45/101 (45%)